... TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter...

...Kyoji Ogoshi; Yasumasa Kondoh; Tomoo Tajimi; Toshio Mitomi; Shigeru Harasawa; Norio Tani; Takeshi Miwa We investigated gastric acid secretion in 638 gastric cancer patients with respect to the association between aging and histologic types. In intestinal type tumors in which invasion is restricted...

... with gastric cancer. Both ACT and IAP levels generally increased according to the pTNM stage. Patients with both abnormal IAP and ACT levels showed a high risk of lymphatic and hepatic metastasis as well as peritoneal dissemination, with a resultant poor prognosis. Patients who had abnormal IAP levels...

... the G1/S transition of the cell cycle. To clarify the role of p 16 in primary gastric cancer, we have investigated somatic mutations of this gene by using the polymerase chain reaction/single strand conformation polymorphism (PCR-SSCP) method. In 23 surgical specimens of primary gastric cancer, none were...

...B. Klein; T. Klein; A. Nyska; J. Shapira; A. Figer; A. Schwartz; E. Rakovsky; E. Livni; H. Lurie The expression of HLA class I and II antigens was studied in 41 patients with gastric cancer and in 2 normal stomachs. The normal gastric epithelia were diffusely stained for class I antigens...

... 19.9 in 52% of patients with gastric cancer and in 63% with liver secondaries, and CEA in 95% of patients with colorectal cancer; whereas serum CA 125 above 65 U/ml was found in 25% of this subgroup, but only in those with already an elevated concentration of specific marker(s). Serum CEA or CA 19.9...

... representative reports were included in the pooled analysis. Frequently reported genome alterations were: the +3q27 and +8q24 mutations of TP53 for esophageal cancer; +20q13 for gastric cancer; –18q22 and +20q12–q13 mutations of APC , TP53 and KRAS for colorectal cancer, and the –18q22 mutation of KRAS and TP53...

...Chang Jae Kim; Jae Hwi Song; Yong Gu Cho; Zhang Cao; Su Young Kim; Suk Woo Nam; Jung Young Lee; Won Sang Park Helicobacter pylori increases the risk of gastric cancer development and triggers aberrant expression of activation-induced cytidine deaminase (AID). The goal of the present study...

...-associated antigens (TAAs) can elicit specific immune responses against tumors. Heparanase is overexpressed in gastric cancer, especially in invasive and metastatic cells, but is downregulated in differential normal tissue. Therefore, heparanase is a potential target in immunotherapy for patients...

...Mei Lan; Yongquan Shi; Li Sun; Lili Liu; Xueyan Guo; Yuanyuan Lu; Jun Wang; Jie Liang; Daiming Fan Background: Hypoxia-inducible factor 1α (HIF-1α) has been reported to be expressed aberrantly in gastric cancer cells. Stability and transactivation of HIF-1 were associated with the change...

... differentiated and poorly differentiated adenocarcinomas. On the other hand, the staining intensity of signet ring cell carcinoma was significantly weaker than that of the three adenocarcinoma groups. The high level of AFP-R expression in gastric cancers may allow the use of AFP-R as a new clinically useful...

...J. Liang; Y.L. Pan; X.X. Ning; L.J. Sun; M. Lan; L. Hong; J.P. Du; N. Liu; C.J. Liu; T.D. Qiao; D.M. Fan Cellular prion protein (PrP C ), a glycosylphosphatidylinositol-anchored membrane protein, was found in our lab to be widely expressed in gastric cancer cell lines. In order to evaluate its...

...Li Sun; Yongquan Shi; Changcun Guo; Liping Yao; Tao Lin; Jingping Du; Quanli Han; Ying Han; Daiming Fan Previously, a novel protein, MGr1-Ag, was associated with tumor multidrug resistance (MDR), and the role and the underlying mechanisms of MGr1-Ag in MDR of gastric cancer cells were characterized...

... and CXCR4 in gastric cancer, and their potential use as prognostic markers. The expressions of CCR7 and CXCR4 mRNA were analyzed by RT-PCR in 10 human gastric cancer cell lines and in 43 gastric cancer tissues, and in an additional 307 gastric cancer tissues by immunohistochemistry. Clinicopathological...

...Masahide Ikeguchi; Sachiko Matsumoto; Daiki Murakami; Shingo Kanaji; Shotaro Ohro; Yoshihiko Maeta; Shigeru Tatebe; Akira Kondo; Shun-ichi Tsujitani; Nobuaki Kaibara Peritoneal seeding is frequently detected in patients with gastric cancer. The peritoneal cavity is a compartment in which...

... in patients with resected gastric cancer. More recently, experimental models with cancer cell lines showed that chemosensitivity may be affected by the E-cadherin expression status. We investigated whether E-cadherin expression is correlated with the response to chemotherapy and the survival of patients...

...) , has been detected in a subset of colorectal cancers, suggesting SLC5A8 may also serve as a tumor suppressor. To further investigate the role of epigenetic inactivation of SLC5A8 expression in gastric cancer, we determined the methylation status of the SLC5A8 5′ CpG island (CGI) in a panel of gastric...

... gastric cancer susceptibility. Recently, a novel CDH1 germline variant presenting a G/A nucleotide change at cDNA position 2494 has been found in Japanese patients with familial diffuse gastric cancer. The consequent amino acid variation (Val/Met) may alter the binding activity to beta-catenin...

... to evaluate its biological significance in human gastric cancer, we investigated its expression in the stomach of a large series of patients (n = 193) by immunohistochemical staining with the monoclonal antibody Mac-2. Compared to normal tissues, primary gastric adenocarcinomas showed a slight increase...

...Koji Kono; Hiroshi Naganuma; Takayoshi Sekikawa; Hideki Amemiya; Akihiro Takahashi; Hidehiko Iizuka; Yoshiro Matsumoto Serum HER-2/neu (c-erbB-2) levels in patients with gastric cancer were evaluated by an enzyme-linked immunosorbent assay and tissue levels of HER-2/neu in the same cohort were...