The incidence of antinuclear antibodies was determined to be 39% in a group of 26 patients with Coombs positive acquired hemolytic anemia who lacked evidence of collagen disease or primary disturbances of the lymphoreticular system. There was no correlation between antinuclear antibodies and such factors as anemia, reticulocytosis, hypergammaglobulinemia and whether the Coombs reaction was related to pure IgG or to serum complement on the red cells. The significance of the antinuclear antibodies and their relationship to the acquired hemolytic process remain to be elucidated.

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