To verify if uremia per se influences the eventual outcome of bacterial challenge, we have set up an experimental model of infection in rats with surgically induced uremia and controls. Our preliminary results indicate that both uremic and control rats die at the same rate when challenged intraperitoneally with LD50 of a Pseudomonas strain. These observations would suggest that uremia per se is not a major determinant of the increased incidence of infectious complications as has been noted in this condition.

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