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Keywords: Skin penetrationClose
Skin Pharmacol Physiol (2022) 35 (4): 235–246.
Published Online: 16 February 2022
.... An experimental lateral MD setup was used to determine the influence of percutaneous skin penetration characteristics of an active ingredient with different lipophilic and hydrophilic characteristics. Therefore, hydrophilic caffeine and lipophilic LIP1, which have an identical molecular weight but different...
Juergen Lademann, Parvin Mansouri, Ali Nahavandi, Axel Ahlers, Fatemeh Zibakalam-Mofrad, Barbara Brower, Maryam Nahavandi, Frank Feddern, Maxim E. Darvin, Sabine Schanzer, Heike Richter, Martina C. Meinke, Seyed Ahmad Rezaii, Masoumeh Rohaninasab, Susan Farshi, Massimo Iacobelli, Sora Jung
Skin Pharmacol Physiol (2021) 34 (6): 337–350.
Published Online: 17 August 2021
... Background: The chronicity of psoriasis often requires continuous topical treatment. Materials and Methods: Here, the radical protection of a cream containing various herbal oils was evaluated in vivo by electron paramagnetic resonance (EPR) spectroscopy and its skin penetration by Raman microscopy in intact...
Skin Pharmacol Physiol (2021) 34 (4): 203–213.
Published Online: 21 May 2021
... ingredients is governed by their release into the underlying epidermal and dermal tissue, especially when administered topically. Objective: The aim of this study was to understand if different physicochemical properties influence the skin penetration of active ingredients and the depth to which...
Anna Lena Klein, Markus Lubda, Paniz Akbarzadeh Taghavi, Jürgen Lademann, Ingeborg Beckers, Jörg von Hagen, Harald Kolmar, Alexa Patzelt
Skin Pharmacol Physiol (2020) 33 (2): 117–126.
Published Online: 11 February 2020
... penetration Skin penetration Laser scanning microscopy Caffeine The skin is the physical barrier to our environment [ 1 ] and accounts for approximately 16% of the human body weight, with a surface area of around 2 m 2 in human adults [ 2 ]. Due to its strong barrier properties, the skin...
Christofori M.R.R. Nastiti, Yousuf Mohammed, Krishna C. Telaprolu, Xiaowen Liang, Jeffrey E. Grice, Michael S. Roberts, Heather A.E. Benson
Skin Pharmacol Physiol (2019) 32 (4): 182–191.
Published Online: 14 May 2019
...Christofori M.R.R. Nastiti; Yousuf Mohammed; Krishna C. Telaprolu; Xiaowen Liang; Jeffrey E. Grice; Michael S. Roberts; Heather A.E. Benson Background: Pig skin is a widely acknowledged surrogate for human skin for in vitro/ex vivo skin penetration studies with application for small molecules...
Camila O. Vieira, Jeffrey E. Grice, Michael S. Roberts, Isha N. Haridass, Marcelo Dutra Duque, Patrícia S. Lopes, Vânia R. Leite-Silva, Tereza S. Martins
Skin Pharmacol Physiol (2018) 32 (1): 32–42.
Published Online: 31 October 2018
... Toxicity Skin penetration Fluorescence lifetime imaging microscopy Sun protector factor Multi-photon tomography In recent years, the study of materials with nanometre dimensions has attracted great interest [ 1 ]. Due to their size, these materials exhibit distinct physicochemical and optical...
Skin Pharmacol Physiol (2018) 31 (6): 292–297.
Published Online: 21 August 2018
..., instructions or products referred to in the content or advertisements. Antifungal activity Clotrimazole Microemulsion Microemulsion-based gel Skin penetration Skin retention Original Paper Skin Pharmacol Physiol 2018;31:292 297 DOI: 10.1159/000491756 Received: March 3, 2018 Accepted after...
Skin Pharmacol Physiol (2016) 29 (2): 92–101.
Published Online: 08 April 2016
... profiling Skin penetration Confocal Raman microspectroscopy (CRM) is increasingly used to determine penetration profiles of xenobiotics in the skin due to the fact that it is a non-destructive method and only minimal sample preparation is needed [ 1,2,3,4,5,6,7,8,9,10,11,12 ]. Furthermore, it can...
Lieselotte Veryser, Jente Boonen, Lien Taevernier, Joren Guillaume, Martijn Risseeuw, Syed Nisar Hussain Shah, Nathalie Roche, Serge Van Calenbergh, Bart De Spiegeleer
Skin Pharmacol Physiol (2015) 28 (3): 124–136.
Published Online: 16 December 2014
... by the addition of penetration enhancers may facilitate the passage of drugs through the stratum corneum. Methods: In this paper, the skin penetration effect of phytosphingosine and 9 derived phytoceramides (PCERs) on 3 transdermal model drugs (i.e. caffeine, testosterone, ibuprofen) was investigated via Franz...
