Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the body. In the past decade, there has been a significant increase in knowledge of the sequelae of effects in preserved organs, and how dynamic intervention by perfusion can be used to mitigate injury and improve the quality of the donated organs. The present review focuses on (1) new information about the cell and molecular events impacting on ischemia/reperfusion injury during organ preservation, (2) strategies which use varied compositions and additives in organ preservation solutions to deal with these, (3) clear definitions of the developing protocols for dynamic organ perfusion preservation, (4) information on how the choice of perfusion solutions can impact on desired attributes of dynamic organ perfusion, and (5) summary and future horizons.

1.
Sayegh
MH
,
Carpenter
CB
.
Transplantation 50 years later—progress, challenges, and promises
.
N Engl J Med
.
2004
Dec
;
351
(
26
):
2761
6
.
[PubMed]
0028-4793
2.
Watson
CJ
,
Dark
JH
.
Organ transplantation: historical perspective and current practice
.
Br J Anaesth
.
2012
Jan
;
108
Suppl 1
:
i29
42
.
[PubMed]
0007-0912
3.
Marino
IR
,
Cirillo
C
.
An abridged photographic history of organ transplantation
.
Exp Clin Transplant
.
2014
Mar
;
12
Suppl 1
:
11
6
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24635784
[PubMed]
1304-0855
4.
Belzer
FO
,
Southard
JH
.
Principles of solid-organ preservation by cold storage
.
Transplantation
.
1988
Apr
;
45
(
4
):
673
6
.
[PubMed]
0041-1337
5.
Fuller
B
,
Guibert
E
,
Rodríguez
J
. Lessons from Natural Cold-Induced Dormancy to Organ Preservation in Medicine and Biotechnology: From the “Backwoods to the Bedside”. In:
Lubzens
E
,
Cerda
J
,
Clark
M
, editors
.
Dormancy and Resistance in Harsh Environments
.
Berlin, Heidelberg
:
Springer Berlin Heidelberg
;
2010
. pp.
253
78
.
6.
Brodie
TG
.
The perfusion of surviving organs
.
J Physiol
.
1903
Apr
;
29
(
3
):
266
75
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16992666
[PubMed]
0022-3751
7.
Locke
FS
,
Rosenheim
O
.
Contributions to the physiology of the isolated heart: the consumption of dextrose by mammalian cardiac muscle
.
J Physiol
.
1907
Dec
;
36
(
4-5
):
205
20
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16992904
[PubMed]
0022-3751
9.
Bickford
RG
,
Winton
FR
.
The influence of temperature on the isolated kidney of the dog
.
J Physiol
.
1937
Mar
;
89
(
2
):
198
219
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16994855
[PubMed]
0022-3751
10.
Calne
RY
,
Pegg
DE
,
Pryse-Davies
J
,
Brown
FL
.
Renal Preservation By Ice-Cooling: An Experimental Study Relating To Kidney Transplantation From Cadavers
.
BMJ
.
1963
Sep
;
2
(
5358
):
651
5
.
[PubMed]
0007-1447
11.
Pegg
DE
.
An approach to hypothermic renal preservation
.
Cryobiology
.
1978
Feb
;
15
(
1
):
1
17
.
[PubMed]
0011-2240
12.
Collins
GM
,
Bravo-Shugarman
M
,
Terasaki
PI
.
Kidney preservation for transportation. Initial perfusion and 30 hours’ ice storage
.
Lancet
.
1969
Dec
;
2
(
7632
):
1219
22
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/4187813
[PubMed]
0140-6736
13.
Humphries
AL
 Jr
,
Russell
R
,
Stoddard
LD
,
Moretz
WH
.
Successful five-day kidney preservation. Perfusion with hypothermic, diluted plasma
.
Invest Urol
.
1968
May
;
5
(
6
):
609
18
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/4914852
[PubMed]
0021-0005
14.
Humphries
AL
 Jr
,
Russell
R
,
Gregory
J
,
Carter
RH
,
Moretz
WH
.
Hypothermic perfusion of the canine kidney for 48 hours followed by reimplantation
.
Am Surg
.
1964
Nov
;
30
:
748
52
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14217114
[PubMed]
0003-1348
15.
Hobbs
KE
,
Hunt
AC
,
Palmer
DB
,
Badrick
FE
,
Morris
AM
,
Mitra
SK
, et al.
Hypothermic low flow liver perfusion as a means of porcine hepatic storage for six hours
.
Br J Surg
.
1968
Sep
;
55
(
9
):
696
703
.
[PubMed]
0007-1323
16.
Starzl
TE
,
Hakala
TR
,
Shaw
BW
 Jr
,
Hardesty
RL
,
Rosenthal
TJ
,
Griffith
BP
, et al.
A flexible procedure for multiple cadaveric organ procurement
.
Surg Gynecol Obstet
.
1984
Mar
;
158
(
3
):
223
30
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/6367113
[PubMed]
0039-6087
17.
Ross
H
,
Marshall
VC
,
Escott
ML
.
72-hr canine kidney preservation without continuous perfusion
.
Transplantation
.
1976
Jun
;
21
(
6
):
498
501
.
[PubMed]
0041-1337
18.
Belzer
FO
,
Glass
NR
,
Sollinger
HW
,
Hoffmann
RM
,
Southard
JH
.
A new perfusate for kidney preservation
.
Transplantation
.
1982
Mar
;
33
(
3
):
322
3
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7039039
[PubMed]
0041-1337
19.
Cameron
AM
,
Barandiaran Cornejo
JF
.
Organ preservation review: history of organ preservation
.
Curr Opin Organ Transplant
.
2015
Apr
;
20
(
2
):
146
51
.
[PubMed]
1087-2418
20.
Zimmerman
MA
,
Martin
A
,
Hong
JC
.
Basic considerations in organ perfusion physiology
.
Curr Opin Organ Transplant
.
2016
Jun
;
21
(
3
):
288
93
.
[PubMed]
1087-2418
21.
Ferng
AS
,
Schipper
D
,
Connell
AM
,
Marsh
KM
,
Knapp
S
,
Khalpey
Z
.
Novel vs clinical organ preservation solutions: improved cardiac mitochondrial protection
.
J Cardiothorac Surg
.
2017
Jan
;
12
(
1
):
7
.
[PubMed]
1749-8090
22.
van Golen
RF
,
Reiniers
MJ
,
Olthof
PB
,
van Gulik
TM
,
Heger
M
.
Sterile inflammation in hepatic ischemia/reperfusion injury: present concepts and potential therapeutics
.
