Neben dem notwendigen Volumeneffekt (isoosmotische und isoonkotische Lösung) und der physiologischen Bicarbonatkonzentration (Verhinderung der Dilutions-Azidose) sollte eine potentielle Blut-Ersatzlösung mit O2-Trägereigenschaften einen optimalen O2-Transport ermöglichen: Viskosität so niedrig wie möglich und unabhängig vom Schergrad (Newton’sches Verhalten), O2-Konzentration beim gegebenen O2-Partialdruck mindestens 6 ml/dl und mittlerer kapillärer O2-Partialdruck so hoch wie möglich. Zur Beurteilung eines derartigen Blut-Ersatzes wird der sogenannte O2-Versorgungsindex vorgeschlagen, das Produkt aus O2-Konzentration und mittlerem kapillärem O2-Partialdruck dividiert durch die Viskosität.

Keywords:
Blut-Ersatz, Sauerstoff, Viskosität, Säure-Basen-Haushalt, Durch-blutung
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© 1981 S. Karger AG, Basel
1981
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