Je 6 Kontrollpersonen, Leberkranke und Patienten mit Diabetes mellitus erhalten eine 20%ige Mischlösung (Glukose : Fruktose : Xylit = 1:2:1) über eine Periode von 48 Stunden infundiert. 39 Stoffwech-selkenngrößen werden in regelmäßigen Intervallen kontrolliert. Die Sollzufuhr des Gesamtgemisches ist mit 0,25 g/kg KG und Stunde vorgegeben. Die Blutglukosekonzentrationen ändern sich in keiner der 3 Gruppen wesentlich. Laktat- und Triglyceridwerte tendieren zu einem geringen, kontinuierlichen Anstieg. Freie Fettsäuren und Ketonkörper werden auf niedrige Werte supprimiert. Nur bei den Diabetikern kommt es mit 15% zu erheblichen Kohlenhydratverlusten über die Niere. Klinisch relevante Nebenwirkungen sind nicht aufgefallen.

Keywords:
Langzeítinfusion, Glukose, Xylit, Fruktose
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© 1982 S. Karger AG, Basel
1982
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