J Gastroenterol Hepatol
.
2013
Mar
;
28
(
3
):
394
400
.
[PubMed]
0815-9319
23.
Land
WG
.
The Role of Postischemic Reperfusion Injury and Other Nonantigen-Dependent Inflammatory Pathways in Transplantation.
2005
. doi:.
24.
Olanders
K
,
Sun
Z
,
Börjesson
A
,
Dib
M
,
Andersson
E
,
Lasson
A
, et al.
The effect of intestinal ischemia and reperfusion injury on ICAM-1 expression, endothelial barrier function, neutrophil tissue influx, and protease inhibitor levels in rats
.
Shock
.
2002
Jul
;
18
(
1
):
86
92
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12095141
[PubMed]
1073-2322
25.
Post
S
,
Palma
P
,
Rentsch
M
,
Gonzalez
AP
,
Menger
MD
.
Differential impact of Carolina rinse and University of Wisconsin solutions on microcirculation, leukocyte adhesion, Kupffer cell activity and biliary excretion after liver transplantation
.
Hepatology
.
1993
Dec
;
18
(
6
):
1490
7
.
[PubMed]
0270-9139
26.
Vollmar
B
,
Glasz
J
,
Post
S
,
Menger
MD
.
Role of microcirculatory derangements in manifestation of portal triad cross-clamping-induced hepatic reperfusion injury
.
J Surg Res
.
1996
Jan
;
60
(
1
):
49
54
.
[PubMed]
0022-4804
27.
Biberthaler
P
,
Luchting
B
,
Massberg
S
,
Teupser
D
,
Langer
S
,
Leiderer
R
, et al.
Ischemia at 4 degrees C: a novel mouse model to investigate the effect of hypothermia on postischemic hepatic microcirculatory injury
.
Res Exp Med (Berl)
.
2001
Jan
;
200
(
2
):
93
105
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11271516
[PubMed]
0300-9130
28.
Schauer
RJ
,
Bilzer
M
,
Kalmuk
S
,
Gerbes
AL
,
Leiderer
R
,
Schildberg
FW
, et al.
Microcirculatory failure after rat liver transplantation is related to Kupffer cell-derived oxidant stress but not involved in early graft dysfunction
.
Transplantation
.
2001
Nov
;
72
(
10
):
1692
9
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11726835
[PubMed]
0041-1337
29.
Durand
MJ
,
Gutterman
DD
.
Diversity in mechanisms of endothelium-dependent vasodilation in health and disease
.
Microcirculation
.
2013
Apr
;
20
(
3
):
239
47
.
[PubMed]
1073-9688
30.
Nanobashvili
J
,
Neumayer
C
,
Fuegl
A
,
Blumer
R
,
Prager
M
,
Sporn
E
, et al.
Development of ‘no-reflow’ phenomenon in ischemia/reperfusion injury: failure of active vasomotility and not simply passive vasoconstriction
.
Eur Surg Res
.
2003
Sep-Oct
;
35
(
5
):
417
24
.
[PubMed]
0014-312X
31.
Olschewski
P
,
Hunold
G
,
Eipel
C
,
Neumann
U
,
Schö Ning
W
,
Schmitz
V
, et al.
Improved microcirculation by low-viscosity histidine-tryptophan-ketoglutarate graft flush and subsequent cold storage in University of Wisconsin solution: results of an orthotopic rat liver transplantation model.
doi:.
32.
Gao
WS
,
Takei
Y
,
Marzi
I
,
Lindert
KA
,
Caldwell-Kenkel
JC
,
Currin
RT
, et al.
Carolina rinse solution—a new strategy to increase survival time after orthotopic liver transplantation in the rat
.
Transplantation
.
1991
Sep
;
52
(
3
):
417
24
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1897011
[PubMed]
0041-1337
33.
Ballermann
BJ
,
Dardik
A
,
Eng
E
,
Liu
A
.
Shear stress and the endothelium
.
Kidney Int Suppl
.
1998
Sep
;
67
:
S100
8
.
[PubMed]
0098-6577
34.
Steinbauer
M
,
Harris
A
,
Hoffmann
T
,
Messmer
K
.
Pharmacological Effects of Dextrans on the Postischemic Leukocyte-Endothelial Interaction
.
Karger Publishers
;
1996
. pp.
114
25
.
35.
Corso
CO
,
Okamoto
S
,
Leiderer
R
,
Messmer
K
.
Resuscitation with hypertonic saline dextran reduces endothelial cell swelling and improves hepatic microvascular perfusion and function after hemorrhagic shock
.
J Surg Res
.
1998
Dec
;
80
(
2
):
210
20
.
[PubMed]
0022-4804
36.
Kawada
N
,
Tran-Thi
TA
,
Klein
H
,
Decker
K
.
The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus
.
Eur J Biochem
.
1993
Apr
;
213
(
2
):
815
23
.
[PubMed]
0014-2956
37.
Bełtowski
J
,
Jamroz-Wiśniewska
A
.
Hydrogen sulfide and endothelium-dependent vasorelaxation
.
Molecules
.
2014
Dec
;
19
(
12
):
21183
99
.
[PubMed]
1420-3049
38.
Jarnagin
WR
,
Rockey
DC
,
Koteliansky
VE
,
Wang
SS
,
Bissell
DM
.
Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis
.
J Cell Biol
.
1994
Dec
;
127
(
6
6 Pt 2
):
2037
48
.
[PubMed]
0021-9525
39.
Amersi
F
,
Shen
XD
,
Moore
C
,
Melinek
J
,
Busuttil
RW
,
Kupiec-Weglinski
JW
, et al.
Fibronectin-α 4 β 1 integrin-mediated blockade protects genetically fat Zucker rat livers from ischemia/reperfusion injury
.
Am J Pathol
.
2003
Apr
;
162
(
4
):
1229
39
.
[PubMed]
0002-9440
40.
Osborn
L
,
Vassallo
C
,
Browning
BG
,
Tizard
R
,
Haskard
DO
,
Benjamin
CD
, et al.
Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1)
.
J Cell Biol
.
1994
Feb
;
124
(
4
):
601
8
.
[PubMed]
0021-9525
41.
Wyllie
S
,
Barshes
NR
,
Gao
FQ
,
Karpen
SJ
,
Goss
JA
.
Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver
.
World J Gastroenterol
.
2008
Nov
;
14
(
44
):
6808
16
.
[PubMed]
1007-9327
42.
