In der vorliegenden Arbeit sind die Ergebnisse einer in-vitro-Testung des PL 100-Systems zur Entfernung kontaminierender Leukozyten aus Thrombozytenkonzentraten dargestellt. Die Leukozytenreduktion beträgt 99,7 ± 0,6% 25,7 ± 9,5 % der Thrombozyten werden im Filtersystem zurückgehalten. Die filtrierten Thrombozyten werden durch die Filtration nicht beeinfluβt; sowohl die plasmatischen Elektrolyt- und LDH-Konzentrationen als auch die Thrombozytenaggregationsfähigkeit und die Serotonin-Freisetzungsraten ändern sich nicht; auch die Ultrastruktur der Thrombozyten bleibt nach Filtration unverändert erhalten. Somit scheint trotz des hohen Thrombozytenverlustes das getestete Filtersystem eine geeignete Alternative zu den bisher verwendeten Methoden für die Herstellung Leukozyten-depletierter Thrombozytenkonzentrate darzustellen.

Keywords:
Leukozytendepletion, Thrombozytenkonzentrate
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© 1991 S. Karger AG, Basel
1991
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