Background and Summary: Extracorporeal photopheresis (ECP) is a leukapheresis-based procedure used in the therapy of acute and chronic graft-versus-host disease (aGvHD, cGvHD) and other diseases. Based on the substantial efficacy and the excellent safety profile in the absence of immunosuppression ECP has established itself as a major treatment form for steroid-refractory GvHD. Here we review the current literature on ECP as a treatment option for patients with aGvHD as well as cGvHD. Key Messages: ECP is a well-established second-line therapy for cGvHD. Its role in the treatment of aGvHD is less clear but also points towards an effective second-line therapy option. In the future ECP could play a role in the prevention of GvHD. More experimental and randomized controlled trials are needed to define the best patient selection criteria, settings, and therapy regimens for GvHD.

1.
Zeiser
R
,
Blazar
BR
.
Acute Graft-versus-Host Disease - Biologic Process, Prevention, and Therapy
.
N Engl J Med
.
2017
Nov
;
377
(
22
):
2167
79
.
[PubMed]
0028-4793
2.
Zeiser
R
,
Blazar
BR
.
Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets
.
N Engl J Med
.
2017
Dec
;
377
(
26
):
2565
79
.
[PubMed]
0028-4793
3.
Richard
EG
.
The Science and (Lost) Art of Psoralen Plus UVA Phototherapy
.
Dermatol Clin
.
2020
Jan
;
38
(
1
):
11
23
.
[PubMed]
0733-8635
4.
Edelson
R
,
Berger
C
,
Gasparro
F
,
Jegasothy
B
,
Heald
P
,
Wintroub
B
, et al.
Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results
.
N Engl J Med
.
1987
Feb
;
316
(
6
):
297
303
.
[PubMed]
0028-4793
5.
Menkes
CJ
,
Andreu
G
,
Heshmati
F
,
Hilliquin
P
.
Extracorporeal photochemotherapy
.
Br J Rheumatol
.
1992
Nov
;
31
(
11
):
789
90
.
[PubMed]
0263-7103
6.
Rook
AH
,
Freundlich
B
,
Jegasothy
BV
,
Perez
MI
,
Barr
WG
,
Jimenez
SA
, et al.
Treatment of systemic sclerosis with extracorporeal photochemotherapy. Results of a multicenter trial
.
Arch Dermatol
.
1992
Mar
;
128
(
3
):
337
46
.
[PubMed]
0003-987X
7.
Knobler
RM
.
Extracorporeal photochemotherapy for the treatment of lupus erythematosus: preliminary observations
.
Springer Semin Immunopathol
.
1994
;
16
(
2-3
):
323
5
.
[PubMed]
0344-4325
8.
Owsianowski
M
,
Gollnick
H
,
Siegert
W
,
Schwerdtfeger
R
,
Orfanos
CE
.
Successful treatment of chronic graft-versus-host disease with extracorporeal photopheresis
.
Bone Marrow Transplant
.
1994
Nov
;
14
(
5
):
845
8
.
[PubMed]
0268-3369
9.
Knobler
R
,
Berlin
G
,
Calzavara-Pinton
P
,
Greinix
H
,
Jaksch
P
,
Laroche
L
, et al.
Guidelines on the use of extracorporeal photopheresis
.
J Eur Acad Dermatol Venereol
.
2014
Jan
;
28
Suppl 1
:
1
37
.
[PubMed]
0926-9959
10.
Padmanabhan
A
,
Connelly-Smith
L
,
Aqui
N
,
Balogun
RA
,
Klingel
R
,
Meyer
E
, et al.
Guidelines on the Use of Therapeutic Apheresis in Clinical Practice - Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue
.
J Clin Apher
.
2019
Jun
;
34
(
3
):
171
354
.
[PubMed]
0733-2459
11.
Hackstein
H
,
Amoros
JJ
,
Bein
G
,
Woessmann
W
.
Successful use of miniphotopheresis for the treatment of graft-versus-host disease
.
Transfusion
.
2014
Aug
;
54
(
8
):
2022
7
.
[PubMed]
0041-1132
12.
Bladon
J
,
Taylor
PC
.
Extracorporeal photopheresis induces apoptosis in the lymphocytes of cutaneous T-cell lymphoma and graft-versus-host disease patients
.
Br J Haematol
.
