... of a known clinical insult or presents with new/worsening respiratory symptoms if the clinical insult is unknown. Approximately 40% of the ARDS cases have a fatal outcome. Transfusion-related acute lung injury (TRALI), on the other hand, is characterized by the occurrence of respiratory distress and acute...

... and about 97% of Caucasian individuals express the CD177 glycoprotein on their neutrophils while the rest are completely devoid of HNA-2 [ 1,57,58 ]. Only HNA-2 deficient (HNA-2null) [ 59 ] individuals are able to produce HNA-2 isoantibodies that can cause TRALI and immune neutropenia [ 3,60 ]. However...

...Teresa Jimenez-Marco; Daniel Ruiz-Alderton; Antonia M. Bautista-Gili; Enrique Girona-Llobera Introduction: Risk reduction strategies for transfusion-related acute lung injury (TRALI) include the preferential use of male donors to provide fresh frozen plasma (FFP). Implementing this measure based...

... from any ideas, methods, instructions or products referred to in the content or advertisements. In view of the early observation that the plasma-rich components, such as fresh frozen plasma and apheresis platelets, have been most frequently implicated in TRALI induction, as well as on the basis...

... on a standardised form is mandatory. Data are then analysed to estimate the risks of the most serious transfusion events. Together with transfusion of an incorrect blood component and bacterial contamination of platelet concentrates, TRALI is a significant risk of transfusion in Switzerland and occurs...

... established in 1994 and records all adverse events associated with the transfusion of a labile blood products (LBP) regardless of their severity. From 1994 to 2006 35,423,172 LBP were issued, 85,812 adverse transfusion reactions notified, and 139 cases of transfusion related acute lung injury (TRALI) observed...

...Catherine Eluned Chapman; Lorna M. Williamson This article describes the TRALI reduction policies which were introduced by the National Blood Service in late 2003. Consideration was given to the reasons for their introduction and how the changes were implemented. The observed effects which followed...