Wong
J
,
Johnston
B
,
Lee
SS
,
Bullard
DC
,
Smith
CW
,
Beaudet
AL
, et al.
A Minimal Role for Selectins in the Recruitment of Leukocytes into the Inflamed Liver Microvasculature.
1997
. https://dm5migu4zj3pb.cloudfront.net/manuscripts/119000/119468/JCI97119468.pdf. Accessed 10 Dec 2018.
43.
Jaeschke
H
,
Hasegawa
T
.
Role of neutrophils in acute inflammatory liver injury
.
Liver Int
.
2006
Oct
;
26
(
8
):
912
9
.
[PubMed]
1478-3223
44.
Trocha
SD
,
Kevil
CG
,
Mancini
MC
,
Alexander
JS
.
Organ preservation solutions increase endothelial permeability and promote loss of junctional proteins
.
Ann Surg
.
1999
Jul
;
230
(
1
):
105
13
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10400043
[PubMed]
0003-4932
45.
Wessel
F
,
Winderlich
M
,
Holm
M
,
Frye
M
,
Rivera-Galdos
R
,
Vockel
M
, et al.
Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin
.
Nat Immunol
.
2014
Mar
;
15
(
3
):
223
30
.
[PubMed]
1529-2908
46.
Worku
D
,
Laluf
S
,
McGee
J
,
Goswami
M
,
VanMeter
K
,
Slakey
DP
.
P-selectin expression in cold preserved kidneys in University of Wisconsin and histidine-tryptophan-ketoglutarate solutions
.
J Surg Res
.
2011
Jul
;
169
(
1
):
125
31
.
[PubMed]
0022-4804
47.
Land
WG
.
The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine
.
Sultan Qaboos Univ Med J
.
2015
May
;
15
(
2
):
e157
70
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26052447
[PubMed]
2075-051X
48.
Shen
XD
,
Ke
B
,
Zhai
Y
,
Gao
F
,
Tsuchihashi
S
,
Lassman
CR
, et al.
Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model
.
Liver Transpl
.
2007
Oct
;
13
(
10
):
1435
43
.
[PubMed]
1527-6465
49.
Wu
HS
,
Zhang
JX
,
Wang
L
,
Tian
Y
,
Wang
H
,
Rotstein
O
.
Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice
.
Hepatobiliary Pancreat Dis Int
.
2004
May
;
3
(
2
):
250
3
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15138120
[PubMed]
1499-3872
50.
Su
S
,
Wu
J
,
Gong
T
,
He
K
,
Feng
C
,
Zhang
M
, et al.
Inhibition of High Mobility Group Box 1-Toll-Like Receptor-4 Signaling by Glycyrrhizin Contributes to the Attenuation of Cold Ischemic Injury of Liver in a Rat Model
.
Transplant Proc
.
2016
Jan-Feb
;
48
(
1
):
191
8
.
[PubMed]
0041-1345
51.
Schaer
CA
,
Schoedon
G
,
Imhof
A
,
Kurrer
MO
,
Schaer
DJ
.
Constitutive Endocytosis of CD163 Mediates Hemoglobin-Heme Uptake and Determines the Noninflammatory and Protective Transcriptional Response of Macrophages to Hemoglobin.
2006
. doi:.
52.
Kristiansen
M
,
Graversen
JH
,
Jacobsen
C
,
Sonne
O
,
Hoffman
HJ
,
Law
SK
, et al.
Identification of the haemoglobin scavenger receptor
.
Nature
.
2001
Jan
;
409
(
6817
):
198
201
.
[PubMed]
0028-0836
53.
Ozaki
KS
,
Kimura
S
,
Murase
N
.
Use of carbon monoxide in minimizing ischemia/reperfusion injury in transplantation
.
Transplant Rev (Orlando)
.
2012
Apr
;
26
(
2
):
125
39
.
[PubMed]
0955-470X
54.
Gregory
SH
,
Wing
EJ
.
Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections
.
J Leukoc Biol
.
2002
Aug
;
72
(
2
):
239
48
.
[PubMed]
0741-5400
55.
Linehan
SA
,
Martínez-Pomares
L
,
Gordon
S
.
Macrophage lectins in host defence
.
Microbes Infect
.
2000
Mar
;
2
(
3
):
279
88
.
[PubMed]
1286-4579
56.
Sindram
D
,
Porte
RJ
,
Hoffman
MR
,
Bentley
RC
,
Clavien
PA
.
Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver
.
Gastroenterology
.
2000
Jan
;
118
(
1
):
183
91
.
[PubMed]
0016-5085
57.
Carestia
A
,
Kaufman
T
,
Schattner
M
.
Platelets: New Bricks in the Building of Neutrophil Extracellular Traps
.
Front Immunol
.
2016
Jul
;
7
:
271
.
[PubMed]
1664-3224
58.
Morrell
CN
,
Sun
H
,
Swaim
AM
,
Baldwin
WM
 3rd
.
Platelets an inflammatory force in transplantation
.
Am J Transplant
.
2007
Nov
;
7
(
11
):
2447
54
.
[PubMed]
1600-6135
59.
Vogel
S
,
Bodenstein
R
,
Chen
Q
,
Feil
S
,
Feil
R
,
Rheinlaender
J
, et al.
Platelet-derived HMGB1 is a critical mediator of thrombosis
.
J Clin Invest
.
2015
Dec
;
125
(
12
):
4638
54
.
[PubMed]
0021-9738
60.
Myronovych
A
,
Murata
S
,
Chiba
M
,
Matsuo
R
,
Ikeda
O
,
Watanabe
M
, et al.
Role of platelets on liver regeneration after 90% hepatectomy in mice
.
J Hepatol
.
2008
Sep
;
49
(
3
):
363
72
.
[PubMed]
0168-8278
61.
Kurokawa
T
,
Ohkohchi
N
.
Platelets in liver disease, cancer and regeneration
.
World J Gastroenterol
.
2017
May
;
23
(
18
):
3228
39
.
[PubMed]
1007-9327
62.
Nieswandt
B
,
Pleines
I
,
Bender
M
.
Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke.
Journal of Thrombosis and Haemostasis.
2011
;9 1 S:92–104. doi:.
63.
Förstermann
U
,
Li
H
.
Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling
.
Br J Pharmacol
.
2011
Sep
;
164
(
2
):
213
23
.
[PubMed]
0007-1188
64.
Schött
U
,
Solomon
C
,
Fries
D
,
Bentzer
P
.
The endothelial glycocalyx and its disruption, protection and regeneration: a narrative review
.
