Eine Vielzahl von diagnostischen Methoden steht zur exakten Evaluierung der gastroösophagealen Refluxkrankheit (GERD) zur Verfügung. Während die Manometrie in der Diagnostik nur einen begrenzten Stellenwert hat, ist die pH-Metrie, transnasal oder auch kabellos, weiterhin ein wichtiger Baustein in der Diagnostik der therapierefraktären GERD. Seit der Einführung der kombinierten pH-Metrie und Impedanzmessung hat sich das pathophysiologische Verständnis von saurem und nicht saurem Reflux vertieft. Unabhängig vom Säuregehalt ist dies für die Identifikation von Refluxereignissen von Bedeutung, um die Korrelationen mit Symptomen einzustufen.

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