...Dongyun Lei; Li Ye; Si Wen; Junling Zhang; Litao Zhang; Mao-Qiang Man Background: The skin, particularly the epidermis, is subjected to various external stresses, including ultraviolet (UV) irradiation. UV irradiation, mainly UVB at wavelength of 280–315 nm, can alter several epidermal functions...

... in cytokine secretion induced by lipopolysaccharides (LPS) in a manner comparable with dexamethasone. In addition, topical application of SK-119 was able to block UVB-induced oxidative stress and attenuated caspase-mediated apoptosis, DNA adduct formation, and the concomitant cellular damage. Conclusion...

... complex (TNC) can protect from UVA1-induced (340–400 nm) and UVA- (320–400 nm)/UVB-induced (280–320 nm) upregulation of molecular markers associated with oxidative stress, inflammation, and ageing. Objectives: in the current double-blind, randomized, placebo-controlled multicenter study, we analyze...

...T. Mammone; E. Goyarts; P.E. Ya; M. Ingrassia; D. Gan; K. Marenus; D. Maes Treatment of normal human keratinocytes with UVC-irradiated rabbit globin mRNA 24 h before and after UVB exposure increased the survival of the human keratinocytes. We also observed that UVC-damaged mRNA reduced...

... developed for the treatment of cutaneous T-cell lymphoma and has recently been investigated in the treatment of psoriasis. In the present study the UV-modulating properties of bexarotene were evaluated by assessment of the minimal erythema dose (MED) for UVB light. In 11 patients participating in a phase II...

...Thomas Mammone; Michael Ingrassia; David Gan; Ken Marenus; Daniel Maes Ultraviolet irradiation of normal human keratinocytes induces a cytotoxic effect. The chromophore for this effect is believed to be genomic DNA. However, DNA damage is known to be repaired in UVB irradiated keratinocytes...

... with a UVB-activated pseudocatalase can successfully remove epidermal H 2 O 2 in vitiligo. This approach leads to recovery of the oxidative damage in the epidermis and remarkable repigmentation in this disorder. 1999 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...