Scand J Trauma Resusc Emerg Med
.
2016
Apr
;
24
(
1
):
48
.
[PubMed]
1757-7241
65.
van Golen
RF
,
Reiniers
MJ
,
Vrisekoop
N
,
Zuurbier
CJ
,
Olthof
PB
,
van Rheenen
J
, et al.
The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury
.
Antioxid Redox Signal
.
2014
Sep
;
21
(
7
):
1098
118
.
[PubMed]
1523-0864
66.
Woodcock
TE
,
Woodcock
TM
.
Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy
.
Br J Anaesth
.
2012
Mar
;
108
(
3
):
384
94
.
[PubMed]
0007-0912
67.
Becker
BF
,
Jacob
M
,
Leipert
S
,
Salmon
AH
,
Chappell
D
.
Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases
.
Br J Clin Pharmacol
.
2015
Sep
;
80
(
3
):
389
402
.
[PubMed]
0306-5251
68.
Beijert
I
,
Mert
S
,
Huang
V
,
Karimian
N
,
Geerts
S
,
Hafiz
EO
, et al.
Endothelial Dysfunction in Steatotic Human Donor Livers: A Pilot Study of the Underlying Mechanism During Subnormothermic Machine Perfusion
.
Transplant Direct
.
2018
Apr
;
4
(
5
):
e345
.
[PubMed]
2373-8731
69.
Lopez
A
,
Panisello-Rosello
A
,
Castro-Benitez
C
,
Adam
R
,
Lopez
A
,
Panisello-Rosello
A
, et al.
Glycocalyx Preservation and NO Production in Fatty Livers-The Protective Role of High Molecular Polyethylene Glycol in Cold Ischemia Injury
.
Int J Mol Sci
.
2018
Aug
;
19
(
8
):
2375
.
[PubMed]
1661-6596
70.
Springer
TA
.
Adhesion receptors of the immune system
.
Nature
.
1990
Aug
;
346
(
6283
):
425
34
.
[PubMed]
0028-0836
71.
Chappell
D
,
Brettner
F
,
Doerfler
N
,
Jacob
M
,
Rehm
M
,
Bruegger
D
, et al.
Protection of glycocalyx decreases platelet adhesion after ischaemia/reperfusion: an animal study
.
Eur J Anaesthesiol
.
2014
Sep
;
31
(
9
):
474
81
.
[PubMed]
0265-0215
72.
Chappell
D
,
Dörfler
N
,
Jacob
M
,
Rehm
M
,
Welsch
U
,
Conzen
P
, et al.
Glycocalyx protection reduces leukocyte adhesion after ischemia/reperfusion
.
Shock
.
2010
Aug
;
34
(
2
):
133
9
.
[PubMed]
1073-2322
73.
McDonald
KK
,
Cooper
S
,
Danielzak
L
,
Leask
RL
.
Glycocalyx Degradation Induces a Proinflammatory Phenotype and Increased Leukocyte Adhesion in Cultured Endothelial Cells under Flow
.
PLoS One
.
2016
Dec
;
11
(
12
):
e0167576
.
[PubMed]
1932-6203
74.
Schmidt
EP
,
Yang
Y
,
Janssen
WJ
,
Gandjeva
A
,
Perez
MJ
,
Barthel
L
, et al.
The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis
.
Nat Med
.
2012
Aug
;
18
(
8
):
1217
23
.
[PubMed]
1078-8956
75.
Termeer
C
,
Benedix
F
,
Sleeman
J
,
Fieber
C
,
Voith
U
,
Ahrens
T
, et al.
Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
.
J Exp Med
.
2002
Jan
;
195
(
1
):
99
111
.
[PubMed]
0022-1007
76.
Schiefer
J
,
Lebherz-Eichinger
D
,
Erdoes
G
,
Berlakovich
G
,
Bacher
A
,
Krenn
CG
, et al.
Alterations of Endothelial Glycocalyx During Orthotopic Liver Transplantation in Patients With End-Stage Liver Disease
.
Transplantation
.
2015
Oct
;
99
(
10
):
2118
23
.
[PubMed]
0041-1337
77.
Murphy
LS
,
Wickersham
N
,
McNeil
JB
,
Shaver
CM
,
May
AK
,
Bastarache
JA
, et al.
Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction
.
Ann Intensive Care
.
2017
Oct
;
7
(
1
):
102
.
[PubMed]
2110-5820
78.
Johansson
PI
,
Stensballe
J
,
Rasmussen
LS
,
Ostrowski
SR
.
A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients
.
Ann Surg
.
2011
Aug
;
254
(
2
):
194
200
.
[PubMed]
0003-4932
79.
Fuller
B
,
Froghi
F
,
Davidson
B
.
Organ preservation solutions: linking pharmacology to survival for the donor organ pathway
.
Curr Opin Organ Transplant
.
2018
Jun
;
23
(
3
):
361
8
.
[PubMed]
1087-2418
80.
Guibert
EE
,
Petrenko
AY
,
Balaban
CL
,
Somov
AY
,
Rodriguez
JV
,
Fuller
BJ
.
Organ preservation: current concepts and new strategies for the next decade
.
Transfus Med Hemother
.
2011
;
38
(
2
):
125
42
.
[PubMed]
1660-3796
81.
Ali
F
,
Dua
A
,
Cronin
DC
.
Changing paradigms in organ preservation and resuscitation
.
Curr Opin Organ Transplant
.
2015
Apr
;
20
(
2
):
152
8
.
[PubMed]
1087-2418
82.
Peglow
S
,
Toledo
AH
,
Anaya-Prado
R
,
Lopez-Neblina
F
,
Toledo-Pereyra
LH
.
Allopurinol and xanthine oxidase inhibition in liver ischemia reperfusion
.
J Hepatobiliary Pancreat Sci
.
2011
Mar
;
18
(
2
):
137
46
.
[PubMed]
1868-6974
83.
Gaucher
C
,
Boudier
A
,
Bonetti
J
,
Clarot
I
,
Leroy
P
,
Parent
M
.
Glutathione: Antioxidant Properties Dedicated to Nanotechnologies
.
Antioxidants
.
2018
Apr
;
7
(
5
):
62
.
[PubMed]
2076-3921
84.
Nayak
BN
,
Buttar
HS
.
Evaluation of the antioxidant properties of tryptophan and its metabolites in in vitro assay
.
J Complement Integr Med
.
2016
Jun
;
13
(
2
):
129
36
.
[PubMed]
2194-6329
85.
