Die renale Ausscheidung von 3-Methylhistidin bei Normalpersonen wird unter Normaldiät und bei fleischfreier Ernährung gemessen. Bei 8 Patienten im Postaggressionszustand ist 3-Methylhistidin sowie die Gesamtstickstoffausscheidung erhöht als Zeichen einer erhöhten Proteolyse unter Einbeziehung der Skelettmuskulatur. Bei 4 Insulinabhängigen Diabetikerinnen ist die 3-Methylhistidinaus-scheidung im Harn erhöht, wenn man sie auf kg/Körpergewicht bezieht. Der 3-Methylhistidin/Kreatinin-Quotient wird als zusätzlicher Parameter diskutiert. Die Gesamtstickstoffausscheidung ist hier ein besserer Parameter des Proteinabbaues als 3-Methylhistidin. Aus den Untersuchungen folgt, daβ die 3-Methylhistidinausscheidung im Harn ein geeigneter Parameter für die Beurteilung der Muskelproteolyse ist.

Keywords:
3-Methylhistidin, Stickstoffbilanz, Diabetes und Postaggressionszustand, Parenterale Ernährung
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© 1984 S. Karger AG, Basel
1984
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