Obwohl Zwangsstörungen im Kindes- und Jugendalter mittlerweile als gut behandelbar gelten, sind die Behandlungsergebnisse in der Praxis häufig unbefriedigend. Dies liegt daran, dass nachweislich wirksame Interventionen nicht oder unzureichend angewendet werden. Die vorliegende Arbeit gibt eine Übersicht über evidenzbasierte psychotherapeutische und medikamentöse Behandlungsmöglichkeiten. Die Behandlung der Wahl ist die Kognitive Verhaltenstherapie mit Exposition und Reaktionsverhinderung, die, falls erforderlich, um eine Pharmakotherapie mit einem selektiven Serotonin-Wiederaufnahme-Hemmer ergänzt wird. Befunde zu Prädiktoren, Moderatoren und Mediatoren der Behandlung sind uneinheitlich. Neue Entwicklungen in der Psychotherapie beinhalten Anwendungen der Expositionsbehandlung, die nicht einem Habituationsrational folgen, sondern auf Angsthemmung und Angsttoleranz sowie auf kognitive (Erwartungsverletzung) oder metakognitive Veränderungen abzielen. Bei Kindern mit geringer Behandlungsmotivation und starker Einbindung der Familie in die Zwänge des Kindes sind elternbezogene Interventionen indiziert. Behandlungsfehler in der Expositionsbehandlung sollten in der Ausbildung von Kinder- und Jugendlichenpsychotherapeuten besonders berücksichtigt werden.

1.
Arch JJ, Abramowitz JS: Exposure therapy for obsessive-compulsive disorder: an optimizing inhibitory learning approach. J Obsessive Compuls Relat Disord 2015;6:174-182.
2.
Bloch MH, Storch EA: Assessment and management of treatment-refractory obsessive-compulsive disorder in children. J Am Acad Child Adolesc Psychiatry 2015;54:251-262.
3.
Böge I, Mayer L, Corpus N, et al: Home treatment - insbesondere für expansive Jungen? Alters- und geschlechtsspezifische Wirksamkeit von Home treatment bei internalisierenden vs. externalisierenden Störungen. Z Kinder Jugendpsychiatr Psychother 2015;43:161-171.
4.
Bolton D, Perrin S: Evaluation of exposure with response-prevention for obsessive compulsive disorder in childhood and adolescence. J Behav Ther Exp Psychiatry 2008;39:11-22.
5.
Bolton D, Williams T, Perrin S, et al: Randomized controlled trial of full and brief cognitive behaviour therapy and waitlist for paediatric obsessive-compulsive disorder. J Child Psychol Psychiatry 2011;52:1269-1278.
6.
Calvocoressi L, Mazure CM, Kasl SV, et al: Family accomodation of obsessive-compulsive symptoms. Instrument development and assessment of family behavior. J Nerv Ment Dis 1999;187:636-642.
7.
Chu BC, Colognori DB, Yang G, et al: Mediators of exposure therapy for youth obsessive-compulsive disorder: specificity and temporal sequence of client and treatment factors. Behav Ther 2015;46:395-408.
8.
Craske MG: Optimizing exposure therapy for anxiety disorders: an inhibitory learning and inhibitory regulation approach. Verhaltenstherapie 2015;25:134-143.
9.
Craske MG, Kircanski K, Zelikowsky M, et al: Optimizing inhibitory learning during exposure therapy. Behav Res Ther 2008;46:5-27.
10.
Craske MG, Treanor M, Conway CC, et al: Maximizing exposure therapy: an inhibitory learning approach. Behav Res Ther 2014;58:10-23.
11.
de Haan E, Hoogduin KA, Buitelaar JK, et al: Behavior therapy versus clomipramine for the treatment of obsessive-compulsive disorder in children and adolescents. J Am Acad Child Adolesc Psychiatry 1998;37:1022-1029.
12.
Ecker W, Kupfer J, Gönner S: Selbstbezogenes Unvollständigkeitserleben bei Zwangsstörungen. Verhaltenstherapie 2013;23:12-21.
13.
Franklin ME, Kratz HE, Freeman JB, et al: Cognitive-behavioral therapy for pediatric obsessive-compulsive disorder: empirical review and clinical recommendations. Psychiatry Res 2015;227:78-92.
14.
Freeman J, Sapyta J, Garcia A, et al: Family-based treatment of early childhood obsessive-compulsive disorder: the Pediatric Obsessive-Compulsive Disorder Treatment Study for Young Children (POTS Jr) - a randomized clinical trial. JAMA Psychiatry 2014;71:689-698.
