Spectrum of MRI findings in patients with HbSC disease. MRI, magnetic resonance imaging; HbSC, hemoglobin SC; FLAIR, fluid-attenuated inversion recovery. a Axial T2-weighted image shows punctate hyperintense foci within the left caudate head and right medial thalamus, compatible with chronic lacunar infarcts. b Axial T2-weighted shows encephalomalacia and hemosiderin staining within the left periventricular white matter. c Axial T2-weighted image shows global cerebral volume loss with mild ventriculomegaly. d Axial FLAIR image shows scattered punctate hyperintense foci within the white matter of the bilateral cerebral hemispheres, most compatible with chronic microvascular changes. e Axial susceptibility-weighted image shows multiple scattered foci of magnetic susceptibility within the subcortical white matter of the bilateral cerebral hemispheres consistent with chronic microhemorrhages.