Hintergrund: Personen mit Schmerzsymptomen leiden häufig unter komorbider Depression. Die Gate-Control-Theorie nimmt an, dass die Schmerzwahrnehmung durch psychosoziale Einflüsse moduliert wird und dass die Linderung von Depressionen entsprechend auch Schmerzen verringern kann. Da Schmerzpatienten oft immobil sind und die psychotherapeutische Versorgung unzureichend ist, stellen Online-Interventionen eine vielversprechende Alternativbehandlung dar. Die vorliegende randomisiert-kontrollierte Studie untersucht die Wirksamkeit der Online-Intervention novego – Depressionen bewältigen bei Schmerzpatienten mit depressiven Symptomen. Patienten und Methoden: Von den re-krutierten Teilnehmern mit Schmerzen und depressiven Symptomen wurden je 71 Personen randomisiert der Interventionsgruppe oder der Wartekontrollgruppe zugeteilt. Der Interventionszeitraum betrug 12 Wochen. Zum Baseline- und Postzeitpunkt wurden depressive (BDI-II; primärer Endpunktparameter) sowie Schmerzsymptome (VAS, DSF; sekundäre Endpunktparameter) erfasst. Ergebnisse: Die Teilnehmer der novego-Gruppe zeigten einen signifikanten Rückgang im BDI-II mit einer kleinen bis mittleren Effektgröße von ηp2 = 0,043 in der Intention-to-treat-Analyse und ηp2 = 0,057 in der Per-protocol-Analyse. Die Schmerzsymptome gingen in beiden Gruppen gleichermaßen ohne signifikante Unterschiede zurück. Explorative Moderationsanalysen zeigten jedoch, dass Patienten mit Schmerzen in den Händen oder im oberen Rücken signifikant von novego bezüglich der Schmerzsymptomatik profitierten. Die Zufriedenheit mit der Intervention war hoch. Schlussfolgerung: Die Online-Intervention novego ist geeignet, um depressive Symptome bei Teilnehmern mit unterschiedlicher Schmerz-symptomatik zu reduzieren. Patienten mit Schmerzen in den Händen oder im oberen Rücken können besonders davon profitieren.

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