... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cytokines Stratum corneum...

...Mirjam J. Schaap; Finola M. Bruins; Xuehui He; Kadri Orro; Malou Peppelman; Piet E. J. van Erp; Elke M. G. J. de Jong; Hans J. P. M. Koenen; Ellen H. van den Bogaard; Marieke M. B. Seyger Introduction: Transdermal analysis patches (TAPs) noninvasively measure soluble proteins in the stratum corneum...

...Ana S. Évora; Michael J. Adams; Simon A. Johnson; Zhibing Zhang Background: Skin is the interface between an organism and the external environment, and hence the stratum corneum (SC) is the first to withstand mechanical insults that, in certain conditions, may lead to integrity loss...

... dermatitis Organ culture Skin barrier Skin physiology/structure Stratum corneum Research Article Skin Pharmacol Physiol 2021;34:8 18 DOI: 10.1159/000513055 Received: July 7, 2020 Accepted: November 13, 2020 Published online: February 18, 2021 A Novel Multi-Action Emollient Plus Cream Improves Skin...

...Philip W. Wertz Cornified cells of the stratum corneum have a monolayer of an unusual lipid covalently attached to the outer surface. This is referred to as the corneocyte lipid envelope (CLE). It consists of a monolayer of ω-hydroxyceramides covalently attached to the outer surface...

...Jacob R. Bow; Yoshihiko Sonoki; Masayuki Uchiyama; Eri Shimizu; Kousei Tanaka; Reinhold H. Dauskardt Background: The lipid components and natural moisturizing factors (NMFs) of the stratum corneum (SC) are integral pieces of the self-regulating barrier strategy which comprises one of the most...

...Thomas Schmitt; Reinhard H.H. Neubert This review is the second part of a series which presents the state of the art in stratum corneum (SC) lipid matrix (LM) research in depth. In this part, the various hypothetical models which were developed to describe the structure and function of the SC LM...

...So Hyun Yoon; Jong Il Park; Ji Eun Lee; Cheol Hwan Myung; Jae Sung Hwang Background/Objectives: Ultraviolet (UV) radiation damages the stratum corneum (SC) and disrupts the skin barrier. The damaged skin changes in the molecular composition of the SC, including its water content. However...

...Ann-Christin Foerster; Reinhard H.H. Neubert The main barrier of the human skin is the stratum corneum (SC). Its properties (also depending on the health and age of the individual) and its influence on improved penetration of active ingredients into the skin are the subject of many research...

... thickness (ET). So far, the illustration of the stratum corneum (SC) has not been possible without artifacts. Objective: Precision in vivo measurement of the ET and SC, duly considering the impact of location on the body, age, and gender. Methods: In this pilot study on 20 skin-healthy subjects aged 18–66...

...Johannes Wohlrab; Alexander Gabel; Martin Wolfram; Ivo Grosse; Reinhard H.H. Neubert; Sophie C. Steinbach Of particular importance for Stratum corneum (SC) lipids are the free fatty acids (FFAs). Age-related changes of the SC structure lead to diminished capacity for barrier compensation. The aims...

...Efrem N. Tessema; Tsige Gebre-Mariam; Reinhard H.H. Neubert; Johannes Wohlrab The outer most layer of the skin, the stratum corneum, consists of corneocytes which are coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure. It is responsible for the skin barrier...

... frequently report SS. Methods: Subjects with SS ( n = 29), NSS ( n = 30), AD ( n = 11), and AR ( n = 27) were included. Stratum corneum (SC) thickness, water, ceramides/fatty acids, and natural moisturizing factor (NMF) were measured by CRS along with transepidermal water loss and capacitance on the ventral...

... of lipids and enzymes in the skin barrier. This slows down reorganisation of the lipid lamellae in the stratum corneum (SC). Methods: Skin barrier integrity was measured by morphometric analysis of the lipid lamellae in the SC after 4 weeks of treatment with a foam cream (active agent vs. placebo). Results...

...Russel M. Walters; Preeya Khanna; Melissa Chu; M. Catherine Mack The structure of the stratum corneum (SC) and the corresponding skin barrier develops from before birth up to about 4 years of age. Large subject-to-subject variability within an age group requires a large population to observe trends...

... evaluation of the skin. The aim of this study is to gather information about inter- and intra-individual variations in the spectral descriptors of water content and structure, organization of the lipid barrier and structure of proteins in the stratum corneum (SC). Methods: In vivo SC measurements were...

... surfactant, and transferosomes (ultraflexible vesicles) showed significantly greater penetration into the skin and permeation across the stratum corneum. Significant enhancement of caffeine penetration into hair follicles was found for transferosomes and those liposomes containing oleic acid. Conclusions: We...

... obtained using methods 1, 2 and 4 show that the investigated oils do not penetrate deeper than 11 µm into human and porcine skin. Petrolatum has a prominent swelling effect on the stratum corneum (32% in vivo, 28% ex vivo), while the other oils exhibit no significant swelling effect. By using method 3...

...Denise Falcone; Natallia E. Uzunbajakava; Babu Varghese; Gabriela Ricardo de Aquino Santos; Renée J.H. Richters; Peter C.M. van de Kerkhof; Piet E.J. van Erp Skin barrier function, confined to the stratum corneum, is traditionally evaluated using established, noninvasive biophysical methods like...

... D content change in the stratum corneum (SC) and the repairing role of cathepsin D in chronic photodamaged skin barrier via the application of cathepsin D gel. Methods: Cathepsin D gel (0.001%) was applied to chronic photodamaged (sun-exposed forearm) human skin on identical sites (1 cm²/area) twice...