Laboratories carrying out routine grouping of donor bloods generally perform a screening test for donors whose serum contains high- titre anti-A and anti-B agglutinins. In view of the fact that in this country such donors are the source of practically all the ABO grouping serum in general use, it is a cause of surprise that very few figures appear to have been published previously regarding the percentage of donors in each group who posess an agglutinin titre sufficiently high to render their serum of value for diagnostic purposes. Only two reports appear to have been made so far - that of Rainsford and Morgan *, which reports on investigations on Royal Navy personnel, and that of Ramgren 5 who examined Swedish blood donors. The figures included in this survey are taken from high-titre screening tests performed at this laboratory during a period of twenty-two months during 1954 to 1956 on some 5000 donors.

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