Abnormal amounts of platelet-associated immunoglobulins (PAIg) and seropositivity for HIV were demonstrated in 18 haemophiliacs suffering from thrombocytopenia of varying severity. Among 34 non-thrombocytopenic haemophiliacs seropositivity for HIV was found in association with increased levels of PAIg in 18 patients,whereas increased amounts of PAIg were seen only in 4 of the 16 patients seronegative for HIV. In most of the haemophiliacs with thrombocytopenia, the PAIg represented all classes of immunoglobulins and in half of the cases all subclasses of IgG, while in 33 patients with autoimmune thrombocytopenic purpura (AITP), PAIg was IgGl and IgM in most cases. Our data show a difference in the pattern of PAIg in AITP patients and in thrombocytopenic haemophiliacs seropositive for HIV. We suggest that the thrombocytopenia in haemophiliacs is related to the polyclonal B cell activation also found in other patients seropositive for HIV and perhaps indicative of AIDS-related complex.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.