The human ABO blood group determinants are simple carbohydrate structures which are widely distributed in nature. Much work has been done on the structure of the A and B antigens but little is known on the regulation of anti-A and anti-B immune responses. To develop a model system, we have characterized the AB0 immunity of normal Balb/c mice and found a significant level of serum natural anti-A but almost no anti-B. This finding and the known IgM predominance among immune anti-A produced in the Balb/c mouse indicate that the ABO immunity of this mouse strain is comparable to the one of human blood group B individuals. Following immunization with human red blood cells, similar levels of anti-A were produced in normal and athymie Balb/c mice showing that the anti-A response is T cell independent. Furthermore, no anti-A or anti-B antibodies were produced in CBA/xid mice indicating a type 2 T-cell-independent immune response. These results may contribute to a better understanding of human AB0 responses and establish the mouse as a suitable model to study the immunobiology of AB0 antigens.

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1994
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