Ana Melero, Aline Ferreira Ourique, Silvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Claus-Michael Lehr, Ruy Carlos Ruver Beck, Ulrich Schaefer
Skin Pharmacol Physiol (2014) 27 (4): 217.
Published Online: 17 April 2014
... to in the content or advertisements. Drug release Hydrogels Lipid-core nanocapsules Mometasone furoate Skin permeability Skin penetration Polymeric nanoparticles are defined as submicrometric colloidal particles [ 1 ]. These particles are drug carrier systems that have been extensively studied...
M. Farwick, T. Köhler, J. Schild, M. Mentel, U. Maczkiewitz, V. Pagani, A. Bonfigli, L. Rigano, D. Bureik, G.G. Gauglitz
Skin Pharmacol Physiol (2014) 27 (2): 71–81.
Published Online: 05 September 2013
..., instructions or products referred to in the content or advertisements. Arjunolic acid Triterpenes Antiaging properties Skin blood microcirculation Skin penetration Skin aging represents a highly complex but not yet fully understood progressive, multifaceted process [ 1 ]. It is currently...
Skin Pharmacol Physiol (2013) 26 (4-6): 181–189.
Published Online: 29 July 2013
... Skin penetration Predicting percutaneous absorption Less than a year after joining the faculty at the University of California at San Francisco in 1980, a senior colleague, and world-renowned pharmacokineticist, Sidney Riegelman, was lost to the pharmaceutical sciences while scuba diving...
Skin Pharmacol Physiol (2013) 26 (3): 139–146.
Published Online: 21 March 2013
... Pig ear skin Skin penetration Skin permeation In vitro permeation and penetration experiments were performed using modified Franz diffusion cells and pig ear skin. Porcine skin was used as a surrogate for human skin as several studies have proved that permeation rates range from 50 to 150...
Skin Pharmacol Physiol (2012) 25 (6): 281–287.
Published Online: 07 August 2012
...- L -carnosine was carried out at wavelengths of 222 and 210 nm, respectively. Statistical significance was determined by 1-way ANOVA followed by Dunnett’s Test as post hoc analysis. Differences were considered as significant at p < 0.05. Skin penetration of L -carnosine and N...
Skin Pharmacol Physiol (2011) 25 (1): 9–16.
Published Online: 17 August 2011
... microdialysis Probe depth Skin penetration Topical drug administration Benzoic acid Ex vivo study Original Paper Skin Pharmacol Physiol 2012;25:9 16 DOI: 10.1159/000330491 Received: November 25, 2010 Accepted after revision: May 9, 2011 Published online: August 17, 2011 Probe Depth Matters in Dermal...
Skin Pharmacol Physiol (2011) 24 (5): 274–283.
Published Online: 24 June 2011
...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Skin penetration Cinnamaldehyde Penetration enhancers Local lymph node assay Ethanol Aqueous ethanol Propylene glycol...
M. Farwick, G. Gauglitz, T. Pavicic, T. Köhler, M. Wegmann, K. Schwach-Abdellaoui, B. Malle, V. Tarabin, G. Schmitz, H.C. Korting
Skin Pharmacol Physiol (2011) 24 (4): 210–217.
Published Online: 11 March 2011
... molecular size, skin penetration of HA may be limited. Recent studies have demonstrated that low-molecular-weight HA (LMW HA) may show a certain proinflammatory activity. We thus aimed to characterize an LMW-sized HA molecule that combines strong anti-aging abilities with efficient skin penetration...
Skin Pharmacol Physiol (2011) 24 (4): 199–209.
Published Online: 24 February 2011
...-particle interaction, drug release and skin penetration were investigated including a conventional oil-in-water cream for reference. Both with SLN and cream, PD release was clearly superior to PC release which exceeded BMV release. With the cream, the rank order did not change when studying skin...
Skin Pharmacol Physiol (2010) 23 (5): 225–243.
Published Online: 18 May 2010
... Microdialysis Skin penetration Skin barrier Bioavailability Bioequivalence Drug delivery, topical Abstract Microdialysis (MD) in the skin is a unique technique for in vivo sampling of topically as well as systemically administered drugs at the site of action, e.g. sampling the unbound tissue...
Skin Pharmacol Physiol (2009) 22 (6): 299–304.
Published Online: 25 September 2009
...S.E. dal Belo; L.R. Gaspar; P.M.B.G. Maia Campos; J.-P. Marty Green tea (Camellia sinensis) and Ginkgo biloba extracts in cosmetic formulations have been suggested to protect the skin against UV-induced damage and skin ageing. Thus, it is very important to assess the human skin penetration...