...Marco Oderda; Fulvio Ricceri; Francesca Pisano; Chiara Fiorito; Alberto Gurioli; Giovanni Casetta; Andrea Zitella; Donatella Pacchioni; Paolo Gontero Objectives: To prospectively evaluate the prognostic utility of the traditional prognostic factors and molecular markers p53 and Ki-67...

...Bin Xu; Yuan-Yuan Mi; Zhi-Chao Min; Gong Cheng; Na Tong; Jun Tao; Peng-Chao Li; Mei-Lin Wang; Jia-Lin Tang; Zheng-Dong Zhang; Ning-Hong Song; Wei Zhang; Hong-Fei Wu; Ning-Han Feng; Li-Xin Hua Introduction: Alterations in P53 and Murine Double Minute 2 ( MDM2 ) genes appear to be important...

... was induced by partial ligation of the left renal vein and animals were sacrificed at 1, 3, and 4 weeks after varicocele creation. The levels of activated p53 and γ-H2AX formation were determined by Western blot analysis and immunohistochemistry. Results: γ-H2AX formation was augmented after varicocele...

...Önder Yaman; Erol Özdiler; Diclehan Orhan; Serpil Dizbay Sak; Sümer Baltacı; Özden Tulunay; Orhan Göǧ;üş A role of genetic alterations in the p53 tumor suppressor gene has been implicated in many types of human malignancies. In this study, we examined the prevalence of immunohistochemically...

... following enzymatic dissocation, characterised by immunohistochemistry and electron microscopy, and further studied for abnormal p53 or retinoblastoma genes. Cells in culture were shown to maintain the morphological attributes of the primary lesion, including the overproduction of mitochondria. Despite...

...LuCheng Liu; DeChun Zhu; RuiJuan Gao; Hang Guo Aim: To evaluate the expression profile of vascular endothelial growth factor (VEGF), kinase-insert-domain-containing receptor (KDR) and p53 in patients from Northeastern China with transitional cell carcinoma (TCC) of bladder. Materials and Methods...

...’ prognosis was examined in 142 urothelial cell carcinomas. The expression of these proteins was also analyzed along with other cell-cycle-related proteins such as: p53, pRb and the proliferation-associated indices Ki-67 and proliferating cell nuclear antigen (PCNA). Patients and Methods: These molecule...

... the genotypic and phenotypic patterns of p53 in patients with transitional cell carcinoma (TCC) of the urinary bladder. Materials and Methods: Cross-sectional study of 73 patients diagnosed with TCC. DNA was obtained from the tumor tissue to perform polymerase chain reaction-single strand conformational...

...Han Ruifa; Liu Liwei; Lu Binxin; Li Ximing Objective: Gene therapy is defined as the treatment of an acquired or inherited disease by transfer of genetic material. The most common strategies in gene therapy of bladder cancer are corrective, inductive and cytotoxic gene therapy. Mutations in the p53...

...Eyup Gumus; Sibel Erdamar; Gulderen Demirel; Kaya Horasanli; Gökhan Özmen; Cengiz Miroglu Introduction: Etiology of serum anti-p53 antibodies in bladder cancer patients is still unknown. In this study we evaluated the relationship between serum anti-p53 antibodies and microvessel density in bladder...

...Eyup Gumus; Gulderen Demirel; Orhan Tanriverdi; Kaya Horasanli; Gökhan Özmen; Cengiz Miroglu Introduction: To investigate the prognostic importance of the changes in serum p53 antibody titrations during follow-up of patients who had anti-p53 antibody-positive invasive bladder tumors...

...Yuh-Shyan Tsai; Tzong-Shin Tzai; Nan-Hua Chow; Wen-Horng Yang; Yat-Ching Tong; Johnny S.N. Lin; Chien-Chen Chang; Hong-Lin Cheng; Yung-Ming Lin Objectives: To explore the clinical significance of p53 and HER-2/neu coexpression by immunohistochemistry in patients with invasive bladder cancer...

...Ashok K. Hemal; Anurag Khaitan; Amit K. Dinda; Narmada P. Gupta; Amlesh Seth; P.N. Dogra; Gulam Nabi Introduction: The objective of the study was to determine the pattern of p53 expression in patients with muscle invasive bladder cancer treated with cystectomy and to assess the prognostic value...

...Feliksas Jankevicius; Peter Goebell; Mayumi Kushima; Wolfgang A. Schulz; Rolf Ackermann; Bernd J. Schmitz-Dräger Introduction: Induction of apoptosis and regulation of cell cycle checkpoints are important mechanisms of chemotherapy-induced cell death. The intact p53 tumor suppressor gene...

...Kazumi Suzuki; Akihiko Tokue Objectives: This study was designed to examine the expressions of bcl-2, p53 and Ki-67 antigen in collecting duct carcinoma (CDC) of the kidney by an immunohistochemical method. Methods: The diagnosis of CDC was based on the criteria proposed by Srigley and Eble...

...Ramazan Asci; Levent Yildiz; Saban Sarikaya; Recep Buyukalpelli; Ali Faik Yilmaz; Bedri Kandemir Objectives: Transitional cell carcinoma (TCC) of the bladder in younger patients has historically a favourable prognosis. bcl-2 and p53 genes are implicated in cell cycle regulation with roles...

...Taizo Shiraishi; Masatoshi Watanabe; Tsuyoshi Muneyuki; Tsuyoshi Nakayama; Jyouji Morita; Haruo Ito; Toshihiko Kotake; Ryuichi Yatani A series of 66 prostate cancer samples were studied immunohistochemically for expression of p53, p21, a cyclin-dependent kinase inhibitor regulated by p53...