Liu
JH
,
Chen
MM
,
Huang
JW
,
Wann
H
,
Ho
LK
,
Pan
WH
, et al.
Therapeutic effects and mechanisms of action of mannitol during H2O2-induced oxidative stress in human retinal pigment epithelium cells
.
J Ocul Pharmacol Ther
.
2010
Jun
;
26
(
3
):
249
57
.
[PubMed]
1080-7683
86.
Rauen
U
,
de Groot
H
.
New insights into the cellular and molecular mechanisms of cold storage injury
.
J Investig Med
.
2004
Jul
;
52
(
5
):
299
309
.
[PubMed]
1081-5589
87.
Radovits
T
,
Lin
LN
,
Zotkina
J
,
Koch
A
,
Rauen
U
,
Köhler
G
, et al.
Endothelial dysfunction after long-term cold storage in HTK organ preservation solutions: effects of iron chelators and N-α-acetyl-L-histidine
.
J Heart Lung Transplant
.
2008
Feb
;
27
(
2
):
208
16
.
[PubMed]
1053-2498
88.
Wille
T
,
Gonder
S
,
Thiermann
H
,
Seeger
T
,
Rauen
U
,
Worek
F
.
Evaluation of functional and structural alterations in muscle tissue after short-term cold storage in a new tissue preservation solution
.
Cells Tissues Organs
.
2011
;
194
(
6
):
501
9
.
[PubMed]
1422-6405
89.
Veres
G
,
Hegedűs
P
,
Barnucz
E
,
Schmidt
H
,
Radovits
T
,
Zöller
R
, et al.
TiProtec preserves endothelial function in a rat model
.
J Surg Res
.
2016
Jan
;
200
(
1
):
346
55
.
[PubMed]
0022-4804
90.
Pless-Petig
G
,
Walter
B
,
Bienholz
A
,
Rauen
U
.
Mitochondrial Impairment as a Key Factor for the Lack of Attachment after Cold Storage of Hepatocyte Suspensions
.
Cell Transplant
.
2017
Dec
;
26
(
12
):
1855
67
.
[PubMed]
0963-6897
91.
Plotnikov
EY
,
Silachev
DN
,
Jankauskas
SS
,
Rokitskaya
TI
,
Chupyrkina
AA
,
Pevzner
IB
, et al.
Mild uncoupling of respiration and phosphorylation as a mechanism providing nephro- and neuroprotective effects of penetrating cations of the SkQ family
.
Biochemistry (Mosc)
.
2012
Sep
;
77
(
9
):
1029
37
.
[PubMed]
0006-2979
92.
Petrenko
AY
,
Cherkashina
DV
,
Somov
AY
,
Tkacheva
EN
,
Semenchenko
OA
,
Lebedinsky
AS
, et al.
Reversible mitochondrial uncoupling in the cold phase during liver preservation/reperfusion reduces oxidative injury in the rat model
.
Cryobiology
.
2010
Jun
;
60
(
3
):
293
300
.
[PubMed]
0011-2240
93.
Zhang
ZW
,
Xu
XC
,
Liu
T
,
Yuan
S
.
Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases
.
Oxid Med Cell Longev
.
2016
;
2016
:
6859523
.
[PubMed]
1942-0900
94.
Skulachev
VP
,
Anisimov
VN
,
Antonenko
YN
,
Bakeeva
LE
,
Chernyak
BV
,
Erichev
VP
, et al.
An attempt to prevent senescence: a mitochondrial approach
.
Biochim Biophys Acta
.
2009
May
;
1787
(
5
):
437
61
.
[PubMed]
0006-3002
95.
Apostolova
N
,
Victor
VM
.
Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications
.
Antioxid Redox Signal
.
2015
Mar
;
22
(
8
):
686
729
.
[PubMed]
1523-0864
96.
Cherkashina
DV
,
Sosimchik
IA
,
Semenchenko
OA
,
Volina
VV
,
Petrenko
AY
.
Mitochondria-targeted plastoquinone derivative SkQ(1) decreases ischemia-reperfusion injury during liver hypothermic storage for transplantation
.
Biochemistry (Mosc)
.
2011
Sep
;
76
(
9
):
1022
9
.
[PubMed]
0006-2979
97.
Chen
C
,
Hou
J
.
Mesenchymal stem cell-based therapy in kidney transplantation
.
Stem Cell Res Ther
.
2016
Feb
;
7
(
1
):
16
.
[PubMed]
1757-6512
98.
Sun
Q
,
Huang
Z
,
Han
F
,
Zhao
M
,
Cao
R
,
Zhao
D
, et al.
Allogeneic mesenchymal stem cells as induction therapy are safe and feasible in renal allografts: pilot results of a multicenter randomized controlled trial
.
J Transl Med
.
2018
Mar
;
16
(
1
):
52
.
[PubMed]
1479-5876
99.
Torres Crigna
A
,
Daniele
C
,
Gamez
C
,
Medina Balbuena
S
,
Pastene
DO
,
Nardozi
D
, et al.
Stem/Stromal Cells for Treatment of Kidney Injuries With Focus on Preclinical Models
.
Front Med (Lausanne)
.
2018
Jun
;
5
:
179
.
[PubMed]
2296-858X
100.
Parekkadan
B
,
van Poll
D
,
Suganuma
K
,
Carter
EA
,
Berthiaume
F
,
Tilles
AW
, et al.
Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure
.
PLoS One
.
2007
Sep
;
2
(
9
):
e941
.
[PubMed]
1932-6203
101.
Fu
Y
,
Karbaat
L
,
Wu
L
,
Leijten
J
,
Both
SK
,
Karperien
M
.
Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration
.
Tissue Eng Part B Rev
.
2017
Dec
;
23
(
6
):
515
28
.
[PubMed]
1937-3368
102.
La Francesca
S
,
Ting
AE
,
Sakamoto
J
,
Rhudy
J
,
Bonenfant
NR
,
Borg
ZD
, et al.
Multipotent adult progenitor cells decrease cold ischemic injury in ex vivo perfused human lungs: an initial pilot and feasibility study
.
Transplant Res
.
2014
Nov
;
3
(
1
):
19
.
[PubMed]
2047-1440
103.
Waller
KR
,
Foley
JD
,
McAnulty
J
,
Murphy
CJ
.
Trophic Factor Supplementation Protects Kidney Tubule Cells from Cold Ischemic Injury and Decreases Free Radical Production during Rewarming
.
Cell Preserv Technol
.
2007
;
5
(
3
):
132
6
. 1538-344X
104.
