...Johanna Kirschall; Günalp Uzun; Tamam Bakchoul; Irene Marini Background: Transfusion of platelets is a life-saving medical strategy used worldwide to treat patients with thrombocytopenia as well as platelet function disorders. Summary: Until the end of 1960s, platelets were stored in the cold...

...Johannes-Moritz von Behren; Jan Wesche; Andreas Greinacher; Konstanze Aurich Introduction: Before being implemented in daily clinical routine, new production strategies for platelet concentrates (PCs) must be validated for their efficacy. Besides in vitro testing, the establishment of new methods...

...Julia Zeller-Hahn; Anna Kobsar; Marius Bittl; Angela Koessler; Katja Weber; Markus Boeck; Juergen Koessler Introduction: Refrigeration of platelets is considered to provide advantages in therapy of acute hemorrhage due to increased platelet responsiveness. The alleviation of inhibitory signaling...

...) is an important part of blood coagulation since it binds platelets to each other and to endothelial cells. In traumatic and surgical haemorrhage, both blood cells and plasmatic factors are consumed, leading to consumption coagulopathy and fluid resuscitation. This often results in large amounts of crystalloids...

... platelet count on postpartum hemorrhage. We have shown prepartum coagulation factor XIII to be associated with postpartum blood loss; however, little is known about the association of platelet count with factor XIII activity. Our objectives were, first, to evaluate the impact of prepartum platelet count...

...Demin Liu; Dongguo Pei; Haijuan Hu; Guoqiang Gu; Wei Cui Background: Platelet activation occurs upon ischemia/reperfusion and is related to the generation of reactive oxygen species (ROS) during this process. Vitamin C (VC) is a powerful antioxidant. VC scavenges ROS, reduces platelet activation...

... to be considered for the blood supply of immunized or chronically transfused patients. It also applies for platelet antigens (HPA) and neutrophil antigens (HNA) for patients receiving platelet or granulocyte concentrates. Here, we describe the molecular screening for a number of blood group, HPA, and HNA alleles...

...Maria Clara Fernandes Silva-Malta; Lucas Gabriel Tavares de Oliveira; Luísa Ferreira Barreiros; Dilson Rocha do Amaral; Marina Lobato Martins Summary Background: The frequency of human platelet antigens (HPA) varies according to ethnicity, which causes differences in the morbidity of alloimmune...

...: Activation of platelets from healthy volunteers was assessed by flow cytometry analysis of fibrinogen binding and CD62P expression. Platelet CXCL4 release was measured by ELISA. Human peripheral blood mononuclear cells were exposed to CXCL4 or platelet supernatants (untreated or pre-stimulated with factor...

.... Thus, it is impossible to determine when the primary tumor first developed and when the onset of tumor-associated dysregulation occurred for the first time. Since platelets are also involved in the process of malignancies [ 16,17 ,] it remains unclear which disease is the primary and which...

...Julia Barbara Kral; Waltraud Cornelia Schrottmaier; Manuel Salzmann; Alice Assinger Summary Beyond their traditional role in haemostasis and thrombosis, platelets are increasingly recognised as immune modulatory cells. Activated platelets and platelet-derived microparticles can bind to leukocytes...

...Barbara Lehner; Beate Eichelberger; Christof Jungbauer; Simon Panzer Summary Background: The extent of expression of the blood group A on platelets is controversial. Further, the relation between platelets' blood group A expression and the titers of isoagglutinins has not been thoroughly...

...Joan Cid; Sarah K. Harm; Mark H. Yazer Many modern therapies depend on platelet (PLT) transfusion support. PLTs have a 4- to 7-day shelf life and are frequently in short supply. In order to optimize the inventory PLTs are often transfused to adults without regard for ABO compatibility. Hemolytic...

...Mark Roest; Thijs C. van Holten; Ger-Jan Fleurke; Jasper A. Remijn Background: Platelet concentrate transfusion is the standard treatment for hemato-oncology patients to compensate for thrombocytopenia. We have developed a novel platelet activation test in anticoagulated unprocessed blood (pac-t-UB...

...Marija Borosak; Erica Wood The risk of bacterial transmission by platelet transfusion has been recognised internationally as the leading residual infections transfusion risk in the last decade. We describe the clinical and logistical aspects of bacterial contamination screening of platelets...

..., a comprehensive pre-clinical and clinical development and an ongoing hemovigilance program. Material and Methods: The INTERCEPT Blood System utilizes amotosalen and UVA light and enables for the treatment of platelets and plasma in the same device. Preclinical studies of pathogen inactivation and toxicology...

...Max-Joseph Kraus; Erwin F. Strasser; Reinhold Eckstein Background: Platelet shape change is a dynamic process that has been classified in different types. Exact documentation of platelet structure needs an improved method of measuring platelet shape. Methods: 10 ml of platelet-rich plasma (PRP...

...Christian Hintze; Brigitte Rüster; Erhard Seifried; Reinhard Henschler Background: Whereas ex vivo expanded megakaryocytic progenitor cells have been investigated for their ability to support platelet regeneration, the question whether more mature platelet-like particles expanded from hematopoietic...

... plasma-derived preparations. Proteins identified in some of the plasma-derived concentrates included up to 90 ng/IU of the anaphylatoxin C3a, up to 40 ng/IU of the platelet Α-granule protein thrombospondin-1, up to 0.85 ng/IU of the platelet agranule protein platelet factor 4, 3.5 ng/IU myeloperoxidase...

...N.A. Smith; M. Watts; A.W. Simpson; B.J. Boughton 15 patients underwent plasma exchange using a standard 170-μm in-line filter with or without an additional 40-μm microaggregate filter in the return circuit. The mean platelet count fall immediately after plasma exchange in 15 patients was (54 ± 6...