... life and varying daily fluctuations in consumption, the storage of platelet concentrates (PCs) becomes challenging. This emphasizes the need for reliable prediction of needed PCs for the blood bank inventories. Therefore, the objective of this study was to evaluate multimodal data from multiple source...

...Sarah Anna Fiedler; Klaus Boller; Ann-Christine Junker; Christel Kamp; Anneliese Hilger; Wolfgang Schwarz; Rainer Seitz; Ursula Salge-Bartels Background: Platelet concentrates play an important role in transfusion medicine. Their short lifespan and lack of robustness require efforts to ensure...

... reported. Especially platelet concentrates are highly susceptible to bacterial contaminations due to the growth-promoting storage conditions. In Europe, blood establishments and national authorities have implemented individual precaution measures to mitigate the risk of bacterial transmission. To obtain...

...Tanja Vollmer; Dennis Hinse; Jürgen Diekmann; Cornelius Knabbe; Jens Dreier The shelf life of platelet concentrates (PCs) was limited in Germany to 4 days after the day of production because platelet-related septic complications had been observed, mainly with PCs at the end of their shelf life...

...Markus Jutzi; Behrouz Mansouri Taleghani; Morven Rueesch; Lorenz Amsler; Andreas Buser Summary Introduction : Bacterial contamination of platelet concentrates (PCs) has been identified as the most prevalent transfusion-associated infectious risk. To prevent PC-related septic transfusion reactions...

... populations in platelet concentrates (PCs), this study investigates the correlation of ROS generation with the expression and release of platelet activation markers during storage. Methods: Samples obtained from 6 PCs were subjected to flow cytometry and ELISA to evaluate the expression and shedding...

.... UVC Pathogen inactivation Platelet concentrates Plasma carryover Pathogen inactivation (PI) methods attempt to prevent the replication of pathogens in blood components, thereby reducing the risk of transfusion-transmitted infection (reviewed in [ 1 ]). The INTERCEPT and Mirasol systems use...

... factors became evident. Since that time the implementation of measures for risk prevention and safety precaution was socially and politically accepted. Currently emerging pathogens like arboviruses and the well-known bacterial contamination of platelet concentrates still remain major concerns of blood...

... achieved due to the introduction of mandatory virus screening. Platelet concentrates (PCs) represent one of the highest risks for bacterial infection. This is due to the required storage conditions for PCs in gas-permeable containers at room temperature with constant agitation, which support bacterial...

...Mark Roest; Thijs C. van Holten; Ger-Jan Fleurke; Jasper A. Remijn Background: Platelet concentrate transfusion is the standard treatment for hemato-oncology patients to compensate for thrombocytopenia. We have developed a novel platelet activation test in anticoagulated unprocessed blood (pac-t-UB...

... will summarize the different fields in which platelet function testing is currently in use; diagnostics of patients with bleeding disorders, monitoring patients' response to anti-platelet therapy, monitoring in transfusion medicine (blood donors, platelet concentrates, and after transfusion), and monitoring...

..., contributes to the global coagulation potential of these blood components. The present study evaluated, for the first time, the expression of TF on platelet surface during preparation and storage of platelet concentrates (PC) for transfusional use. Methods : Platelet TF was measured by flow cytometry...

...Andrea Doescher; Thomas H. Müller Background: New technology introduces the option to measure pH in platelet concentrates noninvasively. Findings that in one out of 25 apheresis concentrates the pH decreased significantly during storage motivated us to evaluate apheresis concentrates from 307...

... are described. Methods: All platelet concentrates were cultured with the BacT/Alert culturing system with large volume (7.5 ml) cultures in either an aerobic or an anaerobic bottle. Products were released on a ‘negative-to-date’ basis. Results: After introduction of the diversion of the first milliliters...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Pathogen inactivation UVC Platelet concentrates Plasma Blood units Review Article · Übersichtsarbeit Transfus Med Hemother 2011;38:43 54 DOI: 10.1159/000323845 Received: October 29, 2010...

...Karin Janetzko; Katharina Hinz; Susanne Marschner; Ray Goodrich; Harald Klüter Background: The Mirasol® pathogen reduction technology (PRT) for platelet concentrates (PC) uses riboflavin and UV light (270–360 nm). We evaluated the impact of PRT on platelets in comparison to standard single-donor PC...

... to about 15% was acceptable. Cell separator Platelet concentrates Leukocyte contamination © 1991 S. Karger AG, Basel 1991 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Platelet concentrates Single-needle apheresis Plateletpheresis Thrombocytapheresis...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Thrombocytapheresis Plateletpheresis Donor apheresis Platelet concentrates Platelet yield Continuous flow centrifugation ...

...M. Aulmann; K. Ruf Inhibition of phosphatases 1/2A (ppl/2A) by okadaic acid (OA) prevents thrombin-or collagen-stimulated platelet aggregation, serotonin and ATP release, as well as intracellular Ca2+ increase. OA is added to 12 platelet concentrates (PCs) prepared from 500 ml whole blood...