Weimann

No, but ERAS may be limited by comorbidity and impaired mobility – in any case, an individualized approach should be attempted.

Scheiermann

Severe neurologic impairment (hemiplegia, severe dementia, advanced M. Parkinson, …) does impose a burden which may exclude patients from participating in ERAS programs. However, this is a general remark and is not based on specific values or parameters. Thus, I propose an individual evaluation of any patients at risk.

Seyfried/Reissfelder

No. The components of the ERAS concept are defined in a standardized manner in the respective current guideline. There are patient-specific limitations that exclude patients from single or multiple items from the outset. For example, a patient who does not spend more than 4 h a day out of bed preoperatively is not expected to be able to do so postoperatively. Depending on the preoperative condition, it is possible that patients will not achieve the required 70% overall compliance. In terms of a database, such patients would be formally excluded from the program. Nevertheless, a large part of the program implementation is a culture change in daily clinical care. This means that even for patients outside the pathway, every single item is checked and fulfilled on a patient-specific basis so that such patients are formally treated outside the pathway but in practice receive the same care. Furthermore, these patients are an absolute minority. Even most of the older frail patients have been successfully treated within the pathways.

Weimann

Thoracic epidural analgesia (TEA) is the preferred mode in major open abdominal surgery, patient-controlled analgesia (PCA) in laparoscopic surgery. This is in line with the literature. Our experience is good.

Scheiermann

Given that there are no contraindications for TEA (anticoagulation, severe communication deficit, language barrier, …), TEA is preferred. The reason for that is the sympathicolysis without systemic opioid therapy. However, TEA must be removed quickly enough in order for patients to benefit from ERAS programs. Therefore, major liver surgery leading to impaired coagulation and consecutive contraindication for TEA removal (low prothrombin time, low platelets, …) in the days following surgery must be evaluated carefully. Prolonged TEA must be carefully balanced against rapid patient discharge to ambulatory care.

Seyfried/Reissfelder

In our clinic, we have very good experience using the transverse-abdominal plane block (TAP block). It can be applied safely, especially laparoscopically, but also in open surgery. The data in this respect are more than promising, and a publication is in preparation. It changed our standard procedure for postoperative pain management. Regarding the abovementioned procedures, we prefer intravenous PCA. The major problem with both procedures is the partial immobilization of patients, as wiring of any kind limits mobility. Randomized data related to TEA versus PCA in the context of an ERAS program showed a shorter hospitalization for patients with PCA.

Weimann

ESPEN guideline:

  • Weight loss >10–15% within 6 months

  • BMI <18.5 kg/m2

  • SGA C or NRS >5

  • Preoperative serum albumin <30 g/L (with no evidence of hepatic or renal dysfunction).

Scheiermann

In our department, during the routine preoperative assessment, we use a frailty check consisting of several screening items (i.e., recent weight loss, physical activity [MET] assessment, physical strength assessment, walking speed, and the MiniCog-Test).

Seyfried/Reissfelder

It has been shown several times that a trimodal prehabilitation can achieve the best effects. The pillars mentioned here are psychological support, nutritive support, and physical activity. These three cornerstones for risk constellations must be detected. There are validated scores for all areas which represent problems with a good sensitivity. In our own procedure, we use

Nutritive

Nutrition Risk Score (NRS), if necessary, bio-impedance analysis.

Cognitive

Psycho-oncological interview in case of abnormalities Center for Epidemiologic Studies-Depression (CES-D) scale, if necessary, also full geriatric assessment.

Activity

Conversation about general everyday coping and if necessary, Short Questionnaire to Assess Health-enhancing Physical Activity (SQUASH).

Weimann

Shared decision-making regarding risk stratification and potential benefit of prehabilitation. Individualized including oral nutritional supplements and physiotherapy for 4–6 weeks, at least once psychological support.

Scheiermann

After identifying patients at risk, measures must be taken in order to reduce postoperative complications for the respective patients. Preventing weight loss, increasing muscle strength, and respiratory training aiming at improving pulmonary function are some of the measures which should be taken in order to optimize patients’ outcome.

Seyfried/Reissfelder

Unlike ERAS concepts, a prehabilitation program must be tailored to the individual patient and can range from a full geriatric assessment with preoperative inpatient stay to outpatient nutritional counseling. The vast majority of these patients are treated within the framework of study protocols and real-world data from clinical practice (which must then also reflect economic aspects) remain to be seen. The early identification of high-risk patients with suitable scores, including cognitive function if necessary, is essential. In our own procedure, cognitive function may also be assessed. Some groups perform spiroergometry as a standard procedure, but many high-risk patients cannot be expected to undergo this. Looking at the current literature, only frail patients seem to benefit from prehabilitation in terms of a better postoperative outcome.

Weimann

According to the ESPEN guideline, preoperative PN shall be administered only in patients with malnutrition or severe nutritional risk, where energy requirement cannot be adequately met by enteral nutrition (A). A time period of 7–14 days is recommended (0).

