... determination and gonad development in mice, it has been reported that new non-transcriptional events, such as alternative splicing, could play a key role in sex determination in mammals. We know the role of key regulatory factors, like WT1(+/–KTS) or FGFR2(b/c) in pre-mRNA splicing and sex determination...

... to in the content or advertisements. 2020 Comparative genomics Development Evolution Gonad development Gonadal differentiation Oestradiol treatment Sex determination Disorders of sex development are common birth abnormalities in humans that affect 1.7% of live births [Fausto-Sterling, 2000...

... and lengths of exposure that influence TSD are remarkably variable among species. In addition, transitory gene regulatory networks leading to gonadal TSD have evolved. Although most genes involved in gonadal development are conserved in vertebrates, including TSD species, temporal and spatial gene expression...

...R. Jiménez; F.J. Barrionuevo; M. Burgos Gonads are the only organs with 2 possible developmental pathways, testis or ovary. A consequence of this unique feature is that mutations in genes controlling gonad development give rise not only to gonadal malformation or dysfunction but also to frequent...

... to in the content or advertisements. AMH Genital ridge Gonad development Rabbit Sex determination Sex differentiation SOX9 SRY Classical studies of Alfred Jost in rabbit fetuses [1947] established the still valid paradigm for sex differentiation in eutherian mammals. Basically Jost...

.... Gonad development Immunohistochemistry Mouse Sex determination SRY Sexual reproduction requires the existence of two sexes – male and female. In almost all mammals, the development of an individual into either a male or a female can be traced back to the bifurcation of a single developmental...

... of the Cres/testatin subgroup. The most likely candidate/s would be CstSC, CstTE-1/Cres3 or Cres as they are expressed in the fetal testicular tubules in early testis differentiation together with testatin. Cystatin type 2 family Gonad development Testatin knockout mouse Testis development...

... clinical cases of sexual ambiguities or through mouse transgenic/knockout studies. Most of these genes encode transcription factors (SRY, SOX9, WT1, SF-1, DAX1 and GATA4) or secreted factors (AMH , WNT4 , FGF9 and DHH) . To identify new candidate genes required for gonad development, a number...

... murine gonad development. A–F In situ hybridization was performed on whole mount gonads (g) and mesonephroi (m) at ( A ) 10.5 dpc, ( B ) 11.5 dpc, ( C ) 12.5 dpc, and ( D ) 13.5 dpc. Strong Bmp7 expression is observed in gonads of both sexes at 10.5 and 11.5 dpc ( A , B ). Bmp7 expression...