...Silke Altgilbers; Frank Rippke; Alexander Filbry; Stefanie Conzelmann; Jens-Peter Vietzke; Thorsten Burkhardt; Dörte Segger; Dennis Roggenkamp; Elke Grönniger Introduction: Xerosis cutis is characterized by a decreased stratum corneum (SC) hydration and an impaired skin barrier function. Urea...

...Hina Hussain; Jörg Ziegler; Gerd Hause; Johannes Wohlrab; Reinhard H.H. Neubert Background/Aims: Free amino acids (FAAs) and urea, present inside the corneocytes, can be important indicators of skin condition. However, due to the lack of a standard extraction protocol for FAAs from corneocytes...

... between them and their effects on the skin barrier in older people. This study aimed to compare the effect of a commercially available emollient containing 5% urea, ceramide NP and lactate (test emollient) to an alternative emollient without these additives (control emollient) on the properties...

...Aline Vieille-Petit; Nicholas Blickenstaff; Garrett Coman; Howard Maibach Background: Percutaneous penetration of urea in vivo in man has been documented. If urea can penetrate the skin, it may also move laterally. Lateral spreading of topical substances leads to unpredictable penetration dynamics...

... or psoriasis. To improve these symptoms, we investigated the efficacy of a new tonic containing the active ingredients urea, lactate, polidocanol, and Glycyrrhiza inflata root extract, containing licochalcone A. Study Design/Methods: 30 subjects with dry and itchy scalp conditions underwent a randomized half...

...Marie Lodén; Per Boström; Marianne Kneczke Salicylic acid (SA) and urea are widely used in topical preparations. Using a simple tape stripping technique the effect on the binding forces within the stratum corneum and the skin absorption of SA and urea were studied. The degree of stratum corneum...

... on both sides of the flap, one with normal blood flow and the other with a reproducible blood flow decrease (60%) obtained by ligation of one pedicle. 14 C-labelled compounds, progesterone (lipophilic), caffeine (amphiphilic) and urea (hydrophilic) were applied in ethanolic solution during 4 h on the two...

...F. Höche; T. Klapperstück; J. Wohlrab The complex metabolic function of L -ornithine has led to a great interest in studying its pharmacotherapeutic potential. L -Ornithine is known to be crucial for the metabolism of keratinocytes, especially in the synthesis of urea, polyamines and precursors...

...Natalia Kuzmina; Lena Hagströmer; Lennart Emtestam Urea has long been used to treat dry skin. In the present report, we compared two identical creams, with the exception that one contained both urea and sodium chloride and the other urea alone, in 23 healthy elderly subjects. Following a 2-week...

...Johannes Wohlrab; Christina Siemes; Wolfgang C. Marsch Topical preparations containing urea are firmly established in dermatological therapy and nursing care therapy. In addition, urea is frequently used as an inactive ingredient with disinfecting, keratoplastic and penetration-promoting action...

...M. Gloor; J. Fluhr; L. Lehmann; W. Gehring; R. Thieroff-Ekerdt Twenty subjects with healthy skin were treated with the following formulations for two weeks: drug-free W/O vehicle, 5% ammonium lactate (CAS 52003-58-4) in W/O vehicle, 5% urea (CAS 57-13-6) in W/O vehicle, 3% ammonium lactate + 3...

...Lena Hagströmer; Miruna Nyrén; Lennart Emtestam Urea has long been used to treat dry skin. In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis. Following a 2-week...

... xenobiotic interactions with corneocytes are assessed using reflectance colorimetry. It was used to evaluate comparatively the effects of ethanol and laurocapram at various dilutions. In addition, a 10% propylene-glycol-based gel supplemented with N-acetyl- L -cysteine, urea and salicylic acid in various...

... to in the content or advertisements. Stratum corneum reservoir Skin blanching Corticosteroid concentration Urea Chromametry Original Research Article Skin Pharmacol Appl Skin Physiol 1999;12:85 89 Received: Aug. 20, 1998 Accepted: Nov. 30, 1998 A Qualitative Estimate of the Influence of Halcinonide...