1999
Dec
;
107
(
4
):
707
11
.
[PubMed]
0007-1048
13.
Gerber
A
,
Bohne
M
,
Rasch
J
,
Struy
H
,
Ansorge
S
,
Gollnick
H
.
Investigation of annexin V binding to lymphocytes after extracorporeal photoimmunotherapy as an early marker of apoptosis
.
Dermatology
.
2000
;
201
(
2
):
111
7
.
[PubMed]
1018-8665
14.
Durazzo
TS
,
Tigelaar
RE
,
Filler
R
,
Hayday
A
,
Girardi
M
,
Edelson
RL
.
Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: initiation via direct platelet signaling
.
Transfus Apheresis Sci
.
2014
Jun
;
50
(
3
):
370
8
.
[PubMed]
1473-0502
15.
Spisek
R
,
Gasova
Z
,
Bartunkova
J
.
Maturation state of dendritic cells during the extracorporeal photopheresis and its relevance for the treatment of chronic graft-versus-host disease
.
Transfusion
.
2006
Jan
;
46
(
1
):
55
65
.
[PubMed]
0041-1132
16.
Edelson
R
,
Wu
Y
,
Schneiderman
J
.
American council on ECP (ACE): why now?
J Clin Apher
.
2018
Aug
;
33
(
4
):
464
8
.
[PubMed]
0733-2459
17.
Vowels
BR
,
Cassin
M
,
Boufal
MH
,
Walsh
LJ
,
Rook
AH
.
Extracorporeal photochemotherapy induces the production of tumor necrosis factor-alpha by monocytes: implications for the treatment of cutaneous T-cell lymphoma and systemic sclerosis
.
J Invest Dermatol
.
1992
May
;
98
(
5
):
686
92
.
[PubMed]
0022-202X
18.
Biagi
E
,
Di Biaso
I
,
Leoni
V
,
Gaipa
G
,
Rossi
V
,
Bugarin
C
, et al.
Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4+CD25+GITR+Foxp3+CD62L+ functional regulatory T-cells in patients with graft-versus-host disease
.
Transplantation
.
2007
Jul
;
84
(
1
):
31
9
.
[PubMed]
0041-1337
19.
Gatza
E
,
Rogers
CE
,
Clouthier
SG
,
Lowler
KP
,
Tawara
I
,
Liu
C
, et al.
Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells
.
Blood
.
2008
Aug
;
112
(
4
):
1515
21
.
[PubMed]
0006-4971
20.
Hannani
D
.
Extracorporeal Photopheresis: Tolerogenic or Immunogenic Cell Death? Beyond Current Dogma
.
Front Immunol
.
2015
Jul
;
6
:
349
.
[PubMed]
1664-3224
21.
Marshall
SR
.
Technology insight: ECP for the treatment of GvHD—can we offer selective immune control without generalized immunosuppression?
Nat Clin Pract Oncol
.
2006
Jun
;
3
(
6
):
302
14
.
[PubMed]
1743-4254
22.
Worel
N
,
Mansouri Taleghani
B
,
Strasser
E
.
Recommendations for Therapeutic Apheresis by the Section “Preparative and Therapeutic Hemapheresis” of the German Society for Transfusion Medicine and Immunohematology
.
Transfus Med Hemother
.
2019
Dec
;
46
(
6
):
394
406
.
[PubMed]
1660-3796
23.
Pavletic
SZ
,
Vogelsang
GB
,
Lee
SJ
.
2014 National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: preface to the series
.
Biol Blood Marrow Transplant
.
2015
Mar
;
21
(
3
):
387
8
.
[PubMed]
1083-8791
24.
Jagasia
MH
,
Greinix
HT
,
Arora
M
,
Williams
KM
,
Wolff
D
,
Cowen
EW
, et al.
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant.
2015
;21(3):389-401 e1.
25.
Alfred
A
,
Taylor
PC
,
Dignan
F
,
El-Ghariani
K
,
Griffin
J
,
Gennery
AR
, et al.
The role of extracorporeal photopheresis in the management of cutaneous T-cell lymphoma, graft-versus-host disease and organ transplant rejection: a consensus statement update from the UK Photopheresis Society
.
Br J Haematol
.
2017
Apr
;
177
(
2
):
287
310
.
