Normovölämische Hämodilution unter normoxischen Bedingungen (arterieller Sauerstoff-Partialdruck normal) in Ruhe wird durch den kritischen arteriellen Sauerstoffgehalt von etwa 10 ml/dl entsprechend einer Hämoglobinkonzentration von 7,5 g/dl limitiert. Dieser kritische Sauerstoffgehalt leitet sich von der arteriovenösen Sauerstoffdifferenz des Myokards ab, wenn man unterstellt, daβ der koronare Blutfluβ um 33% ansteigt und der verfügbare Sauerstoff nahezu vollständig genutzt wird. Daneben scheint gelagertes Blut (Blutbeutel) wegen der Linksverschiebung der Sauerstoff-Gehaltskurve in Verbindung mit einer verminderten effektiven Hämoglobinkonzentration von eingeschränkter therapeutischer Wirkung zu sein.

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