FISH-positive result of a voided urine specimen: 3 tumor cell nuclei showing increased copy number (polysomy) of the chromosomes 3 (aqua, 4 signals), 7 (spectrum-red, 4–5 signals), but a normal copy number of chromosome 17 (spectrum-green, 2 signals). There is a loss (deletion) of 9p21 (spectrum-gold, 0–1 signals). ×1,000.