[PubMed]
0007-1048
26.
Dignan
FL
,
Amrolia
P
,
Clark
A
,
Cornish
J
,
Jackson
G
,
Mahendra
P
, et al.;
Haemato-oncology Task Force of British Committee for Standards in Haematology
;
British Society for Blood and Marrow Transplantation
.
Diagnosis and management of chronic graft-versus-host disease
.
Br J Haematol
.
2012
Jul
;
158
(
1
):
46
61
.
[PubMed]
0007-1048
27.
Wolff
D
,
Schleuning
M
,
von Harsdorf
S
,
Bacher
U
,
Gerbitz
A
,
Stadler
M
, et al.
Consensus Conference on Clinical Practice in Chronic GVHD: Second-Line Treatment of Chronic Graft-versus-Host Disease
.
Biol Blood Marrow Transplant
.
2011
Jan
;
17
(
1
):
1
17
.
[PubMed]
1083-8791
28.
Miller
KB
,
Roberts
TF
,
Chan
G
,
Schenkein
DP
,
Lawrence
D
,
Sprague
K
, et al.
A novel reduced intensity regimen for allogeneic hematopoietic stem cell transplantation associated with a reduced incidence of graft-versus-host disease
.
Bone Marrow Transplant
.
2004
May
;
33
(
9
):
881
9
.
[PubMed]
0268-3369
29.
Shaughnessy
PJ
,
Bolwell
BJ
,
van Besien
K
,
Mistrik
M
,
Grigg
A
,
Dodds
A
, et al.
Extracorporeal photopheresis for the prevention of acute GVHD in patients undergoing standard myeloablative conditioning and allogeneic hematopoietic stem cell transplantation
.
Bone Marrow Transplant
.
2010
Jun
;
45
(
6
):
1068
76
.
[PubMed]
0268-3369
30.
Kitko
CL
,
Braun
T
,
Couriel
DR
,
Choi
SW
,
Connelly
J
,
Hoffmann
S
, et al.
Combination Therapy for Graft-versus-Host Disease Prophylaxis with Etanercept and Extracorporeal Photopheresis: Results of a Phase II Clinical Trial
.
Biol Blood Marrow Transplant
.
2016
May
;
22
(
5
):
862
8
.
[PubMed]
1083-8791
31.
Michallet
M
,
Sobh
M
,
Garban
F
,
Bulabois
CE
,
Yakoub-Agha
I
,
Coiteux
V
, et al.
Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study
.
Leuk Lymphoma
.
2018
Feb
;
59
(
2
):
372
80
.
[PubMed]
1042-8194
32.
Jagasia
M
,
Scheid
C
,
Socié
G
,
Ayuk
FA
,
Tischer
J
,
Donato
ML
, et al.
Randomized controlled study of ECP with methoxsalen as first-line treatment of patients with moderate to severe cGVHD
.
Blood Adv
.
2019
Jul
;
3
(
14
):
2218
29
.
[PubMed]
2473-9529
33.
Foss
FM
,
DiVenuti
GM
,
Chin
K
,
Sprague
K
,
Grodman
H
,
Klein
A
, et al.
Prospective study of extracorporeal photopheresis in steroid-refractory or steroid-resistant extensive chronic graft-versus-host disease: analysis of response and survival incorporating prognostic factors
.
Bone Marrow Transplant
.
2005
Jun
;
35
(
12
):
1187
93
.
[PubMed]
0268-3369
34.
Flowers
ME
,
Apperley
JF
,
van Besien
K
,
Elmaagacli
A
,
Grigg
A
,
Reddy
V
, et al.
A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease
.
Blood
.
2008
Oct
;
112
(
7
):
2667
74
.
[PubMed]
0006-4971
35.
Greinix
HT
,
van Besien
K
,
Elmaagacli
AH
,
Hillen
U
,
Grigg
A
,
Knobler
R
, et al.;
UVADEX Chronic GVHD Study Group
.
Progressive improvement in cutaneous and extracutaneous chronic graft-versus-host disease after a 24-week course of extracorporeal photopheresis—results of a crossover randomized study
.
Biol Blood Marrow Transplant
.
2011
Dec
;
17
(
12
):
1775
82
.
[PubMed]
1083-8791
36.
