Bei jeweils 8 freiwilligen Versuchspersonen wurden die beiden Fettemulsionen Intralipid und Lipofundin S in einer Dosierung von 0,1 g/kg KG × h (jeweils 12 Std.) und 0,25 g/kg KG × h (jeweils 8 Std.) intravenös verabreicht. In beiden Dosierungen wird Intralipid deutlich langsamer aus dem Blut eliminiert wie Lipofundin S. Es ist daher erforderlich für beide Fettemulsionen unterschiedliche Dosie-rungsrichtlinien festzulegen, wobei frühere Empfehlungen anderer Autoren für Intralipid sich als überhöht erwiesen. Ferner wird eine strenge Überwachung der Patienten während parenteraler Fettver-abreichung gefordert. Bei stärkerem Anstieg der Triglyzeridkonzentration bzw. bei Auftreten einer Lipämie sollten die Fettinfusionen sofort abgebrochen werden.

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