Kwon
YS
,
Foley
JD
,
Russell
P
,
McAnulty
JF
,
Murphy
CJ
.
Prevention of cold ischemia/rewarming-induced ERK 1/2, p38 kinase and HO-1 activation by trophic factor supplementation of UW solution
.
Cryobiology
.
2008
Aug
;
57
(
1
):
72
4
.
[PubMed]
0011-2240
105.
McAnulty
JF
,
Reid
TW
,
Waller
KR
,
Murphy
CJ
.
Successful six-day kidney preservation using trophic factor supplemented media and simple cold storage
.
Am J Transplant
.
2002
Sep
;
2
(
8
):
712
8
.
[PubMed]
1600-6135
106.
Ambiru
S
,
Uryuhara
K
,
Talpe
S
,
Dehoux
JP
,
Jacobbi
L
,
Murphy
CJ
, et al.
Improved survival of orthotopic liver allograft in swine by addition of trophic factors to University of Wisconsin solution
.
Transplantation
.
2004
Jan
;
77
(
2
):
302
19
.
[PubMed]
0041-1337
107.
Cherkashina
DV
,
Petrenko
AY
.
Hepatoprotective effect of fetal tissue cytosol and its thermostable fraction in rats with carbon tetrachloride-induced hepatitis
.
Bull Exp Biol Med
.
2006
Apr
;
141
(
4
):
544
7
.
[PubMed]
0007-4888
108.
Ochenashko
OV
,
Nikitchenko
YV
,
Volkova
NA
,
Mazur
SP
,
Somov
AY
,
Fuller
BJ
, et al.
Functional hepatic recovery after xenotransplantation of cryopreserved fetal liver cells or soluble cell-factor administration in a cirrhotic rat model: are viable cells necessary?
J Gastroenterol Hepatol
.
2008
Jul
;
23
(
7 Pt 2
7pt2
):
e275
82
.
[PubMed]
0815-9319
109.
Cherkashina
DV
,
Tkacheva
EN
,
Somov
AY
,
Semenchenko
OA
,
Nardid
OA
,
Petrenko
AY
.
Capacity of bioregulators of stem and progenitor cells to strongly affect liver redox-dependent processes
.
Rejuvenation Res
.
2011
Dec
;
14
(
6
):
661
7
.
[PubMed]
1549-1684
110.
Cherkashina
DV
,
Semenchenko
OA
,
Grischuk
VP
,
Fuller
BJ
,
Petrenko
AY
.
Supplementation with Fetal-Specific Factors Ameliorates Oxidative Liver Damage During Hypothermic Storage and Reperfusion in a Rat Model.
2005
. www.liebertpub.com. Accessed 10 Dec 2018.
111.
Cherkashina
DV
,
Sosimchyk
IA
,
Semenchenko
OA
,
Semenchenko
AY
,
Volina
VV
,
Petrenko
AY
.
Bioregulators of stem and progenitor cells in preservation solution reduce cold ischemia-reperfusion injury of isolated rat livers
.
Biofactors
.
2016
May
;
42
(
3
):
287
95
.
[PubMed]
1872-8081
112.
Zaouali
MA
,
Padrissa-Altés
S
,
Ben Mosbah
I
,
Alfany-Fernandez
I
,
Massip-Salcedo
M
,
Casillas-Ramirez
A
, et al.
Improved rat steatotic and nonsteatotic liver preservation by the addition of epidermal growth factor and insulin-like growth factor-I to University of Wisconsin solution
.
Liver Transpl
.
2010
Sep
;
16
(
9
):
1098
111
.
[PubMed]
1527-6465
113.
Karangwa
SA
,
Dutkowski
P
,
Fontes
P
,
Friend
PJ
,
Guarrera
JV
,
Markmann
JF
, et al.
Machine Perfusion of Donor Livers for Transplantation: A Proposal for Standardized Nomenclature and Reporting Guidelines
.
Am J Transplant
.
2016
Oct
;
16
(
10
):
2932
42
.
[PubMed]
1600-6135
114.
Schlegel
A
,
Muller
X
,
Dutkowski
P
.
Hypothermic liver perfusion
.
Curr Opin Organ Transplant
.
2017
Dec
;
22
(
6
):
563
70
.
[PubMed]
1087-2418
115.
Burlage
LC
,
Karimian
N
,
Westerkamp
AC
,
Visser
N
,
Matton
AP
,
van Rijn
R
, et al.
Oxygenated hypothermic machine perfusion after static cold storage improves endothelial function of extended criteria donor livers
.
HPB (Oxford)
.
2017
Jun
;
19
(
6
):
538
46
.
[PubMed]
1365-182X
116.
Westerkamp
AC
,
Karimian
N
,
Matton
AP
,
Mahboub
P
,
van Rijn
R
,
Wiersema-Buist
J
, et al.
Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers
.
Transplantation
.
2016
Apr
;
100
(
4
):
825
35
.
[PubMed]
0041-1337
117.
Stegemann
J
,
Minor
T
.
Energy charge restoration, mitochondrial protection and reversal of preservation induced liver injury by hypothermic oxygenation prior to reperfusion
.
Cryobiology
.
2009
Jun
;
58
(
3
):
331
6
.
[PubMed]
0011-2240
118.
Minor
T
,
von Horn
C
,
Paul
A
.
Role of temperature in reconditioning and evaluation of cold preserved kidney and liver grafts
.
Curr Opin Organ Transplant
.
2017
Jun
;
22
(
3
):
267
73
.
[PubMed]
1087-2418
119.
Burra
P
,
Zanetto
A
,
Russo
FP
,
Germani
G
.
Organ Preservation in Liver Transplantation
.
Semin Liver Dis
.
2018
Aug
;
38
(
3
):
260
9
.
[PubMed]
0272-8087
120.
Guarrera
JV
,
Henry
SD
,
Samstein
B
,
Odeh-Ramadan
R
,
Kinkhabwala
M
,
Goldstein
MJ
, et al.
Hypothermic machine preservation in human liver transplantation: the first clinical series
.
Am J Transplant
.
2010
Feb
;
10
(
2
):
372
81
.
[PubMed]
1600-6135
121.
van Rijn
R
,
Karimian
N
,
Matton
AP
,
Burlage
LC
,
Westerkamp
AC
,
van den Berg
AP
, et al.
Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death
.
Br J Surg
.
2017
Jun
;
104
(
7
):
907
17
.
[PubMed]
0007-1323
122.