Malik
MI
,
Litzow
M
,
Hogan
W
,
Patnaik
M
,
Murad
MH
,
Prokop
LJ
, et al.
Extracorporeal photopheresis for chronic graft-versus-host disease: a systematic review and meta-analysis
.
Blood Res
.
2014
Jun
;
49
(
2
):
100
6
.
[PubMed]
2287-979X
37.
McLeod
BC
,
Sniecinski
I
,
Ciavarella
D
,
Owen
H
,
Price
TH
,
Randels
MJ
, et al.
Frequency of immediate adverse effects associated with therapeutic apheresis
.
Transfusion
.
1999
Mar
;
39
(
3
):
282
8
.
[PubMed]
0041-1132
38.
Cloud
TM
,
Hakim
R
,
Griffin
AC
.
Photosensitization of the eye with methoxsalen. II. Chronic effects
.
Arch Ophthalmol
.
1961
Nov
;
66
(
5
):
689
94
.
[PubMed]
0003-9950
40.
Brosig
A
,
Hähnel
V
,
Orsó
E
,
Wolff
D
,
Holler
E
,
Ahrens
N
.
Technical comparison of four different extracorporeal photopheresis systems
.
Transfusion
.
2016
Oct
;
56
(
10
):
2510
9
.
[PubMed]
0041-1132
41.
Liu
C
,
Shah
K
,
Dynis
M
,
Eby
CS
,
Grossman
BJ
.
Linear relationship between lymphocyte counts in peripheral blood and buffy coat collected during extracorporeal photopheresis
.
Transfusion
.
2013
Nov
;
53
(
11
):
2635
43
.
[PubMed]
0041-1132
42.
Robert Zeiser
DW
. Christof Scheid, Thomas Luft, Hildegard Greinix, Peter Dreger, Jürgen Finke, Ernst Holler.
2019
[Available from: https://www.onkopedia.com/de/onkopedia/guidelines/graft-versus-host-erkrankung-akut/@@guideline/html/index.html
43.
Daniel Wolff
RZ
.
Christof Scheid
.
Thomas Luft, Stephan Mielke, Peter Dreger, Jürgen Finke, Ernst Holler, Hildegard Greinix
;
2019
.
44.
Dignan
FL
,
Clark
A
,
Amrolia
P
,
Cornish
J
,
Jackson
G
,
Mahendra
P
, et al.;
Haemato-oncology Task Force of British Committee for Standards in Haematology
;
British Society for Blood and Marrow Transplantation
.
Diagnosis and management of acute graft-versus-host disease
.
Br J Haematol
.
2012
Jul
;
158
(
1
):
30
45
.
[PubMed]
0007-1048
45.
Greinix
HT
,
Worel
N
,
Just
U
,
Knobler
R
.
Extracorporeal photopheresis in acute and chronic graft-versus-host disease
.
Transfus Apheresis Sci
.
2014
Jun
;
50
(
3
):
349
57
.
[PubMed]
1473-0502
46.
Greinix
HT
,
Volc-Platzer
B
,
Kalhs
P
,
Fischer
G
,
Rosenmayr
A
,
Keil
F
, et al.
Extracorporeal photochemotherapy in the treatment of severe steroid-refractory acute graft-versus-host disease: a pilot study
.
Blood
.
2000
Oct
;
96
(
7
):
2426
31
.
[PubMed]
0006-4971
47.
Salvaneschi
L
,
Perotti
C
,
Zecca
M
,
Bernuzzi
S
,
Viarengo
G
,
Giorgiani
G
, et al.
Extracorporeal photochemotherapy for treatment of acute and chronic GVHD in childhood
.
Transfusion
.
2001
Oct
;
41
(
10
):
1299
305
.
[PubMed]
0041-1132
48.
Dall’Amico
R
,
Messina
C
.
Extracorporeal photochemotherapy for the treatment of graft-versus-host disease
.
Ther Apher
.
2002
Aug
;
6
(
4
):
296
304
.
[PubMed]
1091-6660
49.
Messina
C
,
Locatelli
F
,
Lanino
E
,
Uderzo
C
,
Zacchello
G
,
Cesaro
S
, et al.
Extracorporeal photochemotherapy for paediatric patients with graft-versus-host disease after haematopoietic stem cell transplantation
.
Br J Haematol
.
