Clear cell adenocarcinoma of the female urethra is a rare tumour of unknown origin. Here, we report 4 patients with such malignancy and argue for proper identification of the disease entity and radical surgery based on the available literature.

Keywords:
Clear cell adenocarcinoma, Female, Urethra
1.
Derksen JW, Visser O, de la Rivière GB, Meuleman EJ, Heldeweg EA, Lagerveld BW: Primary urethral carcinoma in females: an epidemiologic study on demographical factors, histological types, tumour stage and survival. World J Urol 2013;31:147-153.
2.
Rabbani F: Prognostic factors in male urethral cancer. Cancer 2011;117:2426-2434.
3.
Alexiev BA, Tavora F: Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems. Virchows Arch 2013;462:193-201.
4.
Eble JN, Sauter G, Epstein JI, Sesterhann IA: Pathology and Genetics of Tumours of the Urinary Systen and Male Genital Organs, Lyon, IARC Press, 2004.
5.
Mehra R, Vats P, Kalyana-Sundaram S, Udager AM, Roh M, Alva A, Pan J, Lonigro RJ, Siddiqui J, Weizer A, Lee C, Cao X, Wu YM, Robinson DR, Dhanasekaran SM, Chinnaiyan AM: Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. Am J Pathol 2014;184:584-591.
6.
Gakis G, Witjes JA, Compérat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM; European Association of Urology: EAU guidelines on primary urethral carcinoma. Eur Urol 2013;64:823-830.
7.
Dalbagni G, Zhang ZF, Lacombe L, Herr HW: Female urethral carcinoma: an analysis of treatment outcome and a plea for a standardized management strategy. Br J Urol 1998;82:835-841.
8.
Dimarco DS, Dimarco CS, Zincke H, Webb MJ, Bass SE, Slezak JM, Lightner DJ: Surgical treatment for local control of female urethral carcinoma. Urol Oncol 2004;22:404-409.
9.
Amin MB, Young RH: Primary carcinomas of the urethra. Semin Diagn Pathol 1997;14:147-160.
10.
Dayyani F, Pettaway CA, Kamat AM, Munsell MF, Sircar K, Pagliaro LC: Retrospective analysis of survival outcomes and the role of cisplatin-based chemotherapy in patients with urethral carcinomas referred to medical oncologists. Urol Oncol 2013;31:1171-1177.
11.
Oliva E, Young RH: Clear cell adenocarcinoma of the urethra: a clinicopathologic analysis of 19 cases. Mod Pathol 1996;9:513-520.
12.
Drew PA, Murphy WM, Civantos F, Speights VO: The histogenesis of clear cell adenocarcinoma of the lower urinary tract. Case series and review of the literature. Hum Pathol 1996;27:248-252.
13.
Rivard DJ, Waisman SS: Primary mesonephric carcinoma of the female urethra. J Urol 1985;134:756-757.
14.
Spencer JR, Brodin AG, Ignatoff JM: Clear cell adenocarcinoma of the urethra: evidence for origin within paraurethral ducts. J Urol 1990;143:122-125.
15.
Tong GX, Weeden EM, Hamele-Bena D, Huan Y, Unger P, Memeo L, O'Toole K: Expression of PAX8 in nephrogenic adenoma and clear cell adenocarcinoma of the lower urinary tract: evidence of related histogenesis? Am J Surg Pathol 2008;32:1380-1387.
16.
Sung MT, Zhang S, MacLennan GT, Lopez-Beltran A, Montironi R, Wang M, et al: Histogenesis of clear cell adenocarcinoma in the urinary tract: evidence of urothelial origin. Clin Cancer Res 2008;14:1947-1955.
17.
Hartmann A, Junker K, Dietmaier W, Schröder S, Lopez D, Hofstädter F, Blaszyk H: Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma. Hum Pathol 2006;37:117-120.
18.
Brimo F, Herawi M, Sharma R, Netto GJ, Epstein JI, Illei PB: Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis. Hum Pathol 2011;42:1613-1619.
19.
Alexiev BA, Tavora F: Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems. Virchows Arch 2013;462:193-201.
20.
Scantling D, Ross C, Jaffe J: Primary clear cell adenocarcinoma of a urethral diverticulum treated with multidisciplinary robotic anterior pelvic exenteration. Case Rep Med 2013;2013:387591.
21.
Reis LO, Billis A, Ferreira FT, Ikari LY, Stellini RF, Ferreira U: Female urethral carcinoma: evidences to origin from Skene's glands. Urol Oncol 2011;29:218-223.
22.
Miller J, Karnes RJ: Primary clear-cell adenocarcinoma of the proximal female urethra: case report and review of the literature. Clin Genitourin Cancer 2008;6:131-133.
23.
Doddamani D, Ansari MS, Gupta NP, Aron M, Singh I, Datta Gupta S: Mesonephroid adenocarcinoma of the bladder and urethra: a case report. Int Urogynecol J Pelvic Floor Dysfunct 2002;13:47-49.
24.
Dimarco DS, Dimarco CS, Zincke H, Webb MJ, Bass SE, Slezak JM, Lightner DJ: Surgical treatment for local control of female urethral carcinoma. Urol Oncol 2004;22:404-409.
25.
Patanaphan V, Prempree T, Sewchand W, Hafiz MA, Jaiwatana J: Adenocarcinoma arising in female urethral diverticulum. Urology 1983;22:259-264.
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2016
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