Using an automated differential agglutination procedure, 218 red cell survival studies were performed in patients requiring therapeutic transfusion. Blood was collected in acid-citrate-dextrose (ACD) or citrate-phosphate-dextrose (CPD). Some of the blood was stored as such and some as concentrated red cells. Adverse effects of storage on both washed and nonwashed whole blood and concentrated red cells were determined by 24-hour posttransfusion survival measurements. There were no significant differences in the storage limitations of non-washed ACD- and CPD-collected whole blood, and concentrated red cells. Washing stored red cells with either buffered or nonbuffered 0.9% sodium chloride solution with or without glucose did not significantly affect 24-hour survival. However,there was a significant decrease in survival when stored red cells were washed with CPD solution or with a buffered 0.9% sodium chloride solution supplemented with calcium and magnesium.

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