Background and Objectives: Different intravenous immunoglobulins (IVIGs) were found to be GB virus C/hepatitis G virus polymerase chain reaction (GBV–C/HGV–PCR)–positive. The potential transmission of this virus to recipients by a PCR–positive IVIG batch was investigated. Materials and Methods: Polyclonal IVIGs of different manufacturers and with different virus inactivation procedures were analyzed by GBV–C/HGV–PCR and anti–E2–ELISA. Follow–up sera of 13 participants of a clinical trial performed with a GBV–C/HGV–PCR–positive batch were retrospectively investigated for GBV–C/HGV seroconversion (specific antibodies, viral RNA). Results: Four out of ten IVIGs analysed by GBV–C/HGV–PCR were – at least for some batches – virus genome–positive. Virus inactivation by solvent/detergent treatment resulted in GBV–C/HGV–PCR–negative products. GBV–C/HGV–specific antibodies were detectable in all IVIGs analyzed. There was no transmission of GBV–C/HGV observed when recipients of a large amount of a GBV–C/HGV–PCR–positive batch were analyzed by an antibody test and specific PCR. Conclusions: Despite PCR positivity of an IVIG preparation no transmission of GBV–C/HGV to recipients was observed. Possible explanations are a sufficient virus inactivation procedure and/or presence of specific antibodies in the final products.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.