... Hypogonadotropic hypogonadism Ovary Persistent Müllerian duct syndrome Sertoli cell Testis Uterus © 2021 S. Karger AG, Basel 2021 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any...

... in Kallmann syndrome/normosomic central hypogonadotropic hypogonadism showed no abnormality. The patient presented with a pubertal course suggestive of a delayed puberty with gynecomastia, reduced growth rate, and infertility that need testosterone treatment to induce the appearance of the secondary sex...

... Hypogonadotropic hypogonadism NR0B1 OCT3/4 Testis The atypical orphan nuclear receptor NR0B1 (OMIM 300473, previously called DAX1, dosage-sensitive sex-reversal adrenal hypoplasia critical region on the X-chromosome protein 1) is a critical regulator of adrenal and gonadal development, where...

..., and coloboma. Hypogonadotropic hypogonadism is a complex developmental disorder characterized by gonadotropin deficiency. Recently, a number of patients with SOX2 mutations have been shown to have hypogonadotropic hypogonadism, making SOX2 an interesting addition to the list of genes implicated in the etiology...

...J.-P. Hardelin; C. Dodé Kallmann syndrome (KS) combines hypogonadotropic hypogonadism and anosmia. Anosmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to gonadotropin-releasing hormone (GnRH) deficiency, which presumably results from a failure...