Objective: We studied the relationship between penile hemodynamic parameters assessed by color Doppler ultrasonography and penile rigidity estimated by objective measurement. Patients and Methods: A total 37 patients with erectile dysfunction were examined. After intracavernous injection of 20 µg prostaglandin E1, we measured their penile hemodynamic parameters in the cavernous arteries by color Doppler ultrasonography. Simultaneously, the RigiScan Plus device was used for real-time evaluation of penile rigidity. Hemodynamic parameters were correlated with penile rigidity. Results: Peak systolic velocity and resistive index were significantly correlated with penile tip (r = 0.54, r = 0.72, respectively) and base (r = 0.55, r = 0.76, respectively) rigidity; there was no significant correlation between end-diastolic velocity and penile rigidity. Conclusions: Peak systolic velocity and resistive index were strongly correlated with penile rigidity in patients with erectile dysfunction during intracavernous pharmacological testing. The resistive index in particular appeared to be the most valid parameter for assessment of penile rigidity.

Virag R, Frydman D, Legman M, Virag H: Intracavernous injection of papaverine as a diagnostic and therapeutic method in erectile failure. Angiology 1984;35:79–87.
Lue TM, Hricak H, Marich KW, Tanagho EA: Vasculogenic impotence evaluated by high-resolution ultrasonography and pulsed Doppler spectrum analysis. Radiology 1985;155:777–781.
Speel TGW, van Langen H, Wijkstra H, Meuleman EJH: Penile duplex pharmaco-ultrasonograhpy revisited: Revalidation of the parameters of the cavernous arterial response. J Urol 2003;169:216–220.
Meuleman EJH, Bemelmans BLH, van Asten WNJC, Doesburg WH, Skotnicki SH, Debruyne FMJ: Assessment of penile blood flow by duplex ultrasonography in 44 men with normal erectile potency in different phases of erection. J Urol 1992;147:51–56.
El-Sakka AI: Penile axial rigidity and Doppler ultrasonography parameters in patients with erectile dysfunction: Association with type 2 diabetes. Urology 2003;62:525–531.
Basar MM, Atan A, Tekdogan ÜY, Batislam E: A classification based on peak systolic velocity and end diastolic velocity predicts sildenafil citrate success. Scand J Urol Nephrol 2003;37:502–506.
Aversa A, Isidori AM, Caprio M, Cerilli M, Frajese V, Fabbri A: Penile pharmacotesting in diagnosing male erectile dysfunction: Evidence for lack of accuracy and specificity. Int J Androl 2002;25:6–10.
Levine LA, Lenting EL: Use of nocturnal penile tumescence and rigidity in the evaluation of male erectile dysfunction. Urol Clin North Am 1995;22:775–788.
Chiou RK, Pomeroy BD, Chen WS, Anderson JC, Wobig RK, Taylor RJ: Hemodynamic patterns of pharmacologically induced erection: Evaluation by color Doppler sonography. J Urol 1998;159:109–112.
McMahon CG: Correlation of penile duplex ultrasonography, PBI, DICC and angiography in the diagnosis of impotence. Int J Impot Res 1998;10:153–158.
Paushter DM: Role of Duplex sonography in the evaluation of sexual impotence. Am J Roentgenol 1989;153:1161–1163.
Schwartz AN, Wang KY, Mack LA, Lowe M, Berger RE, Cyr DR, Feldman M: Evaluation of normal erectile function with color flow Doppler sonography. Am J Roentgenol 1989;153:1155–1160.
Chen JH, Liu SP, Hsieh JT: The relationship of penile rigidity and intracavernous vascular resistance in potent men during intracavernous pharmacological testing. J Urol 2001;166:1762–1765.
Erdoğru T, Savas M, Yilmaz N, Baykara M: Are normal hemodynamic responses invariably associated with normal penile rigidity and potency? Int J Impot Res 2001;13:10–15.
Hatzichristou DG, Hatzimouratidis K, Tzortzis V, Apostolidis A, Bekos A, Ioannidis E: Normal hemodynamic parameters do not always predict the presence of a rigid erection: A quantitative assessment of functional erectile impairment. Int J Impot Res 2003;15:99–104.
Andersson KE, Wagner G: Physiology of penile erection. Physiol Rev 1995;75:191–236.
Kassouf W, Carrier S: A comparison of the International Index of Erectile Function and erectile dysfunction studies. BJU Int 2003;91:667–669.
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