.... An experimental lateral MD setup was used to determine the influence of percutaneous skin penetration characteristics of an active ingredient with different lipophilic and hydrophilic characteristics. Therefore, hydrophilic caffeine and lipophilic LIP1, which have an identical molecular weight but different...

... Background: The chronicity of psoriasis often requires continuous topical treatment. Materials and Methods: Here, the radical protection of a cream containing various herbal oils was evaluated in vivo by electron paramagnetic resonance (EPR) spectroscopy and its skin penetration by Raman microscopy in intact...

... ingredients is governed by their release into the underlying epidermal and dermal tissue, especially when administered topically. Objective: The aim of this study was to understand if different physicochemical properties influence the skin penetration of active ingredients and the depth to which...

... penetration Skin penetration Laser scanning microscopy Caffeine The skin is the physical barrier to our environment [ 1 ] and accounts for approximately 16% of the human body weight, with a surface area of around 2 m 2 in human adults [ 2 ]. Due to its strong barrier properties, the skin...

...Christofori M.R.R. Nastiti; Yousuf Mohammed; Krishna C. Telaprolu; Xiaowen Liang; Jeffrey E. Grice; Michael S. Roberts; Heather A.E. Benson Background: Pig skin is a widely acknowledged surrogate for human skin for in vitro/ex vivo skin penetration studies with application for small molecules...

... Toxicity Skin penetration Fluorescence lifetime imaging microscopy Sun protector factor Multi-photon tomography In recent years, the study of materials with nanometre dimensions has attracted great interest [ 1 ]. Due to their size, these materials exhibit distinct physicochemical and optical...

..., instructions or products referred to in the content or advertisements. Antifungal activity Clotrimazole Microemulsion Microemulsion-based gel Skin penetration Skin retention Original Paper Skin Pharmacol Physiol 2018;31:292 297 DOI: 10.1159/000491756 Received: March 3, 2018 Accepted after...

... profiling Skin penetration Confocal Raman microspectroscopy (CRM) is increasingly used to determine penetration profiles of xenobiotics in the skin due to the fact that it is a non-destructive method and only minimal sample preparation is needed [ 1,2,3,4,5,6,7,8,9,10,11,12 ]. Furthermore, it can...

... by the addition of penetration enhancers may facilitate the passage of drugs through the stratum corneum. Methods: In this paper, the skin penetration effect of phytosphingosine and 9 derived phytoceramides (PCERs) on 3 transdermal model drugs (i.e. caffeine, testosterone, ibuprofen) was investigated via Franz...

... release Hydrogels Lipid-core nanocapsules Mometasone furoate Skin permeability Skin penetration Determination of Drug Content The MF assay in hydrogels was carried out by HPLC after extraction of drug in methanol, according to a previously validated method [ 25 ]. Then, 1 g...

..., instructions or products referred to in the content or advertisements. Arjunolic acid Triterpenes Antiaging properties Skin blood microcirculation Skin penetration Skin aging represents a highly complex but not yet fully understood progressive, multifaceted process [ 1 ]. It is currently...

... Skin penetration Predicting percutaneous absorption Less than a year after joining the faculty at the University of California at San Francisco in 1980, a senior colleague, and world-renowned pharmacokineticist, Sidney Riegelman, was lost to the pharmaceutical sciences while scuba diving...

..., instructions or products referred to in the content or advertisements. Dermal drug delivery Nonivamide Pig ear skin Skin penetration Skin permeation Chronic itch is a widespread disease amongst the working population. In many cases, itching is a symptom of other diseases such as atopic...

.... Microemulsion Peptide Penetration enhancer Skin penetration 1,2-pentylene glycol Carnosine Since the skin is the largest organ of the human body it is an important target site for the application of drugs. However, in order to reach therapeutic drug concentrations, the uppermost barrier...

... microdialysis Probe depth Skin penetration Topical drug administration Benzoic acid Ex vivo study Original Paper Skin Pharmacol Physiol 2012;25:9 16 DOI: 10.1159/000330491 Received: November 25, 2010 Accepted after revision: May 9, 2011 Published online: August 17, 2011 Probe Depth Matters in Dermal...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Skin penetration Cinnamaldehyde Penetration enhancers Local lymph node assay Ethanol Aqueous ethanol Propylene glycol...

... molecular size, skin penetration of HA may be limited. Recent studies have demonstrated that low-molecular-weight HA (LMW HA) may show a certain proinflammatory activity. We thus aimed to characterize an LMW-sized HA molecule that combines strong anti-aging abilities with efficient skin penetration...

...-particle interaction, drug release and skin penetration were investigated including a conventional oil-in-water cream for reference. Both with SLN and cream, PD release was clearly superior to PC release which exceeded BMV release. With the cream, the rank order did not change when studying skin...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Microdialysis Skin penetration Skin barrier Bioavailability Bioequivalence Drug delivery, topical Review Skin...

...S.E. dal Belo; L.R. Gaspar; P.M.B.G. Maia Campos; J.-P. Marty Green tea (Camellia sinensis) and Ginkgo biloba extracts in cosmetic formulations have been suggested to protect the skin against UV-induced damage and skin ageing. Thus, it is very important to assess the human skin penetration...