Elimination of ''Undesired Components'' by Automated Autotransfusion  Background: Usefulness and efficacy of automated autotransfusion in the process of recovering autologous, washed erythrocytes are well documented. The primary advantage compared to direct autotransfusion systems results from a more or less effective elimination of undesired components of wound and drainage blood. Material and Methods: The autotransfusion device Sequestra 1000( (Medtronic) was investigated. Assessed were haemoglobin (Hb), haematocrit (Hct), thrombocytes (PLT), free Hb (f-Hb), β-thromboglobulin (β-TG), elastase, lactate dehydrogenase (LDH), thrombin-antithrombin-III complex (TAT), plasmin-antiplasmin complex (PAP), fibrin degradation products (FDP) and the complement C3 in wound blood as well as in the autologous erythrocyte concentrate. Results: The wound blood showed, in comparison to normal as well as, low levels of Hb (6.2 mmol/l), Hct (0.28) and PLT (91 G/l), whereas indicators of cell decomposition (f-Hb:778 µmol/l, β-TG: >429 IU/ml and LDH: 98 µmol/l s–1) were increased. There was an increased concentration of Hb in the washed autologous erythrocyte concentrate, and undesired components were decreased. Conclusion: With automated autotransfusion, the plasmatic factors can be separated and removed. The quality of an automated system is demonstrated by the elimination rates of the purification process. The elimination rates showed a removal of undesired wound blood components greater than 80%.

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© 2001 S. Karger GmbH, Freiburg
2001
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