Hemolytic anemia is associated with Rhnun but not with Bombay blood. Preliminary evidence indicates that the Rh antigen which is lipoprotein in nature occupies sites on the red cell membrane surface. The absence of the lipoprotein which carries the Rh antigens in Rh(null) blood compromises the integrity of the membrane and the result is a mild hemolycic anemia. Recent findings indicate that the ABO glycoprotein molecule isolated from erythrocytic membranes is so oriented that its oligosaccharide-rich N-terminal end is exposed above the surface of the membrane and its C-terminal end remains in the interior of the membrane. The absence of ABO and H determinants in Bombay blood does not affect membrane integrity, so that Bombay blood is not associated with hemolytic anemia.

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