Sporadische Berichte über Hepatitis-B- und NANB-Übertragungen durch intravenöse Immunglobuline (ivIg) und eine Serie von Hepatitis-NANB-Fällen nach Verabreichung von intramuskulärem Immunglobulin (imlg) zur Prophylaxe der Rhesus-(Rh-)Sensibilisierung (imlg-D) in der ehemaligen DDR veranlaβten uns, retrospektiv die Virussicherheit von imlg-D bezüglich transfusionsrelevanter Virusinfektionen zu untersuchen und zu dokumentieren. Bei 520 Rh-negativen Frauen, die in den Jahren von 1968 bis Anfang 1992 insgesamt 987mal der Rh-Prophylaxe mit imlg-D unterzogen worden waren, wurden die im Transfusionswesen vorgeschriebenen Infektionsparameter HBs-Ag, HIV-l,2-Ak, HCV-Ak sowie HBc-Ak und CMV-Ak bestimmt. Ein Vergleich der Befunde der Untersuchungsgruppe mit einer Kontrollgruppe Rh-positiver Frauen ergab keinen signifikanten Unterschied, was für die Virussicherheit der bei uns seit 24 Jahren verwendeten imlg-D spricht.

Keywords:
Immunglobulin, intramuskuläres, Immunglobulin, intravenöses, Rhesusprophylaxe, Virussicherheit
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© 1994 S. Karger AG, Basel
1994
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