Objective: To observe the morphological changes in paraurethral ducts infected with gonococci in men before and after the administration of the ceftriaxone therapy using high-frequency ultrasound and determine its clinical significance. Methods: Thirty-two male patients with gonococcal paraurethral duct infection were enrolled. Their lesions were examined using an ACUSON X300 ultrasound system before and after they were subjected to ceftriaxone therapy. Results: The paraurethral duct was completely closed 3–4 days after ceftriaxone treatment in 30 patients. Paraurethral duct closure began from the blind end and proceeded gradually towards its orifice; during closure, the paraurethral duct diameter showed no apparent change. These 30 patients whose paraurethral ducts closed were considered cured. In the remaining 2 patients, the length and diameter of the paraurethral ducts showed no change before and after ceftriaxone treatment; one patient was unresponsive to ceftriaxone treatment, and the other had secondary dilatation of the paraurethral duct. These 2 patients were cured after surgery. Conclusion: High-frequency ultrasound enables dynamic observation of the morphological changes in paraurethral ducts infected with gonococci before and after ceftriaxone therapy. High-frequency ultrasound can provide valuable information for incision, drainage, and wedge resection of paraurethral ducts.

Ambrose K, Claude N: Venereal Diseases, ed 2. Philadelphia, Davis, 1969, p 161.
Harkness AH: The pathology of gonorrhoea. Br J Vener Dis 1948; 24: 137–147.
Gilhooly P, Hensle TW: Parameatal ducts of glans penis. Structure, symptoms, and treatment of uncommon focus of infection. Urology 1984; 24: 375–378.
Fan W: Gonococcal inflammation of paraurethral glands around external urethral orifice in males: a commonly encountered disease? Int J STD AIDS 2010; 21: 225–226.
Fan W, Zhang Q, Fan Z: Sequential therapy for gonococci inflammation of paraurethral glands in males. J Dermatolog Treat 2012; 23: 184–188.
Fan W, Zhang Q: Risk factors for male patients with gonorrhoea complicated by inflammation of the paraurethral glands around the external urethral orifice. Int J STD AIDS 2012; 23: 400–402.
Fan W, Zhang Q, Jiang T: Pathogen profile in men with inflammation of paraurethral glands. Sex Transm Infect 2014; 90: 52–54.
Sherrard J: Gonorrhoea. Medicine 2014; 42: 323–326.
Fan W, Zhang Q, Ye X: High-frequency ultrasound findings in gonococcal inflammation of the paraurethral glands in men. J Eur Acad Dermatol Venereol 2016; 30: 146–147.
Fan W, Zhang Q: Bilateral inflammation of the paraurethral glands around the external urethral orifice due to Chlamydia trachomatis in a male. Int J Dermatol 2013; 52: 1567–1568.
Bruhns C: Rieckes Lehrbuck der Haut und Geschlechts-Krankheiten. Jena, Gustav Fisher, 1931, pp 710–713.
Fan W, Zhang Q, Wang L, et al: Sequelae of gonococcal inflammation of the paraurethral glands in men: paraurethral duct dilatation. Sex Transm Infect 2015; 91: 193.
Fan W, Zhang Q, Song L: Acquired microcyst in the paraurethral glands of a male patient. Int J STD AIDS 2013; 24: 159–160.
Fan W, Zhang Q, Wang L, et al: Risk factors associated with paraurethral duct dilatation following gonococcal paraurethral duct infection in men. PLoS One 2016; 11:e0166355.
Strevinas A, Reid AJ, McGrouther DA. Sinus tract identification by methylene blue gel. J Plast Reconstr Aesthet Surg 2013; 66:e297.
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