2003
Jul
;
122
(
1
):
118
27
.
[PubMed]
0007-1048
50.
Greinix
HT
,
Knobler
RM
,
Worel
N
,
Schneider
B
,
Schneeberger
A
,
Hoecker
P
, et al.
The effect of intensified extracorporeal photochemotherapy on long-term survival in patients with severe acute graft-versus-host disease
.
Haematologica
.
2006
Mar
;
91
(
3
):
405
8
.
[PubMed]
1592-8721
51.
Greinix
HT
,
Worel
N
,
Knobler
R
.
Role of extracorporeal photopheresis (ECP) in treatment of steroid-refractory acute graft-versus-host disease
.
Biol Blood Marrow Transplant
.
2010
Dec
;
16
(
12
):
1747
8
.
[PubMed]
1083-8791
52.
Garban
F
,
Drillat
P
,
Makowski
C
,
Jacob
MC
,
Richard
MJ
,
Favrot
M
, et al.
Extracorporeal chemophototherapy for the treatment of graft-versus-host disease: hematologic consequences of short-term, intensive courses
.
Haematologica
.
2005
Aug
;
90
(
8
):
1096
101
.
[PubMed]
1592-8721
53.
Kanold
J
,
Merlin
E
,
Halle
P
,
Paillard
C
,
Marabelle
A
,
Rapatel
C
, et al.
Photopheresis in pediatric graft-versus-host disease after allogeneic marrow transplantation: clinical practice guidelines based on field experience and review of the literature
.
Transfusion
.
2007
Dec
;
47
(
12
):
2276
89
.
[PubMed]
0041-1132
54.
Calore
E
,
Calò
A
,
Tridello
G
,
Cesaro
S
,
Pillon
M
,
Varotto
S
, et al.
Extracorporeal photochemotherapy may improve outcome in children with acute GVHD
.
Bone Marrow Transplant
.
2008
Sep
;
42
(
6
):
421
5
.
[PubMed]
0268-3369
55.
Perfetti
P
,
Carlier
P
,
Strada
P
,
Gualandi
F
,
Occhini
D
,
Van Lint
MT
, et al.
Extracorporeal photopheresis for the treatment of steroid refractory acute GVHD
.
Bone Marrow Transplant
.
2008
Nov
;
42
(
9
):
609
17
.
[PubMed]
0268-3369
56.
González-Vicent
M
,
Ramírez
M
,
Pérez
A
,
Lassaletta
A
,
Sevilla
J
,
Díaz
MA
.
Extracorporeal photochemotherapy for steroid-refractory graft-versus-host disease in low-weight pediatric patients. Immunomodulatory effects and clinical outcome
.
Haematologica
.
2008
Aug
;
93
(
8
):
1278
80
.
[PubMed]
0390-6078
57.
Perotti
C
,
Del Fante
C
,
Tinelli
C
,
Viarengo
G
,
Scudeller
L
,
Zecca
M
, et al.
Extracorporeal photochemotherapy in graft-versus-host disease: a longitudinal study on factors influencing the response and survival in pediatric patients
.
Transfusion
.
2010
Jun
;
50
(
6
):
1359
69
.
[PubMed]
0041-1132
58.
Malagola
M
,
Cancelli
V
,
Skert
C
,
Leali
PF
,
Ferrari
E
,
Tiburzi
A
, et al.
Extracorporeal Photopheresis for Treatment of Acute and Chronic Graft Versus Host Disease: An Italian Multicentric Retrospective Analysis on 94 Patients on Behalf of the Gruppo Italiano Trapianto di Midollo Osseo
.
Transplantation
.
2016
Dec
;
100
(
12
):
e147
55
.
[PubMed]
0041-1337
59.
Niittyvuopio
R
,
Juvonen
E
,
Heiskanen
J
,
Lindström
V
,
Nihtinen
A
,
Sahlstedt
L
, et al.
Extracorporeal photopheresis in the treatment of acute graft-versus-host disease: a single-center experience
.
Transfusion
.
2018
Aug
;
58
(
8
):
1973
9
.
[PubMed]
0041-1132
60.
Cid
J
,
Carbassé
G
,
Suárez-Lledó
M
,
Moreno
DF
,
Martínez
C
,
Gutiérrez-García
G
, et al.
