Paraneoplastic syndromes (PNSs) are rare disorders which are triggered by an altered immune system response to a neoplasm. Although prostate cancer (PCa) is the second most common urological malignancy associated with PNSs, literature is lacking in defining the cases representing different PNSs in PCa. Herein, we present a 50-year-old man with fulminant distal phalangeal necrosis in the lower extremities after a diagnosis of PCa. Additionally, we review the literature in light of this case.

1.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
2.
Heidenreich A, Witjes WP, Bjerklund-Johansen TE, Patel A; EAU Research Foundation: Therapies used in prostate cancer patients by European urologists: data on indication with a focus on expectations, perceived barriers and guideline compliance related to the use of bisphosphonates. Urol Int 2012;89:30-38.
3.
Hong MK, Kong J, Namdarian B, Longano A, Grummet J, Hovens CM, Costello AJ, Corcoran NM: Paraneoplastic syndromes in prostate cancer. Nat Rev Urol 2010;7:681-692.
4.
Eskicorapci SY, Guliyev F, Islamoglu E, Ergen A, Ozen H: The effect of prior biopsy scheme on prostate cancer detection for repeat biopsy population: results of the 14-core prostate biopsy technique. Int Urol Nephrol 2007;39:189-195.
5.
Van der Kwast TH, Amin MB, Billis A, Epstein JI, Griffiths D, Humphrey PA, Montironi R, Wheeler TM, Srigley JR, Egevad L, Delahunt B; ISUP Prostate Cancer Group: International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume. Mod Pathol 2011;24:16-25.
6.
O'Donnell JR, Keaveny TV, O'Connell LG: Digital arteritis as a presenting feature of malignant disease. Ir J Med Sci 1980;149:386-390.
7.
Paolini MV, Jankilevich G, Graziano C, Fernández Romero DS: Fulminant digital necrosis in a patient with prostate adenocarcinoma. Allergol Immunopathol (Madr) 2010;38:48-50.
8.
Sun NC, McAfee WM, Hum GJ, Weiner JM: Hemostatic abnormalities in malignancy, a prospective study of one hundred eight patients. Part I. Coagulation studies. Am J Clin Pathol 1979;71:10-16.
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