Endodermal sinus (yolk sac) tumors (ESTs) are rare neoplasms that most commonly arise in the ovaries or testis. Only six cases of prostatic ESTs have been reported in the literature. We report a case of prostatic EST, the first case in which the patient had a history of previous testis cancer. Treatment included cisplatin-based chemotherapy and radical prostatectomy. Previous cases of primary ESTs and use of cisplatin-based therapy as well as metastatic tumors to the prostate are discussed.

Benson RC Jr, Segura JW, Carney JA: Primary yolk-sac (endodermal sinus) tumor of the prostate. Cancer 1978;41:1395-1398.
Dalla Palma P, Dante S, Guazzieri S, Sperandio P: Primary endodermal sinus tumor of the prostate: report of a case. Prostate 1988;12:255-261.
Schriber J, Flax S, Trudeau M, Cook GT, Weizel H, Katz A, Keating A: Primary yolk sac (endodermal sinus) tumor of the prostate: case report and review of the literature. Prostate 1990;17:137-143.
Tay HP, Bidair M, Shabaik A, Gilbaugh JH 3rd, Schmidt JD: Primary yolk sac tumor of the prostate in a patient with Klinefelter's syndrome. J Urol 1995;153:1066-1069.
Namiki K, Tsuchiya A, Noda K, Oyama H, Ishibashi K, Kusama H, Furusato M: Extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome. Int J Urol 1999;6:158-161.
Sato S, Shinohara N, Harabayashi T, Nonomura K, Koyanagi T: Testicular nonseminomatous germ cell cancer presenting with metastasis to prostate and seminal vesicles. BJU Int 2002;90(4cr):472.
Michel F, Gattegno B, Roland J, Coloby P, Colbert N, Thibault P: Primary nonseminomatous germ cell tumor of the prostate. J Urol 1986;135:597-599.
Khandekar JD, Holland JM, Rochester D, Christ ML: Extragonadal seminoma involving urinary bladder and arising in the prostate. Cancer 1993;71:3972-3974.
Hayman R, Patel A, Fisher C, Hendry WF: Primary seminoma of the prostate. Br J Urol 1995;76:273-274.
Sell S, Pierce GB: Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers. Lab Invest 1994;70:6-22.
Mitchell PL, Al-Nasiri N, A'Hern R, Fisher C, Horwich A, Pinkerton CR, Shepherd JH, Gallagher C, Slevin M, Harper P, Osborne R, Mansi J, Oliver T, Gore ME: Treatment of nondysgerminomatous ovarian germ cell tumors: an analysis of 69 cases. Cancer 1999;85:2232-2244.
Han G, Miura K, Takayama T, Tsutsui Y: Primary prostatic endodermal sinus tumor (yolk sac tumor) combined with a small focal seminoma. Am J Surg Pathol 2003;27:554-559.
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