Efficacy and safety of one-day offline extracorporeal photopheresis schedule processing one total blood volume for treating patients with graft-versus-host disease
.
Transfusion
.
2019
Aug
;
59
(
8
):
2636
42
.
[PubMed]
0041-1132
61.
Greinix
HT
,
Volc-Platzer
B
,
Rabitsch
W
,
Gmeinhart
B
,
Guevara-Pineda
C
,
Kalhs
P
, et al.
Successful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease
.
Blood
.
1998
Nov
;
92
(
9
):
3098
104
.
[PubMed]
0006-4971
62.
Seaton
ED
,
Szydlo
RM
,
Kanfer
E
,
Apperley
JF
,
Russell-Jones
R
.
Influence of extracorporeal photopheresis on clinical and laboratory parameters in chronic graft-versus-host disease and analysis of predictors of response
.
Blood
.
2003
Aug
;
102
(
4
):
1217
23
.
[PubMed]
0006-4971
63.
Apisarnthanarax
N
,
Donato
M
,
Körbling
M
,
Couriel
D
,
Gajewski
J
,
Giralt
S
, et al.
Extracorporeal photopheresis therapy in the management of steroid-refractory or steroid-dependent cutaneous chronic graft-versus-host disease after allogeneic stem cell transplantation: feasibility and results
.
Bone Marrow Transplant
.
2003
Mar
;
31
(
6
):
459
65
.
[PubMed]
0268-3369
64.
Rubegni
P
,
Cuccia
A
,
Sbano
P
,
Cevenini
G
,
Carcagnì
MR
,
D’Ascenzo
G
, et al.
Role of extracorporeal photochemotherapy in patients with refractory chronic graft-versus-host disease
.
Br J Haematol
.
2005
Jul
;
130
(
2
):
271
5
.
[PubMed]
0007-1048
65.
Greinix
HT
,
Socié
G
,
Bacigalupo
A
,
Holler
E
,
Edinger
MG
,
Apperley
JF
, et al.
Assessing the potential role of photopheresis in hematopoietic stem cell transplant
.
Bone Marrow Transplant
.
2006
Aug
;
38
(
4
):
265
73
.
[PubMed]
0268-3369
66.
Couriel
DR
,
Hosing
C
,
Saliba
R
,
Shpall
EJ
,
Anderlini
P
,
Rhodes
B
, et al.
Extracorporeal photochemotherapy for the treatment of steroid-resistant chronic GVHD
.
Blood
.
2006
Apr
;
107
(
8
):
3074
80
.
[PubMed]
0006-4971
67.
Perseghin
P
,
Dassi
M
,
Balduzzi
A
,
Rovelli
A
,
Bonanomi
S
,
Uderzo
C
.
Mononuclear cell collection in patients undergoing extra-corporeal photo-chemotherapy for acute and chronic graft-vs.-host-disease (GvHD): comparison between COBE Spectra version 4.7 and 6.0 (AutoPBSC)
.
J Clin Apher
.
2002
;
17
(
2
):
65
71
.
[PubMed]
0733-2459
68.
Dignan
FL
,
Greenblatt
D
,
Cox
M
,
Cavenagh
J
,
Oakervee
H
,
Apperley
JF
, et al.
Efficacy of bimonthly extracorporeal photopheresis in refractory chronic mucocutaneous GVHD
.
Bone Marrow Transplant
.
2012
Jun
;
47
(
6
):
824
30
.
[PubMed]
0268-3369
69.
Del Fante
C
,
Scudeller
L
,
Viarengo
G
,
Bernasconi
P
,
Perotti
C
.
Response and survival of patients with chronic graft-versus-host disease treated by extracorporeal photochemotherapy: a retrospective study according to classical and National Institutes of Health classifications
.
Transfusion
.
2012
Sep
;
52
(
9
):
2007
15
.
[PubMed]
0041-1132
70.
Hautmann
AH
,
Wolff
D
,
Hahn
J
,
Edinger
M
,
Schirmer
N
,
Ammer
J
, et al.
Extracorporeal photopheresis in 62 patients with acute and chronic GVHD: results of treatment with the COBE Spectra System
.
Bone Marrow Transplant
.
2013
Mar
;
48
(
3
):
439
45
.
[PubMed]
0268-3369
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