Spleens from 14 healthy adult cats were isolated and perfused with cell-free Ringer’s solution. Histological studies on the splenic megakaryocytes, as well as a search for splenic megakaryocytes in samples of the splenic venous outflow, were performed. The samples of the splenic venous outflow contained a lower cellular concentration when perfusion was prolonged, but the number of megakaryocytes appearing in the venous samples increased. At least five different forms of megakaryocytes were observed from smears of the venous outflow:(i) unipolar, (ii) multipolar, (iii) foamy, (iv) mobile and (v) nuclear types. These types were also found in splenic venous outflow of dogs, kittens and bled cats. It is suggested that not only platelets but also the larger megakaryocytes can pass out of the splenic circulation. This may imply that megakaryocytes can be culled, matured in the splenic red pulp, and ultimately released into peripheral blood.

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