Die biochemischen Grundlagen des Stoffwechsels von Glukose und Nicht-Glukose-Kohlenhydraten (Fruktose, Sorbit, Xylit) und die möglichen Nachteile einer hochdosierten parenteralen Gabe dieser Kohlenhydrate bei internistischen Patienten, wie sie sich aus Unter-suchungen an perfundierten Organen und Tieren sowie aus Einzelfall-beschreibungen beim Menschen ergeben könnten, werden dargestellt. DieseÜberlegungensinddieGrundlagefürUntersuchungenbeiinter-nistischen Patienten (Leberzirrhose, Diabetes mellitus) und stoffwechselgesunden Kontrollen, in denen die Verträglichkeit sowie Art und Ausmaβ von Nebenwirkungen einer niedrigdosierten, langfristigen parenteralen Gabe von Glukose oder Kohlenhydratgemischen gepriift wurde. Die Ergebnisse dieser Untersuchungen werden in weiteren Mitteilungen dargestellt.

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