15.
Garcia AM, Sapyta JJ, Moore PS, et al: Predictors and moderators of treatment outcome in the Pediatric Obsessive Compulsive Treatment Study (POTS I). J Am Acad Child Adolesc Psychiatry 2010;49:1024-1033.
16.
Geller DA, Wagner KD, Emslie G, et al: Paroxetine treatment in children and adolescents with obsessive-compulsive disorder: a randomized, multicenter, double-blind, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry 2004;43:1387-1396.
17.
Gillihan SJ, Williams MT, Malcoun E, et al: Common pitfalls in exposure and response prevention (EX/RP) for OCD. J Obsessive Compuls Relat Disord 2012;1:251-257.
18.
Ginsburg GS, Kingery JN, Drake KL, et al: Predictors of treatment response in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 2008;47:868-878.
19.
Gøtzsche PC: Author's reply to Dubicka and colleagues and Stone. BMJ 2016;352:i915.
20.
Ivarsson T, Skarphedinsson G, Kornør H, et al: The place of and evidence for serotonin reuptake inhibitors (SRIs) for obsessive compulsive disorder (OCD) in children and adolescents: views based on a systematic review and meta-analysis. Psychiatry Res 2105;227:93-103.
21.
Keeley ML, Storch EA, Merlo LJ, Geffken GR: Clinical predictors of response to cognitive-behavioral therapy for obsessive-compulsive disorder. Clin Psychol Rev 2008;28:118-130.
22.
Kircanski K, Lieberman MD, Craske MG: Feelings into words: contributions of language to exposure therapy. Psychol Sci 2012;23:1086-1091.
23.
Kircanski K, Peris TS: Exposure and response prevention process predicts treatment outcome in youth with OCD. J Abnorm Child Psychol 2015;43:543-552.
24.
Krebs G, Heyman I: Obsessive-compulsive disorder in children and adolescents. Arch Dis Child 2015;100:495-499.
25.
Krebs G, Isomura K, Lang K, et al: How resistant is «treatment-resistant» obsessive-compulsive disorder in youth? Brit J Clin Psychol 2015;54:63-75.
26.
Lebowitz ER: Treatment of extreme family accommodation in a youth with obsessive-compulsive disorder; in Storch EA, Lewin AB (eds): Clinical Handbook of Obsessive-Compulsive and Related Disorders. Heidelberg, Springer, 2016, pp 321-336.
27.
Lebowitz ER, Omer H: Treating Childhood and Adolescent Anxiety: a Guide for Caregivers. New Jersey, Wiley, 2013.
28.
Lewin AB, Park JM, Jones AM, et al: Family-based exposure and response prevention therapy for preschool-aged children with obsessive-compulsive disorder: a pilot randomized controlled trial. Behav Res Ther 2014;56:30-38.
29.
Lewin AB, Peris TS, Bergman RL, et al: The role of treatment expectancy in youth receiving exposure-based CBT for obsessive compulsive disorder. Behav Res Ther 2011;49:536-543.
30.
Liebowitz MR, Turner SM, Piacentini J, et al: Fluoxetine in children and adolescents with OCD: a placebo-controlled trial. J Am Acad Child Adolesc Psychiatry 2002;41:1431-1438.
31.
Masi G, Pfanner C, Brovedani P: Antipsychotic augmentation of selective serotonin reuptake inhibitors in resistant tic-related obsessive-compulsive disorder in children and adolescents: a naturalistic comparative study. J Psychiatr Res 2013;47:1007-1012.
32.
McGuire JF, Piacentini J, Lewin AB, et al: A meta-analysis of cognitive behavior therapy and medication for child obsessive-compulsive disorder: moderators of treatment efficacy, response, and remission. Depress Anxiety 2015;32:580-593.
33.
Omer H, Lebowitz E: Ängstliche Kinder unterstützen: Die elterliche Ankerfunktion. Göttingen, Vandenhoeck & Ruprecht, 2015.
34.
Pediatric OCD Treatment Study (POTS) Team: Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial. JAMA 2004;292:1969-1976.
35.
Peris TS, Sugar CA, Bergman RL, et al: Family factors predict treatment outcome for pediatric obsessive-compulsive disorder. J Consult Clin Psychol 2012;80:255-263.
36.
Piacentini J, Bergman RL, Chang S, et al: Controlled comparison of family cognitive behavioral therapy and psychoeducation/relaxation training for child obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 2011;50:1149-1161.
