Das Ausmaβ der Plättchenaggregation (PA) in vitro wird in Abbängigkeit von der Temperatur vor und während des Experiments untersucht. Die Messungen werden mit einer rheologischen Methode durchgeführt, wobei die PA durch Induktion einer definierten künstlichen Strömung spontan ausgelöst wird. Aggregationsfördernde Substanzen werden nicht verwendet. Bei 4° C und 37° C läβt sich keine, bzw. nur eine geringe PA auslösen, während bei Raumtem-peratur eine deutliche PA stattfindet. Dieses Ergebnis wird mit klinischen Befunden über Zahl und Überlebenszeit der transfundierten Plättchen verglichen und die Möglichkeit, das temperaturabhängige Aggregationsverhalten der Plättchen für die klinische Therapie nutzbar zu machen, diskutiert.

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