Postoperativ und posttraumatisch kommt es zu deutlichen Verschiebungen des Aminosäuren(AS)-Gleichgewichtes mit zum Teil deutlichen Blutspiegefimbalanzen. Um die Ursache dieser Veränderungen zu klären, führten wir bei 19 gesunden Erwachsenen und bei 20 Patienten am 2. postoperativen Tag pharmakokinetische Untersuchungen über die AS-Verwertung durch. Es zeigte sich, daβ postoperativ die meisten AS längere Halbwertzeiten haben und entsprechend die Clearance reduziert ist. Die Notwendigkeit spezieller AS-Lösungen für postoperative Patienten wird diskutiert.

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