... controls revealed significant differences in the expression levels of 49 genes. Gene ontology identified an association of significantly up-/downregulated genes to six functional classes, particularly genes involved in apoptosis control such as LGALS1, LGALS3, BAX, IL7R and TNFRSF25. In RCC patients...

...J.F. McEwan; M.L. Windsor; S.D. Cullis-Hill A putative role for prion protein (PrP) in apoptosis has been implicated. This function was investigated to test whether antibodies to PrP could induce apoptosis and be utilised in the treatment of cancers. Various antibodies to PrP were screened in MTT...

... demonstrate that the molecular profile mainly of BCL2 and BCL2L12 genes may serve as a new potential molecular biomarker predicting treatment response in gastric cancer cells. 9 09 2008 19 12 2008 11 5 2009 AGS cells BCL2 family bcl-2 Apoptosis BCL2L12 5-Fluorouracil...

...G. Basha; P. Yap; F. Penninckx The trypan blue exclusion test, the MTT test and an immuno-staining test for apoptosis were performed before and after incubation of SW620 human colonic carcinoma cells with different cytotoxic agents (CTAs) in order to assess tumor cell viability and CTA efficacy...

... to precede other signs of cell death for several hours. Typical morphological changes of apoptosis were observed after 4 h of exposure of cells to high AFP doses. Low concentrations of cAFP and eAFP (less than 0.1 mg/ml) failed to induce growth inhibition of HepG2 cells, rather showing a weak stimulative...

... to in the content or advertisements. Lung carcinoma nodules Lymphokine-activated killer cells Cocultures Proliferation Apoptosis Necrosis Tum orßiology Original Paper TumorBiol 1997;18:135-145 Received: April 10, 1996 Accepted after revision: October 10. 1996 M. Ghariba E. Tamboiseb A. Tamboiseb N...

...Nicholas Hawkins; Jacqueline Lees; Rebecca Hargrove; Terence O’Connor; Alan Meagher; Robyn Ward Purpose: Apoptosis is commonly observed in a variety of human tumors, and some of the genetic events which control this process have been identified in vitro. The aim of this study was to determine...

...Riikka Huovinen; Yrjö Collan The antiestrogen toremifene treatment results in regression or stabilization of dimethylbenz(a)anthracene(DMBA)-induced rat mammary tumors by reducing the mitotic activity and possibly by modifying the abundant spontaneous apoptosis seen in these tumors. A comparative...

..., Germany Key Words Renal cell carcinoma Mcl-1 Prognosis mRNA Apoptosis Abstract Background/Aims: Altered expression of the Bcl-2 family member Mcl-1 has been linked to the progression and outcome of various malignancies, but its expression and potential prognostic value has yet not been...

...V.H. Bermúdez-Morales; O. Peralta-Zaragoza; E. Guzmán-Olea; A. García-Carrancá; M. Bahena-Román; J.M. Alcocer-González; V. Madrid-Marina Objective: Our aims were to examine the ability of the human papillomaviruse (HPV) 16 E2 protein to induce apoptosis in a murine HPV-transformed cell line...

..., cell cycle, apoptosis and expression of cell-cycle- and apoptosis-regulatory genes were evaluated. Results: After treatment withc-myc AS[S]ODNs, the growth of cancer cells was markedly inhibited in a dose- and time-dependent manner and the levels of c-myc mRNA and protein were greatly decreased (p...

... cell numbers followed by application of the tetrazolium compound MTS. Immunoblot analysis was used to determine the NK-1 receptors and the DAPI method was applied to demonstrate apoptosis. Immunohistochemistry was used to demonstrate NK-1 receptors in primary human gastric and colon adenocarcinomas...

.... Methods: MS1 (a mouse endothelial cell line) was infected with an adenoviral vector ZD55-XAF1. Controls were uninfected or infected with ZD55-EGFP. Wound healing assay and tube formation assay were used to assess angiogenesis. Cell proliferation was detected by WST-1 assay, and apoptosis was detected...

...Carsten Kempkensteffen; Stefan Hinz; Hans Krause; Tobias Jäger; Jens Köllermann; Steffen Weikert; Frank Christoph; Martin Schostak; Kurt Miller; Mark Schrader The inhibitor of apoptosis family member livin is expressed in several neoplasms but is absent in most benign tissues. Livin has therefore...

.... Circulating CK-related polypeptides have commonly been used as tumor markers. While apoptosis is a mechanism of CK release, the molecular nature of circulating CKs is poorly understood. The aim is to clarify the dynamics of CK8 during apoptosis in vitro and the nature of circulating CK8 in patients with lung...

... was to determine the differential effects of the redox state and kinetics of nitrosative species on the key cancer processes of apoptosis. Therefore, a murine lung adenocarcinoma cell line was exposed to various NO X donor compounds differing in redox state and delivery kinetics. DNA strand breaks (DSBs) were...

... present in the circulation of cancer patients are released from apoptotic or necrotic tumour cells. CK18 is cleaved by caspases during apoptosis and a monoclonal antibody (M30) specific to caspase-cleaved forms is available. The molecular form of CK18 released from cells (caspase-cleaved or not) can...

... (AI) was determined by TdT-mediated dUTP nick end labeling assay. The correlation between EphA2 expression, pathologic grade, proliferation and apoptosis of astrocytic tumors was further analyzed. The results showed that 47.8% of cases expressed EphA2 mRNA and 43.3% of cases expressed EphA2 protein...

...Yan Bin Dong; Allison M. Phelps; Hai Liang Yang; Azemat Jamshidi-Parsian; Canming Chen; Hongying Hao; Jorge G. Gomez-Gutierrez; Heshan Sam Zhou; Kelly M. McMasters Objectives: In the present study, we investigate the role of apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein (MAP...

... induced apoptosis, through downregulating of survivin and activating of caspase cascades. Our results indicate that Ad-PTEN exerts its tumor suppressive effect on bladder cancer cells through inhibiting survivin and upregulating caspase-related proteins. Thus Ad-PTEN may be potentially therapeutic...