Cryoprecipitates (CP) and cryodepleted plasma (CDP) were prepared from fresh frozen plasma (FFP). Plasma was easily and cleanly frozen at -50° C using a methanolbath Ultracryostat, which has been available commercially for the past few years. From a random sample (n = 6), factors VIIl·C, IX:C, V:C, fibrinogen, antithrombin III and fibronectin were determined. Concerning the total contents and the in-vitro-recovery of factor VIIL·C (x:104 IU/53.5%) and fibrinogen x:175mg/36.9%), the preparation method was as efficient as other equally common methods. Apart from the well-known applications, CP may be used for the substitution of fibronectin (x:46.2mg/73.0%). The supernatant plasma of cryoprecipitation (CDP) can be utilized for substitution of coagulation disorders especially deficiencies of the prothrombincomplex and antithrombin III (x:IX:C:183 IU/76.2%; V:C:140.5 U/73.8%; AT Ill:162 U/80.2%).

Keywords:
Cryoprecipitate, Cryodepleted plasma, Fresh frozen plasma, Fibronectin, Factor VIII
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© 1984 S. Karger AG, Basel
1984
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