37.
Poustka L, Rothermel B: Zwangsstörungen, in Lehmkuhl G, Poustka F, Holtmann M, Steiner H (eds): Praxishandbuch Kinder- und Jugendpsychiatrie. Göttingen, Hogrefe, 2015, pp 360-372.
38.
Reynolds SA, Clark S, Smith H, et al: Randomized controlled trial of parent-enhanced CBT compared with individual CBT for obsessive-compulsive disorder in young people. J Consult Clin Psychol 2013;81:1021-1026.
39.
Riddle MA, Reeve EA, Yaryura-Tobias JA, et al: Fluvoxamine for children and adolescents with obsessive-compulsive disorder: a randomized, controlled, multicenter trial. J Am Acad Child Adolesc Psychiatry 2001;40:222-229.
40.
Rudy BM, Lewin AB, Geffken GR, et al: Predictors of treatment response to intensive cognitive-behavioral therapy for pediatric obsessive-compulsive disorder. Psychiatry Res 2014;220:433-440.
41.
Scahill L, Riddle MA, McSwiggin-Hardin M, et al: Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 1997;36:844-852.
42.
Simons M, Schneider S, Herpertz-Dahlmann B: Metacognitive therapy versus exposure and response prevention for pediatric obsessive-compulsive disorder. A case series with randomized allocation. Psychother Psychosom 2006;75:257-264.
43.
Simons M: Zwangsstörungen im Kindes- und Jugendalter; in Meinlschmidt G, Schneider S, Margraf J (eds): Lehrbuch der Verhaltenstherapie. Materialien für die Psychotherapie, Bd. 4. Berlin, Springer, 2012a.
44.
Simons M: Anders denken - Metakognitive Therapie für Kinder und Jugendliche mit Zwangsstörung: Ein Behandlungsplan. Verhaltenstherapie 2012b;22:259-267.
45.
Simpson HB, Foa EB, Liebowitz MR, et al: Cognitive-behavioral therapy vs risperidone for augmenting serotonin reuptake inhibitors in obsessive-compulsive disorder: a randomized clinical trial. JAMA Psychiatry 2013;70:1190-1199.
46.
Solem S, Håland AT, Vogel PA, et al: Change in metacognitions predicts outcome in obsessive-compulsive disorder patients undergoing treatment with exposure and response prevention. Behav Res Ther 2009;47:301-307.
47.
Steinhausen H-C: CYBOCS. Beurteilungsskala für Zwangsstörungen bei Kindern. Autorisierte deutsche Bearbeitung der dritten Revision (1993). 2007.
48.
Storch EA, Bussing R, Small BJ, et al: Randomized, placebo-controlled trial of cognitive-behavioral therapy alone or combined with sertraline in the treatment of pediatric obsessive-compulsive disorder. Behav Res Ther 2013;51:823-829.
49.
Torp NC, Dahl K, Skarphedinsson G, et al: Predictors associated with improved cognitive-behavioral therapy outcome in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 2015;54:200-207.
50.
Valderhaug, R, Gunnar Gotestam K, Larsson B: Clinicians' views on management of obsessive-compulsive disorders in children and adolescents. Nordic J Psychiatry 2004;58:125-132.
51.
Vloet TD, Herpertz-Dahlmann B, Simons M: Neue Entwicklungen bei der psychotherapeutischen und pharmakologischen Behandlung der Zwangsstörung im Kindes- und Jugendalter. Z Kinder Jugendpsychiatr Psychother 2017;45:9-22.
52.
Wells A: Metakognitive Therapie bei Angststörungen und Depression. Weinheim, Beltz, 2011.
53.
Wewetzer C, Wewetzer G: Therapie der Zwangsstörung im Kindes- und Jugendalter. Kindh Entwickl 2014;23:102-111.
54.
Williams TI, Salkovskis PM, Forrester L, et al: A randomised controlled trial of cognitive behavioural treatment for obsessive compulsive disorder in children and adolescents. Eur Child Adolesc Psychiatry 2010;19:449-456.
55.
Wu MS, McGuire JF, Martino C, et al: A meta-analysis of family accommodation and OCD symptom severity. Clin Psychol Rev 2016;45:34-44.
56.
Zbozinek TD, Holmes EA, Craske MG: The effect of positive mood induction on reducing reinstatement fear: relevance for long term outcomes of exposure therapy. Behav Res Ther 2015;71:65-75.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.