Scheiermann

Since anesthetists mostly see the respective patients on the preoperative day in order to evaluate the patient and obtain informed consent, I am not involved in preoperative parenteral nutrition, and therefore, I do not have a clear cutoff value for preoperative parenteral nutrition. However, low BMI, low serum protein/albumin, low muscle strength/wasting, or inability to ingest enteral nutrition are strongly suggestive for implementing preoperative parenteral nutrition.

Seyfried/Reissfelder

As in many aspects, the nutritive status should be as good as possible, and a widely established value is the serum albumin level (>30 mg/dL). The serum albumin level is a clear risk factor for postoperative morbidity, especially for anastomotic leakage. So, if possible, patients with a lower albumin level should receive protein drinks and parenteral nutrition. However, as in many clinical applications, patient-specific target values should be established. Related to what can the patient achieve and what would be specifically desirable for the individual procedure and the underlying disease.

Weimann

Awareness for the increased risk, risk assessment including functional scores (Fried frailty, 6MWD), and even cognitive function (Mini Mental Status Test).

Scheiermann

Anesthesia must be adapted to the frail population treated in the university hospital setting. Focus must be on the patient’s recovery following surgery. Especially pulmonary complications must be avoided. Therefore, respiratory therapy in combination with potent analgesia are valuable measures in this respect.

Seyfried/Reissfelder

Based on our standards, we do not differentiate between patient groups in the baseline assessment. If there are abnormalities in the basic assessment, additional tools are added according to the modular principle. Nevertheless, we implemented a delirium prophylaxes pathway, as this is a main problem in frail patients.

Weimann

No delay for cancer surgery. No change in postoperative interventional management. The nursing staff shortage with turnover leads to a prioritization of duties and is a considerable burden for ERAS including nutritional care.

Scheiermann

During the COVID-19 pandemic, ICU beds for non-COVID-19 patients were short. However, the main reason for this dramatic shortage in ICU capacity is the shortage in nursing staff. Therefore, focus must be placed on avoiding fluctuation in nursing staff, holding nurses in their job, and by making this important job by all means attractive. Although the pandemic does not affect the intensive care units at the moment, the shortage in ICU beds persists. Therefore, I give my very best to enable major visceral surgery even without postoperative ICU capacity (prolonged PACU stay, postoperative intermediate care unit rather than ICU, …).

Seyfried/Reissfelder

In addition to the positive patient-related aspects of an ERAS program, a major aspect that is important in the current situation is the relief for hospital staff. In the ERAS concept, enlightened and empowered patients become active members of their own treatment through diaries, checklists, and predefined pathways. In addition to the effects of the shorter length of stay, which automatically reduces the hours of care, informed patients are also significantly more independent. Almost all items of the pathway also lead to a reduction in nursing work (drains that are not placed do not have to be taken care, patients who are out of bed can also weigh themselves, etc.). The last point is that the nursing staff started to identify themselves with their daily work again.

Florian Kühn: no conflicts of interest to declare. Christian Schulz: no conflicts of interest to declare. Arved Weimann: lecture fees: Baxter, B. Braun/Melsungen, Fresenius Kabi, Falk Foundation; research grant: B. Braun, Mucos Patrick Scheiermann: no conflicts of interest to declare. Steffen Seyfried: no conflicts of interest to declare. Christoph Reissfelder: no conflicts of interest to declare.

Dr. Florian Kühn

Department of General, Visceral and Transplant Surgery

University Hospital of LMU Munich

Marchioninistr 15

81377 Munich, Germany

Florian.Kuehn@med.uni-muenchen.de

Prof. Christian Schulz

Medical Department II

University Hospital, LMU Munich

Marchioninistrasse 15

81377 Munich, Germany

Chr.Schulz@med.uni-muenchen.de

Prof. Dr. Arved Weimann

Abteilung für Allgemein-, Viszeral- und Onkologische Chirurgie

Klinikum St. Georg, Leipzig

Delitzscher Str. 141

04129 Leipzig, Germany

Arved.Weimann@sanktgeorg.de

Dr. Patrick Scheiermann

Department of Anesthesiology

LMU University Hospital – Campus Großhadern

Marchioninistr. 15

81377 Munich, Germany

Patrick.Scheiermann@med.uni-muenchen.de

Dr. Steffen Seyfried

Department of Surgery, Universitätsmedizin Mannheim

Medical Faculty Mannheim, Heidelberg University

Theodor-Kutzer-Ufer 1-3

68167 Mannheim, Germany

steffen.seyfried@umm.de

Prof. Christoph Reissfelder

Department of Surgery

Universitätsmedizin Mannheim, Medical Faculty Mannheim

Heidelberg University

Theodor-Kutzer-Ufer 1-3

68259 Mannheim, Germany

christoph.reissfelder@umm.de

Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.