... disorders and has been associated with systemic health issues, but its specific impact on skin health remains unclear. This study aimed to investigate whether SF impairs skin barrier function and identify the biological pathways involved in SF-induced skin damage. Methods: Twenty-four 6-week-old male...

...Carine Jacques; Caroline Dejean; Christian Klose; Emilie Leccia; Sandrine Bessou-Touya; Alain Delarue; Hélène Duplan Introduction: The stratum corneum (SC) matrix is composed of free fatty acids, cholesterol, and ceramides (CERs), which play a key role in the skin barrier function. Changes...

... lipids (ICLs), folding properties of keratin, water mobility, and hydrogen bonding states. The results showed that the strongest skin barrier function, which is primarily manifested by the orthorhombic organization of ICLs, is provided at ≈20–40% SC depth, which is related to the maximal bonding state...

.... Differentiation Keratinocyte Proliferation Skin barrier function Sphingomyelin Sphingomyelin synthase National Institutes of Health (NIH) 10.13039/100000002 Sphingomyelin (SM), which is a phosphosphingolipid, is a ubiquitous constituent of cellular membranes. During activation...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Facial skin Malaysian women Biophysical parameters Skin barrier function Skincare functions Skin, being...

...Jin Song Ri; Se Hyok Choe; Johannes Schleusener; Jürgen Lademann; Chun Sik Choe; Maxim E. Darvin The skin barrier function is mostly provided by the stratum corneum (SC), the uppermost layer of the epidermis. To noninvasively analyze the physiological properties of the skin barrier functionin vivo...

.... Decreased stratum corneum thickness was observed after waxing. Diffusion cell studies showed increased skin permeation especially in case of dry shaving, electric epilation and waxing. Conclusion: Considering CRS and diffusion cell data, a moderate if significant decrease in skin barrier function was found...

... equal in all cases. Conclusions: This study demonstrated effective delivery of caffeine as a hydrophilic model drug into and through hair follicles and showed that follicles and surrounding regions may be targeted by optimised formulations for specific treatments. Skin and hair follicle Skin barrier...

..., instructions or products referred to in the content or advertisements. Skin barrier restoration Skin barrier function Moisturization Horse oil Microneedle Dermal therapy Clinical practice Horse oil (HO) has been used in cosmetic products in Eastern countries. Despite a lack of rigorous...

... and a significantly weaker skin barrier function compared to native human skin. Potential reasons for the latter might be the lack of mechanical forces during skin model cultivation which is performed classically in static well-plate setups. Mechanical forces and shear stress have a major impact on tissue formation...

... of supplementation of synthetic and animal-based CERs in replenishing the depleted natural skin CERs and restoring the skin barrier function have been investigated. Recently, however, the barrier function improving effect of plant-derived CERs has attracted much attention. Phyto-derived CERs (phytoCERs...

... Capacitance Skin barrier molecular composition Skin barrier function Table 2 Forearm measurements Table 3 Cheek measurements Table 4 Thenar measurements The average concentration profiles of water, NMF, and ceramides in the forearm and cheek for all groups are shown...

... of daily emollient use especially in infants having dry skin and being at risk to develop AD. Recently, a comparison of two different emollients revealed significant effects on skin barrier function [ 7 ]. Furthermore, clinical trials especially focusing on children already affected by AD recommend...

... of atopic patients with barrier-enhancing formulations to reduce the impact of pollen on air-exposed skin areas and hence the exacerbation of cutaneous symptoms. Atopic dermatitis (AD) is a common skin disease with impaired skin barrier function [ 1,2 ]. In previous studies it was found that pollen...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Percutaneous penetration Skin absorption Human skin  Freezing Storage conditions Skin barrier function Steady-state...

...Denise Falcone; Natallia E. Uzunbajakava; Babu Varghese; Gabriela Ricardo de Aquino Santos; Renée J.H. Richters; Peter C.M. van de Kerkhof; Piet E.J. van Erp Skin barrier function, confined to the stratum corneum, is traditionally evaluated using established, noninvasive biophysical methods like...

...-FTIR Tape stripping Anionic surfactants Natural surfactants Skin barrier function Skin hydration Micelles Surfactants, one of the main ingredients of personal care products and drug delivery systems, are well-known irritants and are recognized to diminish the properties of the stratum...

...R.H. Guy The 20- to 25-year period from the mid-1960s to the early 1990s represents, in many ways, a ‘golden era' in the understanding of skin barrier function, percutaneous penetration and (trans)dermal drug delivery. From the ground-breaking mechanistic work of Scheuplein and Blank, and the ‘gold...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Biophysical measuring methods Skin physiology Male skin Skin aging Skin barrier function The US Federal Food, Drug, and Cosmetic Act defines cosmetics...

...J.M. Jungersted; L.I. Hellgren; T. Drachmann; G.B.E. Jemec; T. Agner Background and Objective: Lipids in the stratum corneum (SC) are of major importance for the skin barrier function. Many different methods have been used for the collection of SC for the analysis of SC lipids. The objective...