A clear diminution in risks of transmitting overt hepatitis by blood transfusion has been achieved in New Jersey by implementation of a multifaceted program. Prescreening of blood donors for HBAg and interdiction of positive donors does not result in elimination of excess hazards of transfusion-associated hepatitis associated with the use of commercial blood. Units testing positive for HBAg are definitely associated with the hazard of transmission of HBV infection to previously susceptible recipients. Immune recipients display considerable protection when transfused with HBAg positive units, but the simultaneous administration of units containing high titers of HB antibody does not appear to confer protection. The consequences of administering units of AD or AY sub-types of HBAg to susceptible recipients are strikingly similar. Administration of a unit of blood containing HB antibody does not appear to be associated with an enhanced risk of HBV transmission.

Keywords:
Hepatitis B virus, Hepatitis B antigen, Blood transfusion, Transfusion-associated hepatitis
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© 1973 S. Karger AG, Basel
1973
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