Clavien
P-A
,
Dutkowski
P
. Advances in Hypothermic Perfusion S52 | SUPPLEMENT CLAVIEN AND DUTKOWSKI.
2017
.
123.
Hessheimer
AJ
,
Fondevila
C
.
Liver perfusion devices: how close are we to widespread application?
Curr Opin Organ Transplant
.
2017
Apr
;
22
(
2
):
105
11
.
[PubMed]
1087-2418
124.
Bruinsma
BG
,
Yeh
H
,
Özer
S
,
Martins
PN
,
Farmer
A
,
Wu
W
, et al.
Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation
.
Am J Transplant
.
2014
Jun
;
14
(
6
):
1400
9
.
[PubMed]
1600-6135
125.
Selten
J
,
Schlegel
A
,
de Jonge
J
,
Dutkowski
P
.
Hypo- and normothermic perfusion of the liver: which way to go?
Best Pract Res Clin Gastroenterol
.
2017
Apr
;
31
(
2
):
171
9
.
[PubMed]
1521-6918
126.
Spetzler
VN
,
Goldaracena
N
,
Echiverri
J
,
Kaths
JM
,
Louis
KS
,
Adeyi
OA
, et al.
Subnormothermic ex vivo liver perfusion is a safe alternative to cold static storage for preserving standard criteria grafts
.
Liver Transpl
.
2016
Jan
;
22
(
1
):
111
9
.
[PubMed]
1527-6465
127.
Guarrera
JV
,
Estevez
J
,
Boykin
J
,
Boyce
R
,
Rashid
J
,
Sun
S
, et al.
Hypothermic machine perfusion of liver grafts for transplantation: technical development in human discard and miniature swine models
.
Transplant Proc
.
2005
Jan-Feb
;
37
(
1
):
323
5
.
[PubMed]
0041-1345
128.
Hoyer
DP
,
Mathé
Z
,
Gallinat
A
,
Canbay
AC
,
Treckmann
JW
,
Rauen
U
, et al.
Controlled Oxygenated Rewarming of Cold Stored Livers Prior to Transplantation: First Clinical Application of a New Concept
.
Transplantation
.
2016
Jan
;
100
(
1
):
147
52
.
[PubMed]
0041-1337
129.
Bruinsma
BG
,
Uygun
K
.
Subzero organ preservation: the dawn of a new ice age?
Curr Opin Organ Transplant
.
2017
Jun
;
22
(
3
):
281
6
.
[PubMed]
1087-2418
130.
Berendsen
TA
,
Bruinsma
BG
,
Puts
CF
,
Saeidi
N
,
Usta
OB
,
Uygun
BE
, et al.
Supercooling enables long-term transplantation survival following 4 days of liver preservation
.
Nat Med
.
2014
Jul
;
20
(
7
):
790
3
.
[PubMed]
1078-8956
131.
Fontes
P
,
Lopez
R
,
van der Plaats
A
,
Vodovotz
Y
,
Minervini
M
,
Scott
V
, et al.
Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions
.
Am J Transplant
.
2015
Feb
;
15
(
2
):
381
94
.
[PubMed]
1600-6135
132.
Laing
RW
,
Mergental
H
,
Mirza
DF
.
Normothermic ex-situ liver preservation: the new gold standard
.
Curr Opin Organ Transplant
.
2017
Jun
;
22
(
3
):
274
80
.
[PubMed]
1087-2418
133.
Liu
Q
,
Berendsen
T
,
Izamis
ML
,
Uygun
B
,
Yarmush
ML
,
Uygun
K
.
Perfusion defatting at subnormothermic temperatures in steatotic rat livers
.
Transplant Proc
.
2013
Nov
;
45
(
9
):
3209
13
.
[PubMed]
0041-1345
134.
Ravikumar
R
,
Jassem
W
,
Mergental
H
,
Heaton
N
,
Mirza
D
,
Perera
MT
, et al.
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
.
Am J Transplant
.
2016
Jun
;
16
(
6
):
1779
87
.
[PubMed]
1600-6135
135.
Liu
Q
,
Nassar
A
,
Buccini
L
,
Grady
P
,
Soliman
B
,
Hassan
A
, et al.
Ex situ 86-hour liver perfusion: pushing the boundary of organ preservation
.
Liver Transpl
.
2018
Apr
;
24
(
4
):
557
61
.
[PubMed]
1527-6465
136.
Nasralla
D
,
Coussios
CC
,
Mergental
H
,
Akhtar
MZ
,
Butler
AJ
,
Ceresa
CD
, et al.;
Consortium for Organ Preservation in Europe
.
A randomized trial of normothermic preservation in liver transplantation
.
Nature
.
2018
May
;
557
(
7703
):
50
6
.
[PubMed]
0028-0836
137.
Mergental
H
,
Perera
MT
,
Laing
RW
,
Muiesan
P
,
Isaac
JR
,
Smith
A
, et al.
Transplantation of Declined Liver Allografts Following Normothermic Ex-Situ Evaluation
.
Am J Transplant
.
2016
Nov
;
16
(
11
):
3235
45
.
[PubMed]
1600-6135
138.
Hosgood
SA
,
Nicholson
HF
,
Nicholson
ML
.
Oxygenated kidney preservation techniques
.
Transplantation
.
2012
Mar
;
93
(
5
):
455
9
.
[PubMed]
0041-1337
139.
Fuller
BJ
,
Attenburrow
VD
.
The effects of increasing the oncotic and osmotic pressure of the perfusate on bloodless hypothermic perfusion of liver in the rat
.
Cryobiology
.
1978
Oct
;
15
(
5
):
545
50
.
[PubMed]
0011-2240
140.
Fuller
BJ
,
Lee
CY
.
Hypothermic perfusion preservation: the future of organ preservation revisited?
Cryobiology
.
2007
Apr
;
54
(
2
):
129
45
.
[PubMed]
0011-2240
141.
Weisberg
HF
.
Osmotic pressure of the serum proteins
.
Ann Clin Lab Sci
.
1978
Mar-Apr
;
8
(
2
):
155
64
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/345945
[PubMed]
0091-7370
142.
Skillman
JJ
,
Parikh
BM
,
Tanenbaum
BJ
.
Pulmonary arteriovenous admixture. Improvement with albumin and diuresis
.
Am J Surg
.
1970
Apr
;
119
(
4
):
440
7
.
[PubMed]
0002-9610
143.
Skillman
JJ
.
The role of albumin and oncotically active fluids in shock
.
Crit Care Med
.
1976
Mar-Apr
;
4
(
2
):
55
61
.
