... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Gonad Homeobox Infertility Ovary Puberty...

... in Kallmann syndrome/normosomic central hypogonadotropic hypogonadism showed no abnormality. The patient presented with a pubertal course suggestive of a delayed puberty with gynecomastia, reduced growth rate, and infertility that need testosterone treatment to induce the appearance of the secondary sex...

... failure (POF) is a form of female infertility characterized by amenorrhea, hypoestrogenism, and elevated gonadotropin levels in women under the age of 40 years. Although several genes have been associated with POF, its causative genes remain to be identified. Here, we used whole-exome sequencing (WES...

...Faruk Hadziselimovic; Katharina Gegenschatz-Schmid; Gilvydas Verkauskas; Philippe Demougin; Vytautas Bilius; Darius Dasevicius; Michael B. Stadler The gonadotropin-releasing hormone agonist (GnRHa; Buserelin) rescues fertility during adulthood in the majority of high infertility risk cryptorchid...

... to in the content or advertisements. 2017 Infertility Malignant degeneration Mutation AMH AMHRII Cryptorchidism Male sex differentiation is driven by 2 distinct hormones [Jost, 1953], each produced by a separate cell compartment of the fetal testis. Testosterone produced by fetal Leydig cells...

... to determine a potential causative role of isolated congenital cryptorchidism in azoospermia and/or infertility in the context of our previously published GeneChip data. Cryptorchid patients, aged 7 months to 5 years and otherwise healthy, were enrolled in this prospective study. During surgery, testicular...

... strongly supports the theory that impaired mini-puberty is responsible for azoospermia and infertility in cryptorchidism. Molecular biological observations favor LH deficiency, with EGR4 as a master regulatory gene in Leydig cell dysgenesis, as the reason for impaired mini-puberty, and recent evidence...

..., 3 members of the DEAD-box RNA helicase family, and the GTSF1 gene were found to show significantly lower RNA signals in the high-infertility-risk group. In the immunohistochemical analysis, patients from the low-infertility-risk group showed coherently stronger staining for GTSF1 and PIWIL4 proteins...

... to isolated glandular hypospadias (table 1 ) [Lin and Achermann, 2008; Allali et al., 2011]. The link between NR5A1 and human female infertility came from the observation of familial cases with both 46,XY DSD and primary ovarian insufficiency (POI) [Lourenço et al., 2009]. POI is a common disorder...

...E. Dati; A. Valetto; V. Bertini; E. Chiocca; G.I. Baroncelli; R. Battini; S. Bertelloni 45,X maleness is a very rare disorder. We report on 2 new 45,X males aged 9 10/12 and 39 years, respectively. The boy presented for developmental delay, while the man was referred to us because of infertility...

.... Chromosome abnormality Endocrine disrupting chemical Exotic species Gonadal dysgenesis Intersex Infertility Wildlife Sexual development has been well studied in mammalian species and, as such, many of the determining factors are known compared to reptile, amphibian, fish, and bird species...

...H. Barasc; N. Mary; R. Letron; A. Calgaro; A.M. Dudez; N. Bonnet; Y. Lahbib-Mansais; M. Yerle; A. Ducos; A. Pinton Y-autosome translocations are rare in humans and pigs. In both species, these rearrangements can be responsible for meiotic arrest and subsequent infertility. Chromosome pairing...

...G. Forti; G. Corona; L. Vignozzi; C. Krausz; M. Maggi The prevalence of the Klinefelter’s syndrome, ranging between 1/500 and 1/1,000 in the general male population, rises up to 3–4% among infertile males and to 10–12% in azoospermic patients. Due to the paucity of symptoms, only 10% of Klinefelter...

...F. Hadziselimovic; N.O. Hadziselimovic; P. Demougin; G. Krey; B. Hoecht; E.J. Oakeley The purpose of early medical or surgical treatment of boys with undescended testes is to prevent the development of infertility. However, early and successful surgery cannot prevent infertility in cryptorchid boys...

...E. Marchina; L. Imperadori; M. Speziani; U. Omodei; S. Tombesi; S. Barlati This study analyses the prevalence of karyotype aberrations and Yq microdeletions in infertile couples undergoing intracytoplasmic sperm injection (ICSI). Before undergoing ICSI, each partner of 470 infertile couples...