Autologous and allogeneic peripheral blood stem cell (PBSC) transplantations have achieved increasing importance in the treatment of hematologic malignancies and solid tumors during the past years. The establishment of efficient quality criteria for collection, processing, storage, and laboratory analysis of PBSC is of high clinical interest to assure a good proliferative capacity of stem cell transplants. Moreover, several guidelines and regulations require standardized and reproducible procedures for all aspects of stem cell transplantations. According to classical blood components, stem cell transplants are considered as defined therapeutic units with reproducible quality and efficacy. This article summarizes different quality criteria for the collection, processing, and laboratory analysis of peripheral blood progenitor cells and will examplary demonstrate a philosophy of a quality assurance system with regard on the stem cell transplantation viewed from a department of transfusion medicine.

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1999
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