[PubMed]
0090-3493
144.
Soto-Rivera
A
.
Relationship between protein osmotic pressure and density in plasma from cats, dogs, and humans
.
Proc Soc Exp Biol Med
.
1949
Jun
;
71
(
2
):
184
6
.
[PubMed]
0037-9727
145.
Carnevale
ME
,
Balaban
CL
,
Guibert
EE
,
Bottai
H
,
Rodríguez
JV
.
56. Evaluation of a new solution for hypothermic machine perfusion (HMP) of the liver. II – A study in the perfused rat liver in vitro
.
Cryobiology
.
2012
;
65
(
3
):
65
. 0011-2240
146.
Starling
EH
.
On the Absorption of Fluids from the Connective Tissue Spaces
.
J Physiol
.
1896
May
;
19
(
4
):
312
26
. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16992325
[PubMed]
0022-3751
147.
Carnevale
M.E.
,
Lausada
N.
,
Juan de Paz
L.
,
Stringa
P.
,
Rumbo
M.
,
Guibert
E.E.
,
Tiribelli
C.
,
Gondolesi
G.E.
RJV. Comparison of the novel preservation solution BGP-HMP vs HTK solution for static cold storage (SCS) of rat livers. Liver Transplant.
2018
;:Submitted for publication.
148.
’t Hart
NA
,
der van Plaats
A
,
Leuvenink
HG
,
van Goor
H
,
Wiersema-Buist
J
,
Verkerke
GJ
, et al.
Determination of an adequate perfusion pressure for continuous dual vessel hypothermic machine perfusion of the rat liver
.
Transpl Int
.
2007
Apr
;
20
(
4
):
343
52
.
[PubMed]
0934-0874
149.
Rodriguez
JV
,
Federico
MB
,
Pizarro
MD
,
Guibert
EE
,
Quintana
AB
,
Scandizzi
AL
.
A device to measure oxygen consumption during the hypothermic perfusion of the liver
.
Cryo Letters
.
2009
Sep-Oct
;
30
(
5
):
335
46
.
[PubMed]
0143-2044
150.
Llarrull
MS
,
Pizarro
MD
,
Scandizzi
AL
,
Bottai
H
,
Guibert
EE
,
Rodriguez
JV
.
Cold preservation of isolated hepatocytes in UW solution: experimental studies on the respiratory activity at 0 degrees C
.
Cryo Letters
.
2007
Sep-Oct
;
28
(
5
):
313
28
.
[PubMed]
0143-2044
151.
Pascucci
F
,
Carnevale
ME
,
Balaban
CL
,
Mamprin
ME
,
Guibert
EE
,
Rodríguez
JV
.
55. Evaluation of a new solution for hypothermic machine perfusion (HMP) of the liver. I – Composition and physicochemical parameters
.
Cryobiology
.
2012
;
65
(
3
):
357
. 0011-2240
152.
van der Plaats
A
,
’t Hart
NA
,
Morariu
AM
,
Verkerke
GJ
,
Leuvenink
HG
,
Ploeg
RJ
, et al.
Effect of University of Wisconsin organ-preservation solution on haemorheology
.
Transpl Int
.
2004
Jun
;
17
(
5
):
227
33
.
[PubMed]
0934-0874
153.
Tojimbara
T
,
Wicomb
WN
,
Garcia-Kennedy
R
,
Burns
W
,
Hayashi
M
,
Collins
G
, et al.
Liver transplantation from non-heart beating donors in rats: influence of viscosity and temperature of initial flushing solutions on graft function
.
Liver Transpl Surg
.
1997
Jan
;
3
(
1
):
39
45
.
[PubMed]
1074-3022
154.
Pappa
MD
,
Theodosiadis
NV
,
Paliouras
D
,
Rallis
T
,
Gogakos
AS
,
Barbetakis
N
, et al.
Advanced Perfusion Techniques - Flow versus Pressure
.
J Biomed (Syd)
.
2017
;
2
:
20
4
. 2207-0001
155.
Taylor
MJ
,
Baicu
SC
.
Current state of hypothermic machine perfusion preservation of organs: the clinical perspective
.
Cryobiology
.
2010
Jul
;
60
(
3
Suppl
):
S20
35
.
[PubMed]
0011-2240
156.
Downes
G
,
Hoffman
R
,
Huang
J
,
Belzer
FO
.
Mechanism of action of washout solutions for kidney preservation
.
Transplantation
.
1973
Jul
;
16
(
1
):
46
53
.
[PubMed]
0041-1337
157.
Vekemans
K
,
Liu
Q
,
Pirenne
J
,
Monbaliu
D
.
Artificial circulation of the liver: machine perfusion as a preservation method in liver transplantation
.
Anat Rec (Hoboken)
.
2008
Jun
;
291
(
6
):
735
40
.
[PubMed]
1932-8486
158.
Giwa
S
,
Lewis
JK
,
Alvarez
L
,
Langer
R
,
Roth
AE
,
Church
GM
, et al.
The promise of organ and tissue preservation to transform medicine
.
Nat Biotechnol
.
2017
Jun
;
35
(
6
):
530
42
.
[PubMed]
1087-0156
159.
Finger
EB
,
Bischof
JC
.
Cryopreservation by vitrification: a promising approach for transplant organ banking
.
Curr Opin Organ Transplant
.
2018
Jun
;
23
(
3
):
353
60
.
[PubMed]
1087-2418
160.
Bruinsma
BG
,
Berendsen
TA
,
Izamis
ML
,
Yeh
H
,
Yarmush
ML
,
Uygun
K
.
Supercooling preservation and transplantation of the rat liver
.
Nat Protoc
.
2015
Mar
;
10
(
3
):
484
94
.
[PubMed]
1754-2189
161.
Mandolino
C
,
Pizarro
MD
,
Quintana
AB
,
Rodríguez
JV
,
Mamprin
ME
.
Hypothermic preservation of rat liver microorgans (LMOs) in bes-gluconate solution. Protective effects of polyethyleneglycol (PEG) on total water content and functional viability
.
Ann Hepatol
.
2011
Apr-Jun
;
10
(
2
):
196
206
.
[PubMed]
1665-2681
162.
Carnevale
ME
,
Balaban
CL
,
Guibert
EE
,
Bottai
H
,
Rodriguez
JV
.
Hypothermic machine perfusion versus cold storage in the rescuing of livers from non-heart-beating donor rats
.
Artif Organs
.
2013
Nov
;
37
(
11
):
985
91
.